Page 100 - 72_03

JESÚS PINTOR AN. R. ACAD. NAC. FARM.

FIGURE 4. P2Y receptors present in trabecular meshwork cells. A. P2Y
receptors produce the shrink of trabecular meshwork cells this permitting the

facilitation of the aqueous humour drainage. B. Visualization of a single
trabecular meshwork cell in culture after being challenged with Ap4A. It can be

noticed how the cell shrinks after the superfusion of the dinucleotide.

CONCLUDING REMARKS

The function of mono and dinucleotides in the eye indicates that
these group of substances are developing interesting roles in three
important ocular processes: tear production, wound healing and
intraocular pressure. They are present in tears and in the aqueous
humour, therefore indicating they are naturally activating and/or
modulating these physiological processes. In addition, the topical
administration of some of these compounds can rescue the eye from
some pathological situations.

We are not so far away from finding any of these compounds
in the pharmacy. Diquafosol, also termed Up4U, has passed FDA
requirements to soon appear in the USA market as a treatment for

534