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J. A. RIBEIRO AN. R. ACAD. NAC. FARM.
of neurodegenerative diseases, A2A receptor antagonists can be
advantageous, in the early stages, where an enhancement of
neurotrophic factors should be highly desirable, A2A receptor
antagonists should be avoided in order to allow neurotrophic
influences.
Perspectives to explore the potential use of adenosine
to induce neuroprotection
By using A2A agonists or adenosine kinase inhibitors (which
induce the production of considerable amounts of endogenous
adenosine) that cross blood brain barrier, it would be possible to
promote the facilitation of BDNF or GDNF actions on synaptic
transmission (see Figure 2).
FIGURE 2. Perspectives to explore the potential use of adenosine to induce
neuroprotection. By using A2A agonists or adenosine kinase inhibitors
(which induce the production of considerable amounts of endogenous adenosine)
that cross blood brain barrier, it would be possible to promote the facilitation
of BDNF on synaptic transmission.
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