Page 101 - 72_03
P. 101

VOL. 72 (3), 519-538, 2006  NEW PERSPECTIVES IN OCULAR PHARMACOLOGY...

dry eye condition. Other such as denufosol, aka dCp4U, is on clinical
trials. This dinucleotide is useful for the treatment of the retinal
detachment since it reabsorbs the liquid that is accumulated between
photoreceptors and the retinal pigmented epithelium. Following the
same philosophy it will not be strange to see in the near future
pharmaceutical compounds based on dinucleotides suitable for the
treatment of ocular pathologies such as glaucoma, corneal wound
healing or ocular surface infections.

                                    REFERENCES

(1) RALEVIC, V. and BURNSTOCK, G. (1998): Receptors for purines and pyrimidines.
       Pharmacol. Rev. 50: 413-492.

(2) BURNSTOCK, G. (2005): Purinergic signalling: therapeutic potencial. Anal. Real
       Acad. Nac. Farm. 71: 283-319.

(3) HOLLOPETER, G.; JANTZEN, H. M.; VINCENT, D.; LI, G.; ENGLAND, L.; RAMAKRISHNAN,
       V.; YANG, R. B.; NURDEN, P.; JULIUS, D. and CONLEY, P. B. (2001): Identification
       of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409:
       202-207.

(4) MARÍN-GARCÍA, P.; GÓMEZ-VILLAFUERTES, R. and GUALIX, J. (2005): Los receptores
       de nucleótidos P2Y reducen la entrada de calcio inducida por despolarización
       en terminales sinápticos de cerebro medio de rata. Anal. Real Acad. Nac.
       Farm. 71: 659-672.

(5) HERVÁS, C.; LEÓN, D.; SEN, R. P. and MIRAS-PORTUGAL, M. T. (2005): Activación
       de la calcio calmodulina quinasa II, CaMKII, por el uridin nucleósido
       difosfato, UDP, en neuronas granulares de cerebelo. Anal. Real Acad. Nac.
       Farm. 71: 439-449.

(6) WEISMAN, G. A.; GONZÁLEZ, F. A.; ERB, L.; GARRAD, R. C. and TURNER, J. T.
       (1998): The cloning and expression of G-coupled P2Y nucleotide receptors.
       In: Turner JT, Weisman GA, Fedan JS, editors. The P2 nucleotide receptors.
       Totowa, NJ: Humana Press. p. 63-79.

(7) COMMUNI, D.; GONZÁLEZ, N. S.; DETHREUX, M.; BREZILLION, S.; LANNOY, V.;
       PARMENTIER, M. and BOEYNAEMS, J. M. (2001): Identification of a novel human
       ADP receptor coupled to Gi. J. Biol. Chem. 276: 41479-41485.

(8) ZHANG, F. L.; LUO, L.; GUSTAFSON, E.; PALMER, K.; QIAO, X.; FAN, X.; YANG, S.;
       LAZ, T. M.; BAYNE, M. and MONSMA, F. (2002): P2Y13: identification and
       characterisation of a novel Gai-coupled ADP receptor from human and
       mouse. J. Pharmacol. Exp. Ther. 301: 705-713.

(9) CHAMBERS, J. K.; MACDONALD, L. E., SARAU, H. M., AMES, R. S.; FREEMAN, K.;
       FOLEY, J. J., ZHU, Y.; MCLAUGHILIN, M. M.; MURDOCK-MCMILLAN, L.; TRILL, J.;
       SWIFT, A.; AIYAR, N.; TAYLOR, P.; VAWTER, L.; NAHEED, S.; SZEKERES, P.; HERVIEU,
       G.; SCOTT, C.; WATSON, J. M.; MURPHY, A. J.; DUZIC, E.; KLEIN, C.; BERGSMA-

                                                                                            535
   96   97   98   99   100   101   102   103   104   105   106