Page 207 - 80_01
P. 207
ARTÍCULO
Novel
Compounds
containing
1,3,4--oxadiazole
and
pyrazole--3--
one
Nuclei
–
Synthesis
and
in
vitro
Antimicrobial
Evaluation
Krishna
Naik1,
Aluru
Raghavendra
Guru
Prasad2*,
Yadati
Narasimha
Spoorthy1,
Mokkapati
Pariplavi3,
Lakshmana
Rao
Krishna
Rao
Ravindranath1
1Sri
Krishnadevaraya
University,
Anantapur,
A.P.,
India.
2ICFAI
Foundation
for
Higher
Education,
Hyderabad,
A.P.,
India.3Osmania
Medical
College,
Osmania
University,
Hyderabad,
A.P.,
India.
*e--mail:
guruprasadar@yahoo.co.in
An.
Real
Acad.
Farm.
Vol
80,
Nº
1(2014),
pág.
201--213
ABSTRACT
New
series
of
heterocycles
containing
1,3,4--oxadiazole
and
pyrazole--3--one
moiety
have
been
synthesized
and
evaluated
in
vitro
against
Staphylococus
aureus
NCCS
2079,
Bacillus
cereus
NCCS
2106,
Escherichia
coli
NCCS
2065,
Pseudomanas
aeruginosa
NCCS
2200,
Aspergillus
niger
NCCS
1196
and
Candida
albicans
NCCS
2106.
The
compounds
demonstrated
moderate
antimicrobial
activity
against
selected
fungal
and
bacterial
strains.
Keywords:
Synthesis;
1,3,4--Oxadiazoles;
Pyrazole--3--ones;
Antimicrobial
activity.
RESUMEN
Nuevos
compuestos
que
contienen
núcleos
1,3,4--oxadiazol
y
pirazol--3--ona.
Sintesis
y
actividad
antimicrobiana
"in
vitro"
Nuevas
series
de
compuestos
heterocíclicos
que
contienen
1,3,4--oxadiazol
y
pyrazol--3--ona
han
sido
sintetizadas
y
evaluadas
in--vitro
contra
Staphylococus
aureus
NCCS
2079,
Bacillus
cereus
NCCS
2106,
Escherichia
coli
NCCS
2065,
Pseudomanas
aeruginosa
NCCS
2200,
Aspergillus
niger
NCCS
1196
y
Candida
albicans
NCCS
2106.
Los
compuestos
demostraron
actividad
antimicrobiana
moderada
contra
estirpes
fúngicas
y
bacterianas
seleccionadas.
Palabras
clave:
Síntesis;
1,3,4--Oxadiazol;
Pyrazol--3--uno;
Actividad
antimicrobiana.
201
