Page 97 - 66_04

VOL 66 (4) 2000 IN VITRO INDUCTION OF APOPTOSIS BY CYCLOSPORINE A

(53) TANG D. G., LI L., ZHU Z., JOSHI B. (1998). Apoptosis in the absence of
cytochrome c, accumulation in the cytosol. Biochem. Biophys. Res. Commun.
242, 380-384.

(54) THOMAS S. E., ANDOH T. F., PICHLER R. H., SHANKLAND S. J., COUSER W.
G., BENNETT W. M., JOHNSON R. J. (1998). Accelerated apoptosis
characterizes cyclosporine-associated intestinal fibrosis. Kidney Internat. 53,
897-908.

(55) THORNBERRY N.A., LAZEBNIK Y. (1998). Caspases: Enemies within. Science
281, 1312-1316.

(56) TRENDELENBURG C. F. (1995). Oxidativer Stress als Mechanismus der
Cyclosporin A-Toxizität in Rattenhepatozyten Primärkulturen. Dissertation
D386, Fachbereich Chemie, Universität Kaiserslautern.

(57) VERMES I., HAANEN C., STEFFENS-NAKKEN H., REUTELINGSPERGER C.
(1995). A novel assay for apoptosis flow cytometric detection of
phosphatidylserine expression on early apoptotic cells using fluorescein-
labelled Annexin V. J. of Immunol. Meth. 184, 39-51.

(58) WEDLER A. A., ACOSTA D. (1994). Membrane integrity and function. In:
Methods in Toxicology (C. A. Tyson, J. M. Frazier, Eds.) Volume 1. Part B.
pp. 46–49. Academic Press, San Diego.

(59) WITKAMP (1995). Efficacy and tolerability of multi-dose SDZ IMM 125 in
patients with severe psoriasis. Brit. J. Dermatol. 133, 95-103.

(60) WOLF A., BROADHURST M. (1992). Cyclosporin A (Sandimmun®) induces
the formation of free reactive oxygen species in vitro in rat liver and kidney
microsomes. In: Oxygen Radicals. (K. Yagi, M. Kondo, E. Niki, T.
Yoshikawa, Ed.), pp. 525-528. Elsevier Science Publishers BV, Amsterdam.

(61) WOLF A., DONATSCH P. (1990). Cyclosporin A-dependent induction of lipid
peroxidation in rat liver and kidney, Free Radic. Biol. Med. 9, 123.

(62) WOLF A., SCHRAMM U., FAHR A., AICHER L., CORDIER A., TROMMER W. E.,
FRICKER G. (1998). Hepatocellular effects of cyclosporine A and its
derivative SDZ IMM 125 in vitro. J. Pharmacol. Exp. Ther. 284, 817-825.

(63) WOLF A., TRENDELENBURG C.-F., DIEZ-FERNANDEZ C., PRIETO P., CORDIER
A. (1994) Role of glutathione in cyclosporine A in vitro hepatotoxicity.
Transplant. Proceed. 26, 2912-2914.

(64) WOLF A., TRENDELENBURG C.-F., DIEZ-FERNANDEZ C., PRIETO P., HOUY S.,
TROMMER W. E., CORDIER A. (1997). Cyclosporine A-induced oxidative
stress in rat hepatocytes. J. Pharmacol. Exp. Ther. 280, 1328-1334.

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