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VOL. 75 (2), 217-231, 2009 (CU)II IN VIVO INTERACTION WITH CEFOTAXIME

Figure 1. Mechanism of the hydrolytic reaction of Cefotaxime with addition of
Copper.

This communication stresses in how the formation of the complex
between Cu(II) and cefotaxime affects on the concentration,
distribution and stability of this cephalosporin. The importance of
the formation of this complex stems from the lowest concentration
of free cefotaxime in blood and organs only when takes place
intoxication. This free-antibiotic concentration could be lower than
the administration of the antibiotic required killing the micro-
organism that causes the infection.

We compared the concentration, distribution and stability of the
free cefotaxime in rats without toxic with poisoned rats, after 30, 60,
90, 120, 150, 180 and 210 min. after administrating this antibiotic.
This comparison was achieved by measuring the concentration of
free cefotaxime in blood, liver, spleen, kidney, lung and heart
homogenates of poisoned rats and rats without the toxic. The

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