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MARIO A. GARCÍA Y COLS. AN. R. ACAD. NAC. FARM.

described ZBGs (Table 1 summarises the most important ZBGs
described in the literature), no MMPI has been licensed for treatment
of cancer until date. This is mainly due to low activity, low selectivity,
high toxicity, low bioavailability and/or low solubility. Only one
MMPI, PeriostatTM (CollaGenex Pharmaceuticals, Inc.), a low-dose
tetracycline derivative, is licensed for use in periodontitis and it is
under clinical trials for other indications (12). Thus, research focused
on the search of new ZBG becomes necessary.

TABLE 1. Summary of the most important Zinc Binding Groups (ZBGs) described
in the literature (11). Atoms implicated in zinc coordination are displayed in bold

format. ZBGs with unknown binding mode are displayed without bold atoms

Name Representative Name Representative
Structure Structure

Hydroxamate Reverse
Carboxylate Hydroxamate
Thiol carbonyl
Phosphate Thiol

Dithiol

Phosphinate

Carbamoyl Tetracycline
Phosphonate Thiirane

Hydrazide Thiadiazine

Barbiturate

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