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FLORA DE PABLO Y COLS. AN. R. ACAD. NAC. FARM.
FIGURE 1. A) Mosaic representing a chick embryo of approximately 3 days of deve-
lopment (E3) (Photography courtesy of Prof. Nicole Le Douarin. Institut d’Embriologie
Cellulaire et Moléculaire, Nogent-sur-Marne, France). B) and D) In situ hybridization
to demonstrate proinsulin mRNA distribution in the E1.5 and E2.5 chick embryo
respectively. The image is processed in pseudocolor, red indicates high signal. C) and
E) In situ hybridization for IGF-I mRNA at the indicated days of development (25).
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