Page 75 - 83_01
P. 75
108: 16831-6. Gustavo Barja de Quiroga
68. Kalhan SC, Uppal SO, Moorman JL, Bennett C, Gruca Physiol Rev 1970; 50: 428-558.
LL, Parimi PS, et al. Metabolic and genomic response
to dietary isocaloric protein restriction in the rat. J 81. Park CM, Cho CW, Rosenfeld ME, Song YS.
Biol Chem 2011; 286: 5266-77. Methionine supplementation accelerates oxidative
stress and nuclear factor kappaB activation in livers of
69. Malloy VL, Perrone CE, Mattocks DA, Ables GP, C57BL/6 mice. J Med Food 2008; 11: 667-74.
Caliendo NS, Orentreich DS. Methionine restriction
prevents the progression of hepatic steatosis in leptin- 82. Gomez J, Caro P, Sanchez I, Naudi A, Jove M,
deficient obese mice. Metabolism 2013; 62: 1651-61. Portero-Otín M, et. al. Effect of methionine dietary
supplementation on mitochondrial oxygen radical
70. Orgeron ML, Stone KP, Wanders D, Cortez CC, Vant generation and oxidative DNA damage in rat liver and
NT, Gettys TW. The impact of dietary methionine heart. J Bioenerg Biomembr 2009; 41: 309–21.
restriction on biomarkers of metabolic health. Prog
Mol Biol Transl Sci 2014; 121: 351-76. 83. Hidiroglou N, Gilani GS, Long L, Zhao X, Madere R,
Cockell K et al. The influence of dietary vitamin E,
71. Ramaligan A, Wang X, Gabello M, Valenzano MC, fat, and methionine on blood cholesterol profile,
Soler AP, Ko A, et al. Dietary methionine restriction homocysteine levels, and oxidizability of low density
improves colon tight junction barrier function and lipoprotein in the gerbil. J Nutr Biochem 2004; 15:
alters claudin expression pattern. Am J Physiol Cell 730-40.
Physiol 2010; 299: C1028-35.
84. Troen AM, Lutgens E, Smith DE, Rosenberg IH,
72. Hasek BE, Stewart LK, Henagan TM, Boudreau A, Selhub J. The atherogenic effect of excess methionine
Lenard NR, Black C, et al. Dietary methionine intake. PNAS USA 2003; 100: 15089-94.
restriction enhances metabolic flexibility and
increases uncoupled respiration in both fed and fasted 85. Kumagai H, Katoh S, Hirosawa K, Kimura M, Hishida
states. Am J Physiol Regul Integr Comp Physiol 2010; A, Ikegaya N. Renal tubulointerstitial injury in
299: R728–39. weanling rats with hyperhomocysteinemia. Kidney Int
2002; 62: 1219-28.
73. Komninou D, Leutzinger Y, Reddy BS, Richie JP Jr.
Methionine restriction inhibits colon carcinogenesis. 86. Mori N, Hirayama K. Long-term consumption of a
Nutr Cancer 2006; 54: 202-8. methionine-supplemented diet increases iron and lipid
peroxide levels in rat liver. J Nutr 2000; 130: 2349-55.
74. Cavuoto P, Fenech MF. A review of methionine
dependency and the role of methionine restriction in 87. Gomez J, Sanchez-Roman I, Gomez A, Sanchez C,
cancer growth control and life-span extension. Cancer Suarez H, Lopez-Torres M, et al. Methionine and
Treat Rev 2012; 38: 726-36. homocysteine modulate the rate of ROS generation of
isolated mitochondria in vitro. J Bioenerg Biomembr
75. Cao WX, Ou JM, Fei XF, Zhu ZG, Yin HR, Yan M, et 2011; 43: 377-86.
al. Methionine-dependence and combination
chemotherapy on human gastric cancer cells in vitro. 88. Ciorba MA, Heinemann SH, Weissbach H, Brot N,
World J Gastroenterol 2002; 8: 230-2. Hoshi T. Modulation of potassium channel function
by methionine oxidation and reduction. PNAS USA
76. Malloy VL, Krajcik RA, Bailey SJ, Hristopoulos G, 1997; 94: 9932–7.
Plummer JD, Orentreich N. Methionine restriction
decreases visceral fat mass and preserves insulin 89. Chung H, Kim AK, Jung SA, Kim SW, Yu K, Lee JH.
action in aging male Fischer 344 rats independent of The Drosophila homolog of methionine sulfoxide
energy restriction. Aging Cell 2006; 5: 305-14. reductase A extends lifespan and increases nuclear
localization of FOXO. FEBS Lett 2010; 584: 3609–
77. Perrone CE, Malloy VE, Orentreich DS, Orentreich N. 14.
Metabolic adaptations to methionine restriction that
benefit health and lifespan in rodents. Exp Gerontol 90. Moskovitz J, Bar-Noy S, Williams WM, Requena J,
2013; 48: 654-60. Berlett BS, Stadtman ER. Methionine sulfoxide
reductase (MsrA) is a regulator of antioxidant defense
78. Perrone CE, Mattocks DAL, Plummer JD, Chittur SV, and lifespan in mammals, PNAS USA 2001; 98:
Mohney R, Vignola K, et al. Genomic and metabolic 12920-5.
responses to methionine-restricted and methionine-
restricted, cysteine-supplemented diets in Fischer 344 91. Lim DH, Han JY, Kim JR, Lee YS, Kim HY.
rat inguinal adipose tissue, liver and quadriceps Methionine sulfoxide reductase B in the endoplasmic
muscle. J Nutrigenet Nutrigenom 2012; 5: 132-157. reticulum is critical for stress resistance and aging in
Drosophila. Biochem Biophys Res Commun 2012;
79. Elshorbagy AK, Valdivia-Garcia M, Mattocks DA, 419: 20-6.
Plummer JD, Smith AD, Drevon CA, et al. Cysteine
supplementation reverses methionine restriction 92. Uthus EO, Brown-Borg HM. Methionine flux to
effects on rat adiposity: significance of stearoyl- transsulfuration is enhanced in the long living Ames
coenzyme A desaturase. J Lipid Res 2011; 52: 104-12. dwarf mouse. Mech Ageing Dev 2006; 127: 444-50.
80. Harper AE, Benevenga NJ, Wohlhueter RM. Effects of 93. Sanz A, Caro P, Sanchez JG, Barja G. Effect of lipid
ingestion of disproportionate amounts of amino acids. restriction on mitochondrial free radical production
and oxidative DNA damage. Ann N Y Acad Sci 2006;
76 1067: 200-9.
@Real Academia Nacional de Farmacia. Spain
