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VOL. 73 (3), 703-746, 2007 ARE ADRENOMEDULLIN POSITIVE MODULATORS NOVEL...

TABLE 1. Summary of the most important Zinc Binding Groups (ZBGs) described
in the literature (11). Atoms implicated in zinc coordination are displayed in bold
format. ZBGs with unknown binding mode are displayed without bold atoms (cont.)

Name Representative Name Representative
Structure Structure

Thiadiazole Sulfodiimine
thione

Pyridone and Hydroxipiranone
Pyridinetione and

Hydroxipiranthinone

Pyrimidin- N-pyrimidin-amide
carbonil Hydroxysulfonamide

Aminomethyl Hydroxyurea
benzimidazole

Pirrol carbonyl

Dipicolylamine ß-Lactam

Squaric Acid
(X=O, S)

Several new ZBGs have been recently described (11). The
hydrazide scaffold has also been described as a good ZBG, and
exhibits potent selectivity for MMP-2 versus MMP-1. Brown et al.
described a novel ZBG based on a thiirane moiety, which behaves
similarly to TIMP-1 and TIMP-2, the natural tissue inhibitors of
MMPs (13). Barbiturates have also been cocrystalized (PDB code:
1g4k) in complex with MMP-3 but no information on the activity as

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