Page 82 - 76_03
P. 82

ALBERTO BARTOLOMÉ Y COLS.  AN. R. ACAD. NAC. FARM.

21. Shigeyama, Y., Kobayashi, T., Kido, Y., Hashimoto, N., Asahara, S., Matsuda,
        T., Takeda, A., Inoue, T., Shibutani, Y., Koyanagi, M., Uchida, T., Inoue, M.,
        Hino, O., Kasuga, M. & Noda, T. (2008) Biphasic response of pancreatic beta-
        cell mass to ablation of tuberous sclerosis complex 2 in mice. Mol. Cell. Biol.
        28(9): 2971-2979.

22. Hamada, S., Hara, K., Hamada, T., Yasuda, H., Moriyama, H., Nakayama, R.,
        Nagata, M. & Yokono, K. (2009) Upregulation of the mammalian target of ra-
        pamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic
        beta-cells leads to increased beta-cell mass and prevention of hyperglycemia.
        Diabetes. 58(6): 1321-1332.

23. Seino, S. & Bell, G. I. (1989) Alternative splicing of human insulin receptor mes-
        senger RNA. Biochem. Biophys. Res. Commun. 159(1): 312-316.

24. McClain, D. A. (1991) Different ligand affinities of the two human insulin re-
        ceptor splice variants are reflected in parallel changes in sensitivity for insulin
        action. Mol. Endocrinol. 5(5): 734-739.

25. Denley, A., Wallace, J. C., Cosgrove, L. J. & Forbes, B. E. (2003) The insulin re-
        ceptor isoform exon 11- (IR-A) in cancer and other diseases: a review. Horm.
        Metab. Res. 35(11-12): 778-785.

26. Escribano, O., Guillén, C., Nevado, C., Gómez-Hernández, A., Kahn, C. R. &
        Benito, M. (2009) ß Cell hyperplasia induced by hepatic insulin resistance: role
        of a liver-pancreas endocrine axis through insulin receptor A isoform. Diabetes.
        58(4): 820-828.

27. Nevado, C., Benito, M. & Valverde, A. M. (2008) Role of insulin receptor and
        balance in insulin receptor isoforms A and B in regulation of apoptosis in simi-
        an virus 40-immortalized neonatal hepatocytes. Mol. Biol. Cell. 19(3): 1185-
        1198.

28. Ma, L., Teruya-Feldstein, J., Bonner, P., Bernardi, R., Franz, D. N., Witte, D.,
        Cordon-Cardo, C. & Pandolfi, P. P. (2007) Identification of S664 TSC2 phospho-
        rylation as a marker for extracellular signal-regulated kinase mediated mTOR ac-
        tivation in tuberous sclerosis and human cancer. Cancer Res. 67(15): 7106-7112.

29. Towler, M. C. & Hardie, D. G. (2007) AMP-activated protein kinase in metabol-
        ic control and insulin signaling. Circ. Res. 100(3): 328-341.

30. Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A.,
        Vasquez, D. S., Turk, B. E. & Shaw, R. J. (2008) AMPK phosphorylation of rap-
        tor mediates a metabolic checkpoint. Molecular Cell. 30(2): 214-226.

31. Ogata, M., Hino, S.-i., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S.,
        Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., Shiosaka, S., Hammarback,
        J. A., Urano, F. & Imaizumi, K. (2006) Autophagy is activated for cell survival
        after endoplasmic reticulum stress. Mol. Cell. Biol. 26(24): 9220-9231.

32. Desai, N. M., Goss, J. A., Deng, S., Wolf, B. A., Markmann, E., Palanjian, M.,
        Shock, A. P., Feliciano, S., Brunicardi, F. C., Barker, C. F., Naji, A. & Markmann,
        J. F. (2003) Elevated portal vein drug levels of sirolimus and tacrolimus in islet
        transplant recipients: local immunosuppression or islet toxicity? Transplantation.
        76(11): 1623-1625.

33. Leibiger, B., Leibiger, I. B., Moede, T., Kemper, S., Kulkarni, R. N., Kahn, C. R.,
        de Vargas, L. M. & Berggren, P. O. (2001) Selective insulin signaling through A

376
   77   78   79   80   81   82   83   84   85   86   87