Page 174 - 73_04
P. 174

DOLORES PRIETO Y ALBINO GARCÍA SACRISTÁN  ANAL. REAL ACAD. NAC. FARM.

(61)  ANGULO, J.; CUEVAS, P.; MONCADA, I.; MARTIN-MORALES, A.; ALLONA, A.; FERNANDEZ,
      A.; GABANCHO, S.; NEY, P. AND SAENZ DE TEJADA, I. (2000): Rationale for the
(62)  combination of PGE(1) and S-nitroso-glutathione to induce relaxation of
(63)  human penile smooth muscle. J. Pharmacol. Exp. Ther. 295: 586-593.
(64)  BUSSE, R. AND FLEMING, I. (2003) Regulation of endothelium-derived vasoacti-
      ve autacoid production by hemodynamic forces. Trends Pharmacol. Sci. 24:
(65)  24-29.
      MUSICKI, B. AND BURNETT, A.L. (2006) eNOS Function and Dysfunction in the
(66)  penis. Exp. Biol. Med. 231: 154-165.
(67)  ANGULO. J.; CUEVAS, P.; FERNANDEZ, A.; GABANCHO, S.; VIDELA, S. AND SAENZ DE
      TEJADA, I. (2003) Calcium dobesilate potentiates endothelium-derived hyper-
(68)  polarizing factor-mediated relaxation of human penile resistance arteries. Br.
(69)  J. Pharmacol. 139: 854-862.
(70)  ANGULO, J.; CUEVAS, P.; FERNANDEZ, A.; GABANCHO, S.; ALLONA, A.; MARTIN-MORA-
(71)  LES, A.; MONCADA, I.; VIDELA, S. AND SAENZ DE TEJADA, I. (2003) Diabetes impairs
      endothelium-dependent relaxation of human penile vascular tissues media-
(72)  ted by NO and EDHF. Biochem. Biophys. Res. Commun. 312: 1202-1208.
(73)  VIRAG, R.; FLORESCO, J. AND RICHARD, G. (2004) Impairment of shear-stress-
(74)  mediated vasodilation of cavernous arteries in erectile dysfunction. Int. J.
(75)  Impot. Res. 16: 39-42.
      HURT, K.J.; MUSICKI, B.; PALESE, M.A.; CRONE, J.K.; BECKER, R.E.; MORIARITY,
      J.L.; SNYDER, S.H. AND BURNETT, A.L. (2002) Akt-dependent phosphorylation of
      endothelial nitric-oxide synthase mediates penile erection. Proc. Natl. Acad.
      Sci. USA. 99: 4061-4066.
      DIMMELER, S.; FLEMING, I.; FISSLTHALER, B.; HERMANN, C.; BUSSE. R. AND ZEIHER,
      A.M. (1999) Activation of nitric oxide synthase in endothelial cells by Akt-
      dependent phosphorylation. Nature. 399: 601-605.
      BIVALACQUA, T.J.; USTA, M.F.; CHAMPION, H.C.; KADOWITZ, P.J. AND HELLSTROM,
      W.J. (2003) Endothelial dysfunction in erectile dysfunction: role of the endo-
      thelium in erectile physiology and disease. J. Androl. 24: S17-S37.
      BUSSE, R.; EDWARDS, G.; FELETOU, M.; FLEMING, I., VANHOUTTE, P.M. AND WESTON,
      A.H. (2002) EDHF: bringing the concepts together. Trends Pharmacol. Sci 23:
      374-380.
      KUN, A.; MARTINEZ, A.C.; TANKO, L.B.; PATARICZA, J.; PAPP, J.G. AND SIMONSEN, U.
      (2003) Ca2+-activated K+ channels in the endothelial cell layer involved in
      modulation of neurogenic contractions in rat penile arteries. Eur. J. Pharma-
      col. 474: 103-115.
      HEDLUND, P.; ASZODI, A.; PFEIFER, A.; ALM, P.; HOFMANN, F.; AHMAD, M.; FASSLER,
      R. AND ANDERSSON, K.E. (2000) Erectile dysfunction in cyclic GMP-dependent
      kinase I-deficient mice. Proc. Natl. Acad. Sci. USA 97: 2349-2354.
      SCHLOSSMANN, J.; FIEL, R. AND HOFMANN, F. (2003) Signalling through NO and
      cGMP-dependent protein kinases. Ann. Med. 35: 21-27.
      CHRIST, G.J. (2002) K+ channels as molecular targets for the treatment of
      erectile dysfunction. J. Androl. 23: S10-S9.
      PRIETO. D.; RIVERA, L.; BENEDITO, S.; RECIO, P.; VILLALBA, N.; HERNANDEZ, M. AND
      GARCIA-SACRISTAN, A. (2006) Ca2+-activated K+ (KCa) channels are involved in

984
   169   170   171   172   173   174   175   176   177   178   179