Page 76 - 83_01
P. 76
Mitochondrial ROS and mtDNA fragments inside nuclear DNA as a main effector of ageing: the “cell aging regulation system”
94. Sanz A, Gomez J, Caro P, Barja G. Carbohydrate sites in the mitochondrial electron transport chain. J
restriction does not change mitochondrial free radical Biol Chem 2002; 277: 44784–90.
generation and oxidative DNA damage. J Bioenerg
Biomembr 2006; 38: 327-33. 106. Pamplona R, Portero-Otín M, Sanz A, Ayala V,
Vasileva E, Barja G. Protein and lipid oxidative
95. Sanz A, Caro P, Barja G. Protein restriction without damage and complex I content are lower in the brain
strong caloric restriction decreases mitochondrial of budgerigards and canaries than in mice. Relation to
oxygen radical production and oxidative DNA damage aging rate. AGE (Dordr) 2005; 27: 267–80.
in rat liver. J Bioenerg Biomembr 2004; 36: 545-52.
107. Spasojevic I, Bogdanovic Pristov J, Vujisic L, Spasic
96. Ayala V, Naudi A, Sanz A, Caro P, Portero-Otin M, M. The reaction of methionine with hydroxyl radical:
Barja G, et al. Dietary protein restriction decreases reactive intermediates and methanethiol production.
oxidative protein damage, peroxidizability index, and Amino Acids 2012; 42: 2439-45.
mitochondrial complex I content in rat liver. J
Gerontol A Biol Sci Med Sci 2007; 62: 352-60. 108. Taylor ER, Hurrell F, Shannon RJ, Lin TK, Hirst J,
Murphy MP. Reversible glutathionylation of complex
97. Sanz A, Caro P, Ayala V, Portero-Otin M, Pamplona I increases mitochondrial superoxide formation. J Biol
R, Barja G. Methionine restriction decreases Chem 2003; 278: 19603–10.
mitochondrial oxygen radical generation and leak as
well as oxidative damage to mitochondrial DNA and 109. Robert L, Labat-Robert J, Robert AM. Genetic,
proteins. FASEB J 2006; 20: 1064-73. epigenetic and posttranslational mechanisms of aging.
Biogerontology 2010; 11: 387–99.
98. Sanchez-Roman I, Gomez A, Gomez J, Suarez H,
Sanchez C, Naudi A, et al. Forty percent methionine 110. Passarino G, Rose G, Bellizzi D. Mitochondrial
restriction lowers DNA methylation, complex I ROS function, mitochondrial DNA and ageing: a
generation, and oxidative damage to mtDNA and reappraisal. Biogerontology 2010; 11: 575–88.
mitochondrial proteins in rat heart. J Bioenerg
Biomembr 2011; 43: 699-708. 111. Brosnan JT, Brosnan ME,. The sulfur-containing
amino acids: an overview. J Nutr 2006; 136: 1636S–
99. Sanchez-Roman I, Gómez A, Pérez I, Sanchez C, 40S.
Suarez H, Naudí A, et al. Effects of aging and
methionine restriction applied at old age on ROS 112. Christensen BC, Houseman EA, Marsit CJ, Zheng S,
generation and oxidative damage in rat liver Wrensch MR, Wiemels JL et al. Aging and
mitochondria. Biogerontology 2012; 13: 399-411. environmental exposures alter tissue-specific DNA
methylation dependent upon CpG island context.
100. Caro P, Gómez J, López-Torres M, Sánchez I, Naudí PLoS Genet 2009; Aug;5(8):e1000602.doi:
A, Jove M, et al. Forty percent and eighty percent 10.1371/journal.pgen.1000602. Epub.
methionine restriction decrease mitochondrial ROS
generation and oxidative stress in rat liver. 113. Wakeling LA, Ions LJ, Ford D. Could Sirt1-mediated
Biogerontology 2008; 9: 183–96. epigenetic effects contribute to the longevity response
to dietary restriction and be mimicked by other dietary
101. Naudi A, Caro P, Jove M, Gomez J, Boada J, Ayala interventions? Age (Dordr) 2009; 31: 327-41.
V, et al. Methionine restriction decreases endogenous
oxidative molecular damage and increases 114. Maegawa S, Hinkal G, Kim HS, Shen L, Zhang L,
mitochondrial biogenesis and uncoupling protein 4 in Zhang J, et al. Widespread and tissue specific age-
rat brain. Rejuvenation Res 2007; 10: 473-84. related DNA methylation changes in mice. Genome
Res 2010; 20; 332-40.
102. Caro P, Gomez J, Sanchez I, Naudí A, Ayala V,
Lopez-Torres M, et al. Forty percent methionine 115. Cedar H, Bergman Y. Programming of DNA
restriction decreases mitochondrial oxygen radical methylation patterns. Annu Rev Biochem 2012; 81:
production and leak at complex I during forward 97-117.
electron flow and lowers oxidative damage to proteins
and mitochondrial DNA in rat kidney and brain 116. Heyn H, Li N, Ferreira HJ, Moran S, Pisano DG,
mitochondria. Rejuvenation Res 2009; 12: 421–34. Gómez A, Diez J, et al. Distinct DNA methylomes of
newborns and centenarians. PNAS USA 2012; 109:
103. Yang Y, Ji Y, Wu G, Sun K, Dai Z, Wu Z. Dietary L- 10522-7.
methionine restriction decreases oxidative stress in
porcine liver mitochondria. Exper Gerontol 2015; 65: 117. Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P
35-41. et al. NAD repletion improves mitochondrial and stem
cell function and enhances life span in mice. 2016;
104. Caro P, Gomez J, Sanchez I, Garcia R, López-Torres 352: 1436-43.
M, Naudí A, et al. Effect of 40 % restriction of dietary
amino acids—except methionine— on mitochondrial 118. Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy
oxidative stress and biogenesis, AIF and SIRT1 in rat JO. Long-term effects of calorie or protein restriction
liver. Biogerontology 2009; 10: 579–92. on serum IGF-1 and IGFBP-3 concentration in
humans. Aging Cell 2008; 7: 681-7.
105. St-Pierre J, Buckingham JA, Roebuck SJ, Brand MD.
Topology of superoxide production from different 119. Miller RA, Harrison DE, Astle CM, Baur JA, Boyd
AR, de Cabo R, et al. Rapamycin, but not resveratrol
or simvastatin, extends life span of genetically
@Real Academia Nacional de Farmacia. Spain 77