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DAVID LEÓN NAVARRO Y COLS.  AN. R. ACAD. NAC. FARM.

receptors and that result in a prolonged inhibitory effect of [Ca2+]i
increase. In the mechanism involved for this control is participating
the CaMKII, although other kinases seem to be involved, at least
at short term. Additional work will be necessary to investigate the
possibility of glutamate/ATP receptors interaction in cortex and
hippocampus where release of both neurotransmitters can occur
simultaneously.

5. REFERENCES

 1. Bastian, A. J.; Mugnaini, E. & Thach, W. T. (1999) Cerebellum. In Fundamental
       Neuroscience, Ed. Zigmond, M. J.; Bloom, F. E.; Landis, S. C.; Roberts, J. L.
       & Squire, L. R. Academic Press, San Diego, California, USA. pp. 973-992.

 2. Garthwaite, J. & Brodbelt, A. R. (1990) Glutamate as the principal mossy fibre
       transmitter in rat cerebellum: pharmacological evidence. Eur. J. Neurosci. 2:
       177-180.

 3. Masgrau, R.; Servitja, J. M.; Young, K. W.; Pardo, R.; Sarri, E.; Nahorski, S.
       R. & Picatoste, F. (2001) Characterization of the metabotropic glutamate
       receptors mediating phospholipase C activation and calcium release in
       cerebellar granule cells: calcium-dependence of the phospholipase C response.
       Eur. J. Neurosci. 13: 248-256.

 4. Hervás, C.; Pérez-Sen, R. & Miras-Portugal, M. T. (2003) Coexpression of
       functional P2X and P2Y nucleotide receptors in single cerebellar granule cells.
       J. Neurosci. Res. 73: 384-399.

 5. Sánchez-Nogueiro, J.; Marín-García, P. & Miras-Portugal, M. T. (2005)
       Characterization of a functional P2X7-like receptor in cerebellar granule
       neurons from P2X7 knockout mice. FEBS Lett. 579: 3783-3788.

 6. León, D.; Hervás, C. & Miras-Portugal, M. T. (2006) P2Y1 and P2X7 receptors
       induce calcium/calmodulin-dependent protein kinase II phosphorylation in
       cerebellar granule neurons. Eur. J. Neurosci. 23: 2999-3013.

 7. León, D.; Sánchez-Nogueiro, J.; Marín-García, P. & Miras-Portugal, M. T.
       (2008) Glutamate release and synapsin-I phosphorylation induced by P2X7
       receptors activation in cerebellar granule neurons. Neurochem. Int. 52: 1148-
       1159.

 8. Sánchez-Nogueiro, J.; Marín-García, P.; León, D.; León-Otegui, M.; Salas, E.;
       Gómez-Villafuertes, R.; Gualix, J. & Miras-Portugal, M. T. (2009) Axodendritic
       fibres of mouse cerebellar granule neurons exhibit a diversity of functional
       P2X receptors. Neurochem. Int. 55: 671-682.

 9. Volonté, C.; Amadio, S.; D’Ambrosi, N.; Colpi, M. & Burnstock, G. (2006) P2
       receptor web: complexity and fine-tuning. Pharmacol. Therap. 112: 264-280.

10. Miras-Portugal, M. T.; Marín-García, P.; Carrasquero, L. M. G.; Delicado, E.
       G.; Díaz-Hernández, M.; Díaz-Hernández, J. I.; Díez-Zaera, M.; Fideu, M. D.;
       Gómez-Villafuertes, R.; Gualix, J.; León, D.; León-Otegui, M.; Ortega, F.; Pérez-

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