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GUZMÁN-­-ARANGUREN
Y
COLS

Figure
1.
FGFR3
expression
after
siRNA
transfection.
siRNAs
were
introduced
into
human

achondroplastic
chondrocytes
and
FGFR3
mRNA
(A)
and
FGFR3
protein
(B)
were
assessed
72
h
later.
*P

<
0.05,
**P
<
0.01.

Figure
2.
Effect
of
FGFR3
knockdown
on
ERK1/2
phosphorylation.
Cell
lysates
of
human

achondroplastic
chondrocytes
transfected
with
siRNAs
were
successively
inmunoblotted
with
anti-­-
pERK1/2
and
anti-­-ERK2
antibody
to
verify
equal
loading.
*P
<
0.05.

8