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VOL. 74 (4) SIGNALS EMANATING FROM LEUKOCYTE...

PECAM-1 can trigger “outside-in” signals via PKC and PI-3K leading to
activation of alphav-beta3 (85).

CONCLUDING REMARKS

Understanding the complex signaling networks that govern the
extravasation process is of critical importance for the identification of
novel therapeutical targets in the treatment of chronic inflammatory and
autoimmune diseases. Moreover, the development of new non-invasive
and localized drug release strategies instead of systemic pharmacological
administration will contribute to this aim.

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