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VOL. 73 (1), 5-26, 2007 IN VITRO INVESTIGATION OF DRUG METABOLISM AND TOXICITY...
c) Prediction of in vivo pharmacokinetic parameters from in
vitro data.
d) Identification of the P450 enzymes involved in drug
metabolism.
e) Interspecies comparison of the metabolic profile of a drug to
select the animal. species closest to man for preclinical
studies.
f) Drug-drug interactions due to enzyme induction/inhibition.
g) Drug toxicity associated with drug metabolism.
FIGURE 2. Major applications of in vitro hepatic models during the
development of new drugs.
DRUG METABOLIC STABILITY AND METABOLIC PROFILE
AND METABOLITE IDENTIFICATION
Using in vitro methods enables us to determine and predict the
metabolic stability of NCEs, which can be an important contributor
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