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VOL. 73 (4), 947-962, 2007 MELATONIN MAKES ME FEEL AWAKE!...

FIGURE 5. Effect of the chemical denervation after treatment with 6-OH
dopamine. The application of this chemical destroys noradrenergic terminals and

this is reflected in a clear reduction in the effect of 5-MCA-NAT.

MELATONIN ON THE OCULAR SURFACE

Melatonin and its role in corneal wound healing

Corneal wound healing experiments we performed in New
Zealand white rabbits, demonstrated that after a superficial wound,
melatonin at low micromolar concentrations, significantly accelerate
the rate of healing closing the wounds faster than in the absence of
this neurohormone (9). This effect is antagonised by luzindole, this
is suggesting the presence of MT1 or MT2 melatonin receptors. We
jumped to a primary rabbit corneal epithelial cell culture in order to
perform more detailed biochemical studies. In the in vitro model the
same behaviour carried out by melatonin and luzindole was

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