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An. R. Acad. Nac. Farm., 2008, 74 (4):

________Revisión_________

Signals emanating from leukocyte-endothelium
interactions during inflammation

Recibido el 28 de mayo de 2008

OLGA BARREIRO1,2 AND FRANCISCO SÁNCHEZ-MADRID1,2*

1Servicio de Inmunología, Hospital de la Princesa, Universidad
Autónoma de Madrid. Madrid, Spain.

2Departamento de Biología Vascular e Inflamación, Centro Nacional de
Investigaciones Cardiovasculares. Madrid, Spain.

ABSTRACT

Leukocyte trafficking throughout the vasculature is a crucial step for the
development of innate and adaptive immunity (1). The coordinate function of adhesion
receptors, cytoskeleton and signaling molecules in both cellular types is fundamental
during leukocyte extravasation. Hence, the correct integration of “outside-in” and
“inside-out” signals in leukocytes and endothelium during each stage of the process is
critical to allow the completion of the so-called “multi-step paradigm” (leukocyte
tethering and rolling involving selectins and their ligands, followed by leukocyte firm
adhesion and crawling mediated by integrins and their endothelial counter-receptors and
the subsequent diapedesis also mediated by junctional proteins) (2, 3). This review
focuses on the signaling pathways triggered during the extravasation that allow
leukocytes to efficiently migrate towards the inflammatory foci to exert their effector
functions.

* Correspondencia:
Dr. Francisco Sánchez-Madrid.
Servicio de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid.
C/ Diego de León 62, 28006. Madrid, Spain.
E-mail: fsanchez.hlpr@salud.madrid.org
Phone: 34-91-3092115
Fax: 34-91-5202374