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An. R. Acad. Nac. Farm., 2007, 73 (4): 947-962
Revisión
Melatonin Makes Me Feel Awake!
Seven Years of Lab Experience (2000-2007)
Recibido el 18 de octubre de 2007
TERESA PELÁEZ, ARÁNZAZU MEDIERO, PILAR ALARMA-
ESTRANY, PATRICIA LOMA, ANA I. GUZMÁN-ARÁNGUEZ,
ALMUDENA CROOKE, BASILIO KOLLIGRIS, ASSUMPTA PERAL
AND JESÚS PINTOR*
Departamento de Bioquímica, E. U. Óptica. Universidad
Complutense de Madrid.
ABSTRACT
The research on the effect of melatonin on intraocular pressure (IOP) is
reviewed from the hystorical point of view of our laboratory. The original idea of
melatonin modulating intraocular pressure has been improved by using selective
compounds for MT2 and specially melatonin MT3 receptors. The selective
compound 5-methoxyamino N-acetyltryptamine (5-MCA-NAT) has been an
attractive compound due to its ability to reduce IOP about 40%, therefore being a
good candidate to the treatment of the ocular hypertension linked to glaucoma.
More compounds have been developed and tested permitting us to have a more
accurate panorama of those receptors controlling the relevant process of
intraocular pressure.
Key words: Melatonin, melatonin receptors, intraocular pressure, MT3 receptor.
RESUMEN
¡La melatonina me hace sentir despierto! Siete años de experiencia en
el laboratorio (2000 – 2007)
La investigación sobre el efecto de la melatonina sobre la presión intraocular
(PIO) es revisada desde la perspectiva histórica de nuestro laboratorio. La idea
* Dirección de contacto:
Dr. Jesús Pintor.
Dep. Bioquímica. E.U. Óptica. Universidad Complutense de Madrid. C/ Arcos de
Jalón, s/n. 28037. Madrid. Tel.: +34-91-3946859. Fax.: +34-91-3946885.
e-mail: jpintor@vet.ucm.es
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