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YANNICK GOUMON Y COLS. AN. R. ACAD. NAC. FARM.

mediator playing a role in physiological processes. Investigation
on endogenous morphine will continue to be an important axis of
research and efforts will be focus on the characterization of its
implication in physiology.

4. ACKNOWLEDGEMENT

This work was funded by Inserm, CNRS, the University Louis-
Pasteur at Strasbourg, the Fondation de France (to Y.G), the French
Ministère délégué à la Recherche et à l’Enseignement Supérieur
(Ph.D fellowship to A.M. and A.L.), the Fondation Transplantation
(to Y.G.) and the Fondation pour la Recherche Médicale (to Y.G.).

5. BIBLIOGRAPHY

1. Stefano, G. B., Goumon, Y., Casares, F., Cadet, P., Fricchione, G. L., Rialas,
C., et al. (2000) Endogenous morphine. Trends Neurosci. 23(9): 436-442.

2. Lotsch, J. (2005) Pharmacokinetic-pharmacodynamic modeling of opioids. J.
Pain Symptom. Manage. 29(5 Suppl): S90-103.

3. Lotsch, J. & Geisslinger, G. (2001) Morphine-6-glucuronide: an analgesic of
the future? Clin. Pharmacokinet. 40(7): 485-499.

4. Pert, C. B., Pasternak, G. & Snyder, S. H. (1973) Opiate agonists and
antagonists discriminated by receptor binding in brain. Science. 182(119):
1359-1361.

5. Trescot, A. M., Datta, S., Lee, M. & Hansen, H. (2008) Opioid pharmacology.
Pain Physician. 11(2 Suppl): S133-153.

6. Zadina, J. E., Hackler, L., Ge, L. J. & Kastin, A. J. (1997) A potent and
selective endogenous agonist for the mu-opiate receptor. Nature. 386(6624):
499-502.

7. Zhang, Y., Chen, Q. & Yu, L. C. (2008) Morphine: a protective or destructive
role in neurons? Neuroscientist. 14(6): 561-570.

8. Ding, Y. Q., Kaneko, T., Nomura, S. & Mizuno, N. (1996) Immunohisto-
chemical localization of mu-opioid receptors in the central nervous system
of the rat. J. Comp. Neurol. 367(3): 375-402.

9. Mansour, A., Fox, C. A., Burke, S., Akil, H. & Watson, S. J. (1995)
Immunohistochemical localization of the cloned mu opioid receptor in the
rat CNS. J. Chem. Neuroanat. 8(4): 283-305.

10. Bianchi, C., Sellke, F. W., Del Vecchio, R. L., Tonks, N. K. & Neel, B. G.
(1999) Receptor-type protein-tyrosine phosphatase mu is expressed in specific
vascular endothelial beds in vivo. Exp. Cell Res. 248(1): 329-338.

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