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TERESA PELÁEZ Y COLS. ANAL. REAL ACAD. NAC. FARM.

Concerning the MT3 melatonin receptor, some authors have
indicated that after receptor stimulation the intracellular concen-

tration of IP3 and diacylglycerol in increased in hamster melanoma
cells and in Xenopus melanophores (13).

FIGURE 6. Schematic diagram showing the main melatonin receptors and the
second messengers system to which they are coupled.

ACKNOWLEDGEMENTS

This work has been supported by research grants from the
Ministerio de Educacion y Ciencia (SAF2004-06119-C2-01 and
SAF2007-60835), Fundación La Caixa (BM05-102-0) and Universidad
Complutense PR1/07-14890. PA-E holds a fellowship from Fundación
La Caixa. AM holds a fellowship from Universidad Complutense de
Madrid and PL holds fellowship from Art. 83 (CENIT proyect).

BIBLIOGRAFÍA

(1) PINTOR, J. AND PERAL, A. (2001) Therapeutic potential of nucleotides in the eye.
Drug Dev. Res. 52: 190-195.

(2) MOLINARI, E.J.; NORTH, P.C. AND DUBOCOVICH, M.L. (1996) 2-[125I]Iodo-5-me-
thoxycarbonylamino-N-acetyltryptamine: a selective radioligand for the cha-
racterization of melatonin ML2 binding sites. Eur. J. Pharmacol. 301: 159-
168.

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