Page 131 - 69_04

VOL. 69 (4) Adenosine A1 receptor Adenosine A2A r
Ri ; AA1R A2a, Rs; AA2AR
Previous/Alternative
names CPA, CCPA, CHA CGS 21680, HE
Selective agonists 1808, CV-1674, A
Selective antagonists DPCPXa 8-cyclopentyl-
selective: SCH
Radioligands theophylline, WRC0571 moderately
ZM241385a, KF 1

[3H]-DPCPX; [3H]-CHA [3H]-CGS 21680
58261; [3H]-ZM-

Antibodies Several commercial and non- Several commerc
commercial peptide antibodies commercial

antibodies;

Structural information Human 326 aa, P30542, , rat 326 Human 410 aa,

(Accession numbers) aa, P25099, 409 aa, P30543,

aa, UO5672

G protein coupling Gi, Go Gs, Golf

Expression pattern in High expression: High expression:

nervous system. Brain (cortex, cerebellum, Striatopallidal

hippocampus). Dorsal horn of neurons (in caud

spinal cord. Eye, adrenal gland nucleus

Intermediate levels: tuberculum
Other brain regions. olfactory bulb

Low levels:Rest o

Gene name/chromosomal chr 1q32.1 chr 22g11.2
location

Main physiological Bradycardia; inhibition of Regulation of
integration in b
function(s) lipolysis; reduced glomerular inhibition of
aggregation
filtration; tubero-glomerular

feedback, antinociception;