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VOL. 72 (4), 563-581, 2006 ABERRANT MRNA STABILITY REGULATION IN HUMAN...

TABLE 1. List of AU-rich binding proteins (AUBPs) (cont.)

RNA- Official name Gene Symbol & Subcellular Function Target mRNAs
binding (Ref Seq) localization (examples)
protein

Nuclear (20%) mRNA PAI-2 (1),
and
TTP Tristetraprolin TTP cytoplasmic destabilizing TNF-a (1),
TIA-1 (NM_003407) (80%)
Mainly nuclear (1), decapping COX-2 (1),
TIAR
KSRP Mainly nuclear (2) GM-CSF (2)
BRF1
cytotoxic Mostly nuclear Translational
granule-
associated RNA TIA1 represor (1), COX-2 (1),
binding protein (NM_022173)
alternative TNF-a (1),

RNA Fos (2)

processing (2)

TIA1 cytotoxic TIAL1 Translational IL-8 (1), iNOS

granule- (NM_003252) represor (1), (1), ß2-AR (1),

associated RNA alternative GADD45 (1),

binding KHSRP RNA calcitonin/

protein-like 1 (NM_003685) processing (2) CGRP (2)

mRNA

KH-type destabilizing c-fos (1), c-jun
splicing
regulatory (1), RNA (1), IL-2 (1),
protein
splicing (2) TNF-a (1), iNOS

(2)

zinc finger ZFP36L1 Nuclear and mRNA cIAP2, IL-3
protein 36, (NM_004926) cytoplasmic
C3H type- destabilizing
like 1

interleukin ILF3 Mainly nuclear mRNA IL-2 (1), acid
enhancer (3 isoforms: stabilization beta-
NF90 binding factor NM_004516; (1), glucosidase (2)
3, 90kDa NM_012218; Translational
NM_153464) represor (2)

CUG- CUG triplet CUGBP2 Mainly nuclear RNA editing Apolipoprotein
BP2 repeat, RNA (3 isoforms: (1), mRNA B (1), COX-2
binding M_001025076; stabilization (2 and 3)
protein 2 NM_001025077; (2) and
NM_006561) translational
silencer (3)

Numbers in brackets of each individual target mRNAs refer to the matched function shown for each
specific RNA-binding protein.

DEFECTIVE mRNA STABILITY REGULATION IN HUMAN
DISEASES

Several human diseases, outlined below, are associated to
mutations in 3’UTR mRNA stability determinants or to alterations in
the regulation of 3’UTR-binding regulatory proteins. Next, specifics
examples will be given to illustrate both aspects.

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