Page 127 - 78_02
P. 127
SESIÓN
CIENTÍFICA
PREMIO
NOBEL
2011….
35.
Fooksman
,D.R.;
Vardhana,
S.;
Vasiliver--Shamis,
G.;
Liese,
J.;
Blair,
D.A.;
Waite,
J.;
Sacristán,
C.;
Victora,
G.D.;
Zanin--Zhorov,
A.;
Dustin,
M.L.;
Functional
anatomy
of
T
cell
activation
and
synapse
formation.
Annu
Rev
Immunol.
2010,
28,
79--105.
36.
Montoya,
M.C.;
Sancho,
D.;
Vicente--Manzanares,
M.;
Sánchez--Madrid,
F.;
Cell
adhesion
and
polarity
during
immune
interactions.
Immunol.
Rev.
2002,
186,
68--82.
37.
Martín--Cófreces,
N.B.;
Robles--Valero,
J.;
Cabrero,
J.R.;
Mittelbrunn,
M.;
Gordón--Alonso,
M.;
Sung,
C.H.;
Alarcón,
B.;
Vázquez
,J.;
Sánchez--Madrid,
F.;
MTOC
translocation
modulates
IS
formation
and
controls
sustained
T
cell
signaling.
J
Cell
Biol.
2008,
182,
951--962.
38.
Sánchez--Madrid,
F.;
del
Pozo,
M.A.;
Leukocyte
polarization
in
cell
migration
and
immune
interactions.
EMBO
J.
1999,
18,
501--511.
39.
Billadeau,
D.D.;
Nolz,
J.C.;
Gomez,
T.S.;
Regulation
of
T--cell
activation
by
the
cytoskeleton.
Nat
Rev
Immunol.
2007,
7,
131--143.
40.
Vicente--Manzanares,
M.;
Sánchez--Madrid,
F.;
Role
of
the
cytoskeleton
during
leukocyte
responses.
Nature
Rev.
Immunol.
2004,
4,
110--122.
41.
de
la
Fuente,
H.;
Mittelbrunn,
M.;
Sánchez--Martín,
L.;
Vicente--Manzanares,
M.;
Lamana,
A.;
Pardi,
R.;
Cabañas,
C.;
Sánchez--Madrid,
F.;
Synaptic
clusters
of
MHC
class
II
molecules
induced
on
DCs
by
adhesion
molecule--mediated
initial
T--cell
scanning.
Mol
Biol
Cell.
2005,
16,
3314--3322.
42.
Mittelbrunn,
M.;
Martínez
del
Hoyo,
G.;
López--Bravo,
M.;
Martín--Cofreces,
N.B.;
Scholer,
A.;
Hugues,
S.;
Fetler,
L.;
Amigorena,
S.;
Ardavín,
C.;
Sánchez--Madrid,
F.;
Imaging
of
plasmacytoid
dendritic
cell
interactions
with
T
cells.
Blood.
2009,
113,
75--84.
43.
Zhu,
J.;
Paul,
W.E.;
CD4
T
cells:
fates,
functions,
and
faults.
Blood.
2008,
112,
1557--1569.
44.
O'Shea,
J.J.;
Paul,
W.E.;
Mechanisms
underlying
lineage
commitment
and
plasticity
of
helper
CD4+
T
cells.
Science.
2010,
327,
1098--1102.
45.
Huse,
M.;
Quann,
E.J.;
Davis,
M.M.;
Shouts,
whispers
and
the
kiss
of
death:
directional
secretion
in
T
cells.
Nat
Immunol.
2008,
9,
1105--11.
46.
Stinchcombe,
J.C.;
Griffiths,
G.M.;
Secretory
mechanisms
in
cell--mediated
cytotoxicity.
Annu
Rev
Cell
Dev
Biol.
2007,
23,
495--517.
47.
Mittelbrunn,
M.;
Gutierrez--Vazquez,
C.;
Villarroya--Beltri,
C.;
Gonzalez,
S.;
Sanchez--Cabo,
F.;
Gonzalez,
M.A.;
Bernad,
A.;
Sanchez--Madrid,
F.;
Unidirectional
transfer
of
microRNA--loaded
exosomes
from
T
cells
to
antigen--presenting
cells.
Nat
Commun.
2011,
2,
282.
48.
Riol--Blanco,
L.;
Delgado--Martin,
C.;
Sanchez--Sanchez,
N.;
Alonso,
C.L.;
Gutierrez--Lopez,
M.D.;
Del
Hoyo,
G.M.;
Navarro,
J.;
Sanchez--Madrid,
F.;
Cabanas,
C.;
Sanchez--Mateos,
P.;
Rodriguez--
Fernandez,
J.L.;
Immunological
synapse
formation
inhibits,
via
NF--kappaB
and
FOXO1,
the
apoptosis
of
dendritic
cells.
Nat
Immunol.
2009,
10,
753--760.
49.
Perez--Gracia,
J.L.;
Berraondo,
P.;
Martínez--Forero,
J.;
Alfaro,
C.;
Suarez,
N.;
Gurpide,
A.;
Sangro,
B.;
Hervas--Stubbs,
S.;
Ochoa,
C.;
Melero,
J.A.;
Melero,
I.
Clinical
development
of
combination
strategies
in
immunotherapy:
are
we
ready
for
more
than
one
investigational
product
in
an
early
clinical
trial?
Immunotherapy.
2009,
1,
845--853.
50.
Maldonado,
R.A.;
von
Andrian,
U.H.;
How
tolerogenic
dendritic
cells
induce
regulatory
T
cells.
Adv
Immunol.
2010,
108,
111--65.
51.
Manicassamy,
S.;
Pulendran,
B.;
Dendritic
cell
control
of
tolerogenic
responses.
Immunol
Rev.
2011,
241,
206--227.
263