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VOL. 73 (3), 763-784, 2007 FROM PATHOGENESIS TO THERAPEUTIC OF TYPE 2...

FIGURE 6. GLP-1 restores blunted glucose-stimulated insulin secretion by GK
islets. Wistar or GK islets were perifused with a medium containing 2.8 mM

Glucose (G). G16.7 and GLP-1 were added as indicated. A and B: [Ca2+]i values.
C and D: insulin secretion. Data are means of 4 to 8 experiments from three to

six different islet preparations in each group.

of the abstract and past and present members of the laboratory for
their continuing efforts.

REFERENCES

(1) DONATH, M. Y. and HALBAN P. A. (2004): Decreased beta-cell mass in diabetes:
significance, mechanisms and therapeutic implications. Diabetologia. 47: 581-
589.

(2) DEL GUERRA, S.; LUPI, R.; MARSELLI, L.; MASINI, M.; BUGLIANI, M.; SBRANA, S.;
TORRI, S.; POLLERA, M.; BOGGI, U.; MOSCA, F.; DEL PRATO, S. and MARCHETTI, P.
(2005): Functional and molecular defects of pancreatic islets in human type
2 diabetes. Diabetes. 54: 727-735.

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