Page 84 - 72_04
P. 84
SATURNINO HERRERO Y COLS. AN. R. ACAD. NAC. FARM.
for excellent technical assistance. This work was supported by
DGICYT Grants PM98-0128 and BMC2002-03933 and by an
institutional grant from the Fundación Ramón Areces to the Centro
de Biología Molecular «Severo Ochoa».
REFERENCES
(1) DE HARO, C.; MÉNDEZ, R. and SANTOYO, J. (1996): The eIF-2a kinases and the
(2) control of protein synthesis. FASEB J. 10: 1378-1387.
(3) DEVER, T. E. (2002): Gene-specific regulation by general translation factors.
(4) Cell. 108: 545-556.
LU, L.; HAN, A. P. and CHEN, J. J. (2001): Translation initiation control by
(5) heme-regulated eukaryotic initiation factor 2a kinase in erythroid cells under
(6) cytoplasmic stresses. Mol. Cell. Biol. 21: 7971-7980.
KAUFMAN, R. J. (2000): The double-stranded RNA-activated protein kinase
(7) PKR. in: Translational Control of Gene Expression (Sonenberg, N.; Hershey,
(8) J. W. B., and Mathews, M. B., Eds), pp. 503-527, Cold Spring Harbor
Laboratory Press, Cold Spring Harbor, NY.
(9) BERLANGA, J. J.; SANTOYO, J. and DE HARO, C. (1999): Characterization of a
(10) mammalian homolog of the GCN2 eukaryotic initiation factor 2akinase. Eur.
J. Biochem. 265: 754-762.
(11) HINNEBUSCH, A. G. (2000): Mechanism and regulation of initiator methionyl-
tRNA binding to ribosome. in: Translational Control of Gene Expression
(Sonenberg, N.; Hershey, J. W. B., and Mathews, M. B., Eds), pp. 185-243,
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
DENG, J.; HARDING, H. P.; RAUGHT, B.; GINGRAS, A. C.; BERLANGA, J. J.; SCHEUNER,
D.; KAUFMAN, R. J.; RON, D. and SONENBERG, N. (2002): Activation of GCN2 in
UV-irradiated cells inhibits translation. Curr. Biol. 12: 1279-1286.
SHI, Y.; VATTEM, K. M.; SOOD, R.; AN, J.; LIANG, J.; STRAMM, L. and WEK, R. C.
(1998): Identification and characterization of pancreatic eukaryotic initiation
factor 2a-subunit kinase, PEK, involved in translational control. Mol. Cell.
Biol. 18: 7499-7509.
HARDING, H. P.; ZHANG, Y. and RON, D. (1999): Protein translation and folding
are coupled by an endoplasmic-reticulum-resident kinase. Nature. 397: 271-
274.
ZHAN, K.; VATTEM, K. M; BAUER, B. N.; DEVER, T. E.; CHEN, J. J. and WEK, R.
C. (2002): Phosphorylation of eukaryotic initiation factor 2 by heme-regulated
inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is
important for resistance to environmental stresses. Mol. Cell. Biol. 22: 7134-
7146.
BERLANGA, J. J.; HERRERO, S. and DE HARO, C. (1998): Characterization of
the hemin-sensitive eukaryotic initiation factor 2a kinase from mouse
nonerythroid cells. J. Biol. Chem. 273: 32340-32346.
626