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be considered to analyse in depth their physiological function, the
possible diseases asociated to their disfuction and the pharma-
cological perspectives for their specific agonists and antagonists.

ACKNOWLEDGEMENTS

This work was supported by research grants from the Spanish
Ministry of Education and Science BFU2005-02079, the Fundación
La Caixa nº BM05-114-0, the Fundación Marcelino Botín and from
the Comunidad Autónoma de Madrid (SAL/0551/2004).

REFERENCES

(1) BURNSTOCK, G. (2006) Pathophysiology and therapeutic potencial of puriner-
(2) gic signaling. Pharmacol. Rev. 58, 58-86.
(3) BURNSTOCK, G. (2007) Physiology and pathophysiology of purinergic neuro-
(4) transmission. Physiol. Rev. 87, 659-797.
(5) BURNSTOCK, G. (2005) Purinergic signalling: therapeutic potential. An. R.
(6) Acad. Nac. Farm. 2: 283-319.
BURNSTOCK, G. (2006) Historical review: ATP as a neurotransmitter. Trends
(7) Pharmacol. Sci. 27: 166-176.
BURNSTOCK, G. (1972) Purinergic nerves. Pharmacol. Rev. 24: 509-581.
(8) RODRÍGUEZ DEL CASTILLO, A.; TORRES, M.; DELICADO, E.G. AND MIRAS-PORTUGAL,
M.T. (1988) Subcellular distribution studies of diadenosine polyphosphates
(9) -Ap4A and Ap5A- in bovine adrenal medulla: presence in chromaffin granu-
les. J. Neurochem. 51: 1696-1703.
(10) GUALIX, J.; ABAL, M.; PINTOR, J.; GARCÍA-CARMONA, F. AND MIRAS-PORTUGAL, M.T.
(11) (1996) Nucleotide vesicular transporter of bovine chromaffin granules. Evi-
dence for a mnemonic regulation. J. Biol. Chem. 271: 1957-65.
GUALIX, J.; FIDEU, M.D.; PINTOR, J.; ROTLLÁN, P.; GARCÍA-CARMONA, F. AND MIRAS-
PORTUGAL, M.T. (1997) Characterization of diadenosine polyphosphate trans-
port into chromaffin granules frm adrenal medulla. FASEB J. 11: 981-990.
BAHIMA, L.; ALEU, J.; ELIAS, M.; MARTÍN-SATUÉ, M.; MUHAISEN, A.; BLASI, J.;
MARSAL, J. AND SOLSONA, C. (2006) Endogenous hemichannels play a role in
the release of ATP from Xenopus laevis. J. Cell. Physiol. 206: 95-102.
ZIMMERMANN, H. (2000) Extracellular metabolism of ATP and other nucleoti-
des. Naunyn-Schmiedebergs Arch. Pharmacol. 362: 299-309.
ABBRACCHIO, M.P.; BURNSTOCK, G.; BOEYNAEMS, J.M.; BARNARD, E.A.; BOYER, J.L.;
KENNEDY, C.; MIRAS-PORTUGAL, M.T.; KING, B.F.; GACHET, C.; JACOBSON, K.A. AND
WEISMAN, G.A. (2005) The recently deorphanized GPR80 (GPR99) proposed
to be the P2Y15 receptor is not a genuine P2Y receptor. Trends Pharmacol.
Sci. 26: 8-9.

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