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MARÍA ÁNGELES GARCÍA Y COLS. AN. R. ACAD. NAC. FARM.

Overall, our studies provided evidence for a new class of an on-
colytic VACV vector inducing low levels of PKR in tumour cells and
lacking TK, as a product to selectively destroy tumour cells, not by di-
rect killing but probably by the triggering of innate immune mecha-
nisms, like the inflammasome.

5. ACKNOWLEDGEMENTS

This investigation was supported, in part, by Foundation Marcelino
Botín and SAF2008-02036. We thank Victoria Jiménez for expert tech-
nical assistance and Alan Goodman for editing the manuscript.

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