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69 (4): TOXINA DIARREICA

(35) SATAKE M, MACKENZIE L, YASUMOTO T. (1997) Identification of Protoceratium
reticulatum as the biogenetic origen of yessotoxin. Nat Toxins 5: 164-167.

(36) TUBAZO A, SIDARI L, LOGIA LD, YASUMOTO T.(1998) Ocurrence of yessotoxin-
like toxins in phytoplankton and mussels from northern Adriatic Sea. En B
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IOC/UNESCO; 470-472.

(37) MURATA M, SHIMATANI M, SUGITANI H, OSHIMA Y, YASUMOTO T. (1982) Isola-
tion and structure elucidation of the causative toxin of the diarrhetic shellfish
poisoning. Bull Jpn Soc Sci Fish 43; 549-552.

(38) LEE JS, IGARASHI T, FRAGA S, DAHL E, BOGAD P, YASUMOTO T.(1989) Determi-
nation of diarrhetic shellfish toxins in various dinoflagellates species. J Appl
Phycol 1: 147-152.

(39) MURAKAMI Y, OSHIMA Y, YASUMOTO T. (1982) Identification of okadaic acid as
a toxic component of a marine dinoflagellate Prorocentrum lima. Bull Jpn Soc
Sci Fish 48: 69-72.

(40) TACHIBANA K, SCHEUER PJ; TSUKITANI Y, KIKUCHI H, VAN ENGEN D, CLARDY
J, GOPICHAND Y, SCHMITZ FJ.(1981) Okadaic acid, a cytotoxic polyether from
two marine sponges of the genus Halichondria, J Am Chem Soc 103: 2469-
2471.

(41) YASUMOTO T, MURATA M, OSHIMA Y, SANO M, MATSUMOTO GK, CLARDY
J.(1985) Diarrhetic shellfish toxins. Tetrahedron 41:1019-1025.

(42) HU T, DEFREITAS ASW, DOYLE J, JACKSON D, MARR J, NIXON E, PLEASANCE S,
QUILLIAM MA, WALTERJA, WRIGHT JLC.(1992) Isolation of a new diarrhetic
shellfish poison from Irish mussels. Chem Commun 30:39-41.

(43) MURATA M, SANO M, IWASHITA T, NAOKI H, YASUMOTO T. (1986) The structure
of pectenotoxin-3, a new constituent of diarrhetic shellfish toxins. Agric Biol
Chem 50:2693.

(44) MURATA M, KUMAGAI M, LEE JS, YASUMOTO T. (1987) Isolation a structure of
yessotoxin, a novel polyether compound implicated in diarrhetic shellfish poi-
soning. Tetrahedron Lett 28:5869-5872.

(45) BIALOJAN C, TAKAI A. (1988) Inhibitory effect of a marine-sponge toxin, oka-
daic acid, on protein phosphatases. Specificity and kinetics. Biochem J 256:
283-290.

(46) HAMANO Y, HINOSHITA Y, YASUMOTO T.(1986) Enteropathogenicity of diar-
rhetic shellfish toxins in intestinal models. J Food Hyg Soc Jpn 27: 375-379.

(47) TERAO K, ITO E, YANAGI T, YASUMOTO T. (1986) Histopathological studies on
experimental marine toxin poisoning. I. Ultraestructural changes in the small

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