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LENNART K. PAALZOW AN. R. ACAD. NAC. FARM.
FIGURE 8. Patient treated with standard dose of phenytoin against epilepsy
(250 mgx2). Because of saturation of the metabolism, this drug dosing will lead
to toxic levels if continued.
A Bayesian estimate showed that this patient instead should have
a dose of 150 mg. two times daily in order to keep the concentration
within the therapeutic concentrations (Fig. 9).
FIGURE 9. The patient in Fig. 8 given the individually calculated dosing of
150 mgx2 yields a plasma concentration-time profile within the therapeutic
window.
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