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VOL. 72 (4), 611-627, 2006 HEME RESPONSIVENESS IN VITRO IS A COMMON...
(12) SANTOYO, J.; ALCALDE, J.; MÉNDEZ, R.; PULIDO, D. and DE HARO, C. (1997): Cloning
and characterization of a cDNA encoding a protein synthesis initiation factor-
(13) 2a (eIF-2a) kinase from Drosophila melanogaster. Homology to yeast GCN2
protein kinase. J. Biol. Chem. 272: 12544-12550.
(14) POMAR, N.; BERLANGA, J. J.; CAMPUZANO, S.; HERNÁNDEZ, G.; ELÍAS, M. and DE
(15) HARO, C. (2003): Functional characterization of Drosophila melanogaster
(16) PERK eukaryotic initiation factor 2a (eIF2a) kinase. Eur. J. Biochem. 270:
(17) 293-306.
(18) HARDING, H. P.; NOVOA, I.; ZHANG, Y.; ZENG, H.; WEK, R.; SHAPIRA, M. and RON,
D. (2000): Regulated translation initiation controls stress-induced gene
(19) expression in mammalian cells. Mol. Cell 6: 1099-1108.
(20) HANKS, S. K. and HUNTER, T. (1995): The eukaryotic protein kinase
superfamily: kinase (catalytic) domain structure and classification. FASEB J.
(21) 9: 576-596.
(22) CAI, R. and WILLIAMS, B. R. (1998): Mutations in the double-stranded RNA-
(23) activated protein kinase insert region that uncouple catalysis from eIF2alpha
(24) binding. J. Biol. Chem. 273: 11274-11280.
CHEFALO, P. J.; OH, J.; RAFIE-KOLPIN, M.; KAN, B. and CHEN, J. J. (1998): Heme-
regulated eIF2alpha kinase purifies as a hemoprotein. Eur. J. Biochem. 258:
820-830.
RAFIE-KOLPIN, M.; CHEFALO, P. J.; HUSSAIN, Z.; HAHN, J.; UMA, S.; MATTS, R. L.
and CHEN, J. J. (2000): Two heme-binding domains of heme-regulated
eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion.
J. Biol. Chem. 275: 5171-5178.
ZHANG, L. and GUARENTE, L. (1995): Heme binds to a short sequence that
serves a regulatory function in diverse proteins. EMBO J. 14: 313-320.
BERLANGA, J. J.; VENTOSO, I.; HARDING, H. P.; DENG, J.; RON, D.; SONENBERG, N.;
CARRASCO, L. and DE HARO, C. (2006): Antiviral effect of the mammalian
translation initiation factor 2a kinase GCN2 against RNA viruses. EMBO J.
25: 1730-1740.
BERRA, E.; DÍAZ-MECO, M. T.; LOZANO, J.; FRUTOS, S.; MUNICIO, M. M.; SÁNCHEZ,
P.; SANZ, L. and MOSCAT, J. (1995): Evidence for a role of MEK and MAPK
during signal transduction by protein kinase C ?. EMBO J. 14: 6157-6163.
MÉNDEZ, R. and DE HARO, C. (1994): Casein kinase II is implicated in the
regulation of heme-controlled translation inhibitor of reticulocyte lysates. J.
Biol. Chem. 269: 6170-6176.
LAEMMLI, U. K. (1970): Cleavege of structural proteins during the assembly of
the head of bacteriophage T4. Nature. 227: 680-685.
PONKA, P. (1999): Cell biology of heme. Am. J. Med. Sci. 318: 241-256.
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