Anales RANF

Abbracchio M.	233
CPL-01	16
S16-01EFFECTS OF ATP-INDUCED MICROGLIAL EXTRACELLULAR VESICLES ON OLIGODENDROCYTE PROGENITORS IN CEREBRAL ISCHEMIA	99
S16-04ACTIVATED MICROGLIA REGULATE THE RESPONSE OF OLIGODENDROCYTE PROGENITORS EXPRESSING THE P2Y-LIKE RECEPTOR GPR17 FOLLOWING CEREBRAL ISCHEMIA	102
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
Acker A.	233
P.64THE ADP RECEPTOR P2Y13 IS SELECTIVELY EXPRESSED IN BRAIN MICROGLIA AND CONSTITUTIVELY ATTENUATES HIPPOCAMPAL NEUROGENESIS	190
Adinolfi E.	233
Simposium 10: PURINERGIC RECEPTORS AND CANCER	68
S10-02P2X7 RECEPTOR IS A KEY REGULATOR OF ATP CONTENT AND IMMUNE INFILTRATION IN THE TUMOR MICROENVIRONMENT	70
P.15P2X7 RECEPTOR MODULATES THE OSTEOGENIC DIFFERENTIATION OF STROMAL STEM CELLS FROM HUMAN ADIPOSE TISSUE	141
P.60MITOCHONDRIA ARE A KEY TARGET OF AMYLOID β-DEPENDENT DAMAGE IN MOUSE MICROGLIAL CELLS: ROLE OF THE P2X7 RECEPTOR AND PROTECTION BY NIMODIPINE.	186
P.73P2X7 RECEPTOR INFLUENCES METASTATIC POTENTIAL AND VESICULAR RELEASE IN MELANOMA	199
Agostinho P.	233
S3-03ATP-DERIVED ADENOSINE CONTROLS SYNAPTIC AND MEMORY DYSFUNCTION IN β-AMYLOID MODELS OF ALZHEIMER’S DISEASE	37
Aguinaga D.	2
S9-04ADENOSINE A2A RECEPTOR ACTIVATION ATTENUATE NMDA RECEPTOR FUNCTION IN ALZHEIMER DISEASE	67
P.58ADENOSINE A2A RECEPTOR ANTAGONISTS POTENTIATE CANNABINOID SIGNALING IN MICROGLIA	184
Ahmadi P.	2
P7. PURINERGIC SIGNALING IN THE TUMORGROWTH ANDMETASTASISP.68CHARACTIZATION OF CD39 EXPRESSION ON T CELLS IN ACUTE MYELOID LEUKEMIA	194
Alameer A.	2
P.04STRUCTURAL MODELS FOR DICTOSTELIUM DISCOIDEUM P2X RECEPTORS	130
Albasanz J.	2
S2-03ADENOSINE RECEPTORS AS A PRIMARY TARGET FOR RESVERATROL: FROM ANTITUMORAL TO NEUROPROTECTION ACTION	31
P.69RESVERATROL ACTS THROUGH ADENOSINE RECEPTORS IN TUMORAL CELL LINES	195
Alçada S.	2
S15-02CORTICAL NEURONAL MIGRATION ENTAILS A2A RECEPTOR-DRIVEN NEURONAL POLARIZATION AND AXON FORMATION	95
Alcides L.	2
S1-01OVEREXPRESSION OF P2X3 AND P2X7 RECEPTORS AND TRPV1 CHANNELS IN ADRENOMEDULLARY CHROMAFFIN CELLS IN A RAT MODEL OF NEUROPATHIC PAIN	24
Alekseeva T.	2
P.20P.A METABOLIC IMMUNE CHECKPOINT: ADENOSINE IN BRAIN METASTASES TUMOR MICROENVIRONMENT	146
Alessio S.	2
P.80INVESTIGATION ON THE ROLE OF THE P2X7R-NLRP3-IL-1β AXIS IN THE PATHOGENESIS OF HIDRADENITIS SUPPURATIVA	206
P.85THE P2X7 RECEPTOR IS SHED INTO CIRCULATION AND CORRELATES WITH C-REACTIVE PROTEIN LEVELS	211
Allain A.	2
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Allegrini S.	2
S12-03IMPACT OF IMP-GMP SPECIFIC 5'-NUCLEOTIDASE ON METABOLIC REGULATION AND DRUG RESISTANCE IN TUMORS	81
Almeida L.	2
P.30NICOTINIC α7 RECEPTOR-INDUCED ADENOSINE RELEASE FROM PERISYNAPTIC SCHWANN CELLS CONTROLS ACETYLCHOLINE SPILLOVER FROM THE RAT MOTOR ENDPLATE	156
Alter C.	2
P9. PURINERGIC SIGNALING IN THE CARDIOVASCULAR SYSTEMP.86REGULATION OF IL-6 FORMATION IN THE HEART BY CD73-DERIVED ADENOSINE	212
P.90PURINE METABOLISM IN CARDIAC FIBROBLASTS AND EPICARDIUM-DERIVED CELLS, SIMULTANEOUSLY ISOLATED FROM THE INFARCTED MOUSE HEART	216
P.91IMPACT OF CD73-DERIVED ADENOSINE ON THE CELL-TYPE SPECIFIC CYTOKINE RESPONSE IN THE INFARCTED MURINE HEART	217
Álvarez A.	2
S2-05DRUG-INDUCED CARDIOVASCULAR TOXICITY MEDIATED BY P2X7 RECEPTORS: THE EXAMPLE OF ABACAVIR	33
Alves do Prado W.	2
P.30NICOTINIC α7 RECEPTOR-INDUCED ADENOSINE RELEASE FROM PERISYNAPTIC SCHWANN CELLS CONTROLS ACETYLCHOLINE SPILLOVER FROM THE RAT MOTOR ENDPLATE	156
Alves M.	2
P.35THE CONTRIBUTION OF THE P2X7R TO DRUG REFRACTORY STATUS EPILEPTICUS	161
CONTEXT-SPECIFIC SWITCH FROM ANTI- TO PRO-EPILEPTOGENIC FUNCTION OF THE P2Y1 RECEPTOR IN EXPERIMENTAL EPILEPSY	166
P.67BLOOD PURINE CONCENTRATION AS A NOVEL DIAGNOSTIC FOR SEIZURES AND EPILEPSY	193
Amadio S.	2
S20-04TARGETING P2X7 IN AMYOTROPHIC LATERAL SCLEROSIS: WHERE AND WHEN?	123
Ambiel C.	2
P.30NICOTINIC α7 RECEPTOR-INDUCED ADENOSINE RELEASE FROM PERISYNAPTIC SCHWANN CELLS CONTROLS ACETYLCHOLINE SPILLOVER FROM THE RAT MOTOR ENDPLATE	156
Ambrósio A.	2
P.76ADENOSINE A2A RECEPTOR MODULATION OF MICROGLIA MORPHOLOGIC REMODELLING IN EARLY NEURODEVELOPMENT - GENDER BIAS IN PHYSIOLOGY AND PSYCHIATRIC DISORDERS	202
Amico A.	2
P.80INVESTIGATION ON THE ROLE OF THE P2X7R-NLRP3-IL-1β AXIS IN THE PATHOGENESIS OF HIDRADENITIS SUPPURATIVA	206
Andrade G.	2
P.102SIGNIFICANCE OF ADENOSINE A2A RECEPTORS IN THE COMMENSAL-PATHOGEN SWITCH IN THE ELDERLY GUT	228
Andres B.	2
S15-02CORTICAL NEURONAL MIGRATION ENTAILS A2A RECEPTOR-DRIVEN NEURONAL POLARIZATION AND AXON FORMATION	95
Andrés R.	2
P.78ADENOSINE A2B RECEPTOR ACTIVATION IMPROVES EPIDERMAL BARRIER INTEGRITY DAMPENED BY INFLAMMATION	204
P.82THERAPEUTIC POTENTIAL OF ADENOSINE IN INFLAMMATORY SKIN DISEASES	208
Antonioli L.	2
Simposium 20: FIGHTING THE FIRE: NOVEL PURINERGIC APPROACHES TO MANAGE IMMUNE-MEDIATED DISORDERS	119
P8. PURINERGIC SIGNALING IN IMMUNOLOGY AND INFLAMMATIONP.74THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF AR170, A POTENT AND SELECTIVE A3 RECEPTOR AGONIST, IN A RAT MODEL OF COLITIS	200
P.97ADENOSINE A2B RECEPTORS ON ENTERIC GLIA MEDIATE COLONIC DYSMOTILITY ASSOCIATED WITH HIGH FAT DIET-INDUCED OBESITY	223
Apolloni S.	2
S20-04TARGETING P2X7 IN AMYOTROPHIC LATERAL SCLEROSIS: WHERE AND WHEN?	123
Arad U.	2
S18-01A QUEST FOR A DISEASE MODIFYING DRUG FOR THE TREATMENT OF OSTEOARTHRITIS-RELATED CALCIUM PYROPHOSPHATE DEPOSITION DISEASE	110
P.07DEVELOPMENT OF NPP1 INHIBITORS AS POTENTIAL DRUGS FOR THE TREATMENT OF OSTEOARTHRITIS/CPPD DISEASE	133
Aragón C.	2
S5-01MODULATION OF NEURONAL GLYCINE TRANSPORT BY P2Y AND P2X RECEPTORS	45
Arasa J.	2
P.78ADENOSINE A2B RECEPTOR ACTIVATION IMPROVES EPIDERMAL BARRIER INTEGRITY DAMPENED BY INFLAMMATION	204
P.82THERAPEUTIC POTENTIAL OF ADENOSINE IN INFLAMMATORY SKIN DISEASES	208
Areias F.	2
P2. PHARMACOLOGY AND BIOCHEMISTRY OF P1 RECEPTORSP.092-ARYLADENINE DERIVATIVES AS POTENT SCAFFOLDS FOR A1, A3 AND DUAL A1/A3 ADENOSINE RECEPTOR ANTAGONISTS: SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS	135
Arguin G	2
S18-01A QUEST FOR A DISEASE MODIFYING DRUG FOR THE TREATMENT OF OSTEOARTHRITIS-RELATED CALCIUM PYROPHOSPHATE DEPOSITION DISEASE	110
Arribas M.	2
S1-01OVEREXPRESSION OF P2X3 AND P2X7 RECEPTORS AND TRPV1 CHANNELS IN ADRENOMEDULLARY CHROMAFFIN CELLS IN A RAT MODEL OF NEUROPATHIC PAIN	24
Artalejo A.R.	2
Simposium 1: NOVEL INSIGHTS INTO P2X3 AND A3 RECEPTOR CONTRIBUTION TO PAIN STATES	23
S1-01OVEREXPRESSION OF P2X3 AND P2X7 RECEPTORS AND TRPV1 CHANNELS IN ADRENOMEDULLARY CHROMAFFIN CELLS IN A RAT MODEL OF NEUROPATHIC PAIN	24
Ascierto P.	2
P.21ANALYSIS OF CD73 IN SERUM OF CANCER PATIENTS AND HEALTHY DONORS	147
Ase A.R.	2
S8-03IDENTIFICATION OF A NON-COMPETITIVE ANTAGONIST SITE IN P2X RECEPTOR CHANNELS	61
Audinat E.	2
S16-02ASTROCYTE PURINERGIC SIGNALING ENHANCES EXCITATORY SYNAPTIC TRANSMISSION DURING EPILEPTOGENESIS	100
Azuaje J.	2
P.11A2B ANTAGONIST AS ANTIMETASTATIC AGENTS: DESIGN, SYNTHESIS AND OPTIMIZATION OF NOVEL CHEMOTYPES	137
Baalmann F.	2
P.98RENAL PAPILLA EXPRESSES HIGH LEVELS OF THE UDP-GLUCOSE RECEPTOR P2RY14	224
Bai C.	2
S17-04PURINERGIC SIGNALLING AND ACUPUNCTURE-INDUCED ANALGESIA	108
Balasubramanian R.	2
P.24URIDINE- AND CYTIDINE-BASED ECTO-5ꞌ-NUCLEOTIDASE-INHIBITORS: A NOVEL CLASS OF HIGHLY ACTIVE AND SELECTIVE CD73-INHIBITORS	150
Baptista F.	2
P.76ADENOSINE A2A RECEPTOR MODULATION OF MICROGLIA MORPHOLOGIC REMODELLING IN EARLY NEURODEVELOPMENT - GENDER BIAS IN PHYSIOLOGY AND PSYCHIATRIC DISORDERS	202
Baqi Y.	2
P.39ADENOSINE-MEDIATED CONTROL OF SYNAPTIC AND BEHAVIOURAL ACTIONS OF CANNABINOIDS	165
P.52SYNAPTIC DYSFUNCTIONS AT THE HIPPOCAMPUS OF AN AMYOTROPHIC LATERAL SCLEROSIS MOUSE MODEL (SOD1G93A): REVERSAL BY ADENOSINE A2AR BLOCKADE	178
Barahona M.	2
S1-01OVEREXPRESSION OF P2X3 AND P2X7 RECEPTORS AND TRPV1 CHANNELS IN ADRENOMEDULLARY CHROMAFFIN CELLS IN A RAT MODEL OF NEUROPATHIC PAIN	24
Barreda M.	2
P.45ARE micro-RNAs THERAPEUTIC TARGETS FOR SPINAL CORD INJURY EXCITOTOXICITY? microRNA-135a-5p REDUCES P2X7-DEPENDENT RISE IN INTRACELLULAR CALCIUM AND PROTECTS AGAINST EXCITOTOXICITY.	171
Barrera N	2
P.06ALFAXOLONE-INDUCED P2X4R ALLOSTERIC AGONISM CONFIRMED BY MOLECULAR DYNAMIC CALCULATIONS	132
Barth K.	233
P.105P2X7R INDIRECTLY REGULATES THE JAM-A PROTEIN CONTENT VIA MODULATION OF THE GSK-3β AND PKC-β1	231
Bartolomé D.	2
S5-01MODULATION OF NEURONAL GLYCINE TRANSPORT BY P2Y AND P2X RECEPTORS	45
Basílio J.	2
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING	213
Beamer E.	2
P.35THE CONTRIBUTION OF THE P2X7R TO DRUG REFRACTORY STATUS EPILEPTICUS	161
P.50A POSSIBLE IMPLICATION OF THE ATP-GATED P2X7 RECEPTOR ON STATUS EPILEPTICUS-INDUCED ABERRANT NEUROGENESIS	176
P.67BLOOD PURINE CONCENTRATION AS A NOVEL DIAGNOSTIC FOR SEIZURES AND EPILEPSY	193
Bégard S.	2
P.63NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES MEMORY DEFICITS IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE.	189
Beggiato S.	2
S9-03ADENOSINE HETERORECEPTOR COMPLEXES IN THE BASAL GANGLIA ARE IMPLICATED IN PARKINSON DISEASE AND ITS TREATMENT	66
Behrenswerth A	2
P.12DEVELOPMENT OF A LIVE CELL NANOBRET BINDING ASSAY FOR ADENOSINE A2B RECEPTORS	138
Bemelmans A.	2
P.63NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES MEMORY DEFICITS IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE.	189
Bendas G.	2
P.22INVESTIGATION OF HEPARIN-INDUCED ECTONUCLEOTIDASE-INHIBITION TO COUNTERACT ADENOSINE-MEDIATED IMMUNOSUPPRESSION IN THE TUMOR MICROENVIRONMENT	148
Benito M.	2
S10-04REGULATION OF P2X7 RECEPTOR GENE EXPRESSION IN NEUROBLASTOMA CELLS	72
P.71INHIBITION OF DUAL-SPECIFICITY PHOSPHATASES PROMOTES P2X7 RECEPTOR EXPRESSION IN NEUROBLASTOMA CELLS IN A p38-DEPENDENT MANNER	197
Benvenuti L.	2
P8. PURINERGIC SIGNALING IN IMMUNOLOGY AND INFLAMMATIONP.74THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF AR170, A POTENT AND SELECTIVE A3 RECEPTOR AGONIST, IN A RAT MODEL OF COLITIS	200
P.97ADENOSINE A2B RECEPTORS ON ENTERIC GLIA MEDIATE COLONIC DYSMOTILITY ASSOCIATED WITH HIGH FAT DIET-INDUCED OBESITY	223
Berchan M.	2
P.85THE P2X7 RECEPTOR IS SHED INTO CIRCULATION AND CORRELATES WITH C-REACTIVE PROTEIN LEVELS	211
Bergmann P.	2
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Bertin E.	2
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Bertrand S.	2
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Bessa C.	2
P10. PURINERGIC SIGNALING IN RENAL, GASTROINTESTINAL AND MUSCULOSKELETAL SYSTEMP.92ADP-INDUCED P2Y1-MEDIATED OSTEOGENESIS IS DOWNREGULATED BY OVEREXPRESSED P2Y12 AND P2Y13 RECEPTORS IN POSTMENOPAUSAL MESENCHYMAL STEM CELLS	218
Bettoli V.	2
P.80INVESTIGATION ON THE ROLE OF THE P2X7R-NLRP3-IL-1β AXIS IN THE PATHOGENESIS OF HIDRADENITIS SUPPURATIVA	206
Bezard E.	2
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Bhattacharya A.	2
P1. STRUCTURE OF PURINE RECEPTORS AND ECTONUCLEOTIDASESP.01IDENTIFICATION OF P2X7 RECEPTOR EXTRACELLULAR VESTIBULE RESIDUES CONTRIBUTING TO RECEPTOR STRUCTURE AND CHANNEL GATING	127
Bianchi A.	2
S7-02GUANOSINE/GUANYLATE-DEPENDENT REGULATION OF SIGNAL TRANSDUCTION IN CANCER CELLS	55
Bianchi C.	233
P.34REGULATION OF THE UBIQUITIN-PROTEASOME SYSTEM BY P2X7 RECEPTOR, RELEVANCE ON NEUROLOGICAL PATHOLOGIES.	160
Blackburn M.	233
S7-01ADENOSINE AT THE CROSS-ROADS OF LUNG FIBROSIS AND PULMONARY HYPERTENSION	54
Blanch M.	233
S2-05DRUG-INDUCED CARDIOVASCULAR TOXICITY MEDIATED BY P2X7 RECEPTORS: THE EXAMPLE OF ABACAVIR	33
Blandizzi C.	233
P8. PURINERGIC SIGNALING IN IMMUNOLOGY AND INFLAMMATIONP.74THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF AR170, A POTENT AND SELECTIVE A3 RECEPTOR AGONIST, IN A RAT MODEL OF COLITIS	200
P.97ADENOSINE A2B RECEPTORS ON ENTERIC GLIA MEDIATE COLONIC DYSMOTILITY ASSOCIATED WITH HIGH FAT DIET-INDUCED OBESITY	223
Blank B.	233
P.26MONO-ADP-RIBOSYLATION OF CD73 – A NEW LEVEL OF PURI-NERGIC CONTROL	152
Blank N.	233
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
Blum D.	233
Simposium 3: PURINERGIC RECEPTORS AS FUTURE TARGETS IN ALZHEIMER’S DISEASE?	34
S6-02A NEW CONDITIONAL MODEL TO STUDY ADENOSINE A2AR DYSFUNCTION IN ALZHEIMER’S DISEASE	50
P.62BENEFICIAL EFFECTS OF P2X7R DEFICIENCY IN A MOUSE MODEL OF TAUOPATHY	188
P.63NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES MEMORY DEFICITS IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE.	189
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Boeynaems J.	233
P.64THE ADP RECEPTOR P2Y13 IS SELECTIVELY EXPRESSED IN BRAIN MICROGLIA AND CONSTITUTIVELY ATTENUATES HIPPOCAMPAL NEUROGENESIS	190
Bogdanov A.	233
S13-02ATP IN ASTROGLIAL CONTROL OF SYNAPTIC PLASTICITY IN AGEING AND AD	85
Bonasera D.	233
P.12DEVELOPMENT OF A LIVE CELL NANOBRET BINDING ASSAY FOR ADENOSINE A2B RECEPTORS	138
Bonfanti E.	233
S16-01EFFECTS OF ATP-INDUCED MICROGLIAL EXTRACELLULAR VESICLES ON OLIGODENDROCYTE PROGENITORS IN CEREBRAL ISCHEMIA	99
S16-04ACTIVATED MICROGLIA REGULATE THE RESPONSE OF OLIGODENDROCYTE PROGENITORS EXPRESSING THE P2Y-LIKE RECEPTOR GPR17 FOLLOWING CEREBRAL ISCHEMIA	102
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
P.55MICROGLIA VERSUS MACROPHAGE EFFECTS ON OLIGODENDROCYTE PRECURSOR CELLS: ROLE OF EXTRACELLULAR VESICLES	181
Bontempi B.	233
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Borroto D.	233
S9-03ADENOSINE HETERORECEPTOR COMPLEXES IN THE BASAL GANGLIA ARE IMPLICATED IN PARKINSON DISEASE AND ITS TREATMENT	66
P.58ADENOSINE A2A RECEPTOR ANTAGONISTS POTENTIATE CANNABINOID SIGNALING IN MICROGLIA	184
Boscá L.	233
S2-02CROSSROAD BETWEEN BIOACTIVE LIPIDS AND PURINERGIC SIGNALLING IN MACROPHAGES	30
Bouazzi R.	233
S10-03ROLE OF PURINERGIC SIGNALIN IN PANCREATIC CANCER	71
Boué E.	233
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Simposium 8: NEW INSIGHTS IN P2X RECEPTOR STRUCTURE-FUNCTION	58
Boutillier A.	233
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Brauneck F.	233
P7. PURINERGIC SIGNALING IN THE TUMORGROWTH ANDMETASTASISP.68CHARACTIZATION OF CD39 EXPRESSION ON T CELLS IN ACUTE MYELOID LEUKEMIA	194
Brea J.	233
P2. PHARMACOLOGY AND BIOCHEMISTRY OF P1 RECEPTORSP.092-ARYLADENINE DERIVATIVES AS POTENT SCAFFOLDS FOR A1, A3 AND DUAL A1/A3 ADENOSINE RECEPTOR ANTAGONISTS: SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS	135
P.11A2B ANTAGONIST AS ANTIMETASTATIC AGENTS: DESIGN, SYNTHESIS AND OPTIMIZATION OF NOVEL CHEMOTYPES	137
Breithausen B.	233
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
Brendler J.	233
P.98RENAL PAPILLA EXPRESSES HIGH LEVELS OF THE UDP-GLUCOSE RECEPTOR P2RY14	224
Brisson L.	233
S10-01THE ROLE OF THE P2X4 RECEPTOR IN BREAST CANCER	69
Bröker V.	233
S4-02ENHANCED OSTEOGENESIS AND ANGIOGENESIS FOR PUTATIVE BONE GRAFTS BY ACTIVATING PURINERGIC RECEPTOR SIGNALING DURING MESENCHYMAL STEM CELL DIFFERENTIATION	41
S9-02ROLE OF ADENOSINE IN METABOLISM	65
P.57ADENOSINE A2B RECEPTORS AND SPHINGOSINE KINASE/SPHINGOSINE 1-PHOSPHATE SIGNALING AXIS CONTROL MATURATION OF OLIGODENDROCYTE PRECURSOR CELLS IN VITRO	183
S11-04STRUCTURAL INSIGHTS INTO MODIFICATIONS TO THE ATP MOLECULE TUNING ITS AGONIST-TO-ANTAGONIST ACTIVITY AT THE P2X RECEPTORS	77
P.83NEW 4’-TETRAZOLYL ADENOSINE DERIVATIVES AS POTENTIAL AGENTS FOR WOUND HEALING	209
P.62BENEFICIAL EFFECTS OF P2X7R DEFICIENCY IN A MOUSE MODEL OF TAUOPATHY	188
P.63NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES MEMORY DEFICITS IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE.	189
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
P.65PROTECTIVE EFFECT OF THE ADENOSINE A2B RECEPTOR AGONIST, BAY60-6583, IN A RAT MODEL OF TRANSIENT CEREBRAL ISCHEMIA.	191
S13-03PURINERGIC SIGNALLING IN THE OLIGODENDROGLIAL LINEAGE	86
P.98RENAL PAPILLA EXPRESSES HIGH LEVELS OF THE UDP-GLUCOSE RECEPTOR P2RY14	224
S4-01INFLUENCE OF DIFFERENT PURINE RECEPTORS ON THE DIFFERENTIATION POTENTIAL OR MALIGNANCY OF NORMAL OR CANCEROUS MESENCHYMAL STEM CELLS, RESPECTIVELY	40
Simposium 12: GUANINE-BASED PURINES IN HEALTH AND DISEASE	78
S12-04CONFLICTING EFFECTS OF GUANOSINE, GUANINE AND THEIR METABOLIZING ENZYMES ON NEUROPROTECTION AND TUMOR CELL PROLIFERATION	82
P.02P2X7 RECEPTOR ACTIVATION INCREASESMESENCHYMAL TRANSDIFFERENTIATION AND INVASIVENESS OF GLIOBLASTOMA-DERIVED STEM-LIKE CELLS	128
P.15P2X7 RECEPTOR MODULATES THE OSTEOGENIC DIFFERENTIATION OF STROMAL STEM CELLS FROM HUMAN ADIPOSE TISSUE	141
P.42INVESTIGATING THE ROLE OF GUANOSINE IN HUMAN NEUROBLASTOMA CELL DIFFERENTIATION.	168
P.81ROLE OF CD73 IN THE DEVELOPMENT OF MURINE ALLERGIC ASTHMA	207
P.63NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES MEMORY DEFICITS IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE.	189
P.45ARE micro-RNAs THERAPEUTIC TARGETS FOR SPINAL CORD INJURY EXCITOTOXICITY? microRNA-135a-5p REDUCES P2X7-DEPENDENT RISE IN INTRACELLULAR CALCIUM AND PROTECTS AGAINST EXCITOTOXICITY.	171
P.88POLYPHENOLS INCREASE ATP RELEASE AND NO PRODUCTION BY SEPARATE MECHANISMS IN MESENTERIC ENDOTHELIAL CELL CULTURES.	214
P.41THE EFFECT OF P2X7 RECEPTOR DEFICIENCY ON C-FOS ACTIVATION IN AN ACUTE PCP INDUCED SCHIZOPHRENIA MODEL IN MICE	167
P.16DESIGN, SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF NOVEL P2X7R ANTAGONISTS POTENTIALLY TARGETING THE CNS	142
S12-03IMPACT OF IMP-GMP SPECIFIC 5'-NUCLEOTIDASE ON METABOLIC REGULATION AND DRUG RESISTANCE IN TUMORS	81
S3-03ATP-DERIVED ADENOSINE CONTROLS SYNAPTIC AND MEMORY DYSFUNCTION IN β-AMYLOID MODELS OF ALZHEIMER’S DISEASE	37
P.10PHARMACOLOGICAL BLOCKADE OF ADENOSINE A2A RECEPTORS RECOVERS MOTOR LEARNING AND GRIP STRENGTH DEFICITS IN AN ANGELMAN SYNDROME MOUSE MODEL	136
P.76ADENOSINE A2A RECEPTOR MODULATION OF MICROGLIA MORPHOLOGIC REMODELLING IN EARLY NEURODEVELOPMENT - GENDER BIAS IN PHYSIOLOGY AND PSYCHIATRIC DISORDERS	202
P.58ADENOSINE A2A RECEPTOR ANTAGONISTS POTENTIATE CANNABINOID SIGNALING IN MICROGLIA	184
P.21ANALYSIS OF CD73 IN SERUM OF CANCER PATIENTS AND HEALTHY DONORS	147
P.97ADENOSINE A2B RECEPTORS ON ENTERIC GLIA MEDIATE COLONIC DYSMOTILITY ASSOCIATED WITH HIGH FAT DIET-INDUCED OBESITY	223
P.39ADENOSINE-MEDIATED CONTROL OF SYNAPTIC AND BEHAVIOURAL ACTIONS OF CANNABINOIDS	165
S4-01INFLUENCE OF DIFFERENT PURINE RECEPTORS ON THE DIFFERENTIATION POTENTIAL OR MALIGNANCY OF NORMAL OR CANCEROUS MESENCHYMAL STEM CELLS, RESPECTIVELY	40
S12-04CONFLICTING EFFECTS OF GUANOSINE, GUANINE AND THEIR METABOLIZING ENZYMES ON NEUROPROTECTION AND TUMOR CELL PROLIFERATION	82
P.02P2X7 RECEPTOR ACTIVATION INCREASESMESENCHYMAL TRANSDIFFERENTIATION AND INVASIVENESS OF GLIOBLASTOMA-DERIVED STEM-LIKE CELLS	128
P.15P2X7 RECEPTOR MODULATES THE OSTEOGENIC DIFFERENTIATION OF STROMAL STEM CELLS FROM HUMAN ADIPOSE TISSUE	141
P.42INVESTIGATING THE ROLE OF GUANOSINE IN HUMAN NEUROBLASTOMA CELL DIFFERENTIATION.	168
P.62BENEFICIAL EFFECTS OF P2X7R DEFICIENCY IN A MOUSE MODEL OF TAUOPATHY	188
P.63NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES MEMORY DEFICITS IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE.	189
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
P2. PHARMACOLOGY AND BIOCHEMISTRY OF P1 RECEPTORSP.092-ARYLADENINE DERIVATIVES AS POTENT SCAFFOLDS FOR A1, A3 AND DUAL A1/A3 ADENOSINE RECEPTOR ANTAGONISTS: SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS	135
P.39ADENOSINE-MEDIATED CONTROL OF SYNAPTIC AND BEHAVIOURAL ACTIONS OF CANNABINOIDS	165
P.30NICOTINIC α7 RECEPTOR-INDUCED ADENOSINE RELEASE FROM PERISYNAPTIC SCHWANN CELLS CONTROLS ACETYLCHOLINE SPILLOVER FROM THE RAT MOTOR ENDPLATE	156
S16-01EFFECTS OF ATP-INDUCED MICROGLIAL EXTRACELLULAR VESICLES ON OLIGODENDROCYTE PROGENITORS IN CEREBRAL ISCHEMIA	99
S16-04ACTIVATED MICROGLIA REGULATE THE RESPONSE OF OLIGODENDROCYTE PROGENITORS EXPRESSING THE P2Y-LIKE RECEPTOR GPR17 FOLLOWING CEREBRAL ISCHEMIA	102
P2. PHARMACOLOGY AND BIOCHEMISTRY OF P1 RECEPTORSP.092-ARYLADENINE DERIVATIVES AS POTENT SCAFFOLDS FOR A1, A3 AND DUAL A1/A3 ADENOSINE RECEPTOR ANTAGONISTS: SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS	135
P.57ADENOSINE A2B RECEPTORS AND SPHINGOSINE KINASE/SPHINGOSINE 1-PHOSPHATE SIGNALING AXIS CONTROL MATURATION OF OLIGODENDROCYTE PRECURSOR CELLS IN VITRO	183
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
P.57ADENOSINE A2B RECEPTORS AND SPHINGOSINE KINASE/SPHINGOSINE 1-PHOSPHATE SIGNALING AXIS CONTROL MATURATION OF OLIGODENDROCYTE PRECURSOR CELLS IN VITRO	183
P.81ROLE OF CD73 IN THE DEVELOPMENT OF MURINE ALLERGIC ASTHMA	207
P.62BENEFICIAL EFFECTS OF P2X7R DEFICIENCY IN A MOUSE MODEL OF TAUOPATHY	188
P.48P2X7 RECEPTOR ANTAGONISM WITH JNJ-47965567 REDUCED BODY WEIGHT LOSS AND DELAYED DISEASE ONSET IN FEMALE AMYOTROPHIC LATERAL SCLEROSIS SOD1G93A MICE	174
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
S10-01THE ROLE OF THE P2X4 RECEPTOR IN BREAST CANCER	69
Simposium 21: TEACHING CAFFEINE NEW TRICKS FOR OLD PROBLEMS IN PARKINSON'S DISEASE	125
P.54ROLE OF ASTROCYTIC ADENOSINE A2A RECEPTORS IN THE FACILITATION OF SYNAPTIC PLASTICITY IN CORTICO-STRIATAL SYNAPSES	180
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
S16-05THE SELECTIVE STIMULATION OF ADENOSINE A3 RECEPTOR INHIBITS N-TYPE CA2+ CURRENTS IN RAT DORSAL ROOT GANGLION NEURONS	103
P.57ADENOSINE A2B RECEPTORS AND SPHINGOSINE KINASE/SPHINGOSINE 1-PHOSPHATE SIGNALING AXIS CONTROL MATURATION OF OLIGODENDROCYTE PRECURSOR CELLS IN VITRO	183
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
P.60MITOCHONDRIA ARE A KEY TARGET OF AMYLOID β-DEPENDENT DAMAGE IN MOUSE MICROGLIAL CELLS: ROLE OF THE P2X7 RECEPTOR AND PROTECTION BY NIMODIPINE.	186
P.11A2B ANTAGONIST AS ANTIMETASTATIC AGENTS: DESIGN, SYNTHESIS AND OPTIMIZATION OF NOVEL CHEMOTYPES	137
S10-03ROLE OF PURINERGIC SIGNALIN IN PANCREATIC CANCER	71
P.81ROLE OF CD73 IN THE DEVELOPMENT OF MURINE ALLERGIC ASTHMA	207
Simposium 4: HOW PURINERGIC SIGNALING INFLUENCES THE ACTIVITY OF HUMAN MESENCHYMAL STROMAL/STEM CELLS	39
S4-01INFLUENCE OF DIFFERENT PURINE RECEPTORS ON THE DIFFERENTIATION POTENTIAL OR MALIGNANCY OF NORMAL OR CANCEROUS MESENCHYMAL STEM CELLS, RESPECTIVELY	40
S12-04CONFLICTING EFFECTS OF GUANOSINE, GUANINE AND THEIR METABOLIZING ENZYMES ON NEUROPROTECTION AND TUMOR CELL PROLIFERATION	82
P.02P2X7 RECEPTOR ACTIVATION INCREASESMESENCHYMAL TRANSDIFFERENTIATION AND INVASIVENESS OF GLIOBLASTOMA-DERIVED STEM-LIKE CELLS	128
P.15P2X7 RECEPTOR MODULATES THE OSTEOGENIC DIFFERENTIATION OF STROMAL STEM CELLS FROM HUMAN ADIPOSE TISSUE	141
P.42INVESTIGATING THE ROLE OF GUANOSINE IN HUMAN NEUROBLASTOMA CELL DIFFERENTIATION.	168
S16-01EFFECTS OF ATP-INDUCED MICROGLIAL EXTRACELLULAR VESICLES ON OLIGODENDROCYTE PROGENITORS IN CEREBRAL ISCHEMIA	99
S16-04ACTIVATED MICROGLIA REGULATE THE RESPONSE OF OLIGODENDROCYTE PROGENITORS EXPRESSING THE P2Y-LIKE RECEPTOR GPR17 FOLLOWING CEREBRAL ISCHEMIA	102
CPL-05Lecture in Honour Prof Bertil FredholmLIGHTING UP ADENOSINE RECEPTORSFrancisco Ciruela Alférez. Universidad de Barcelona, Spain.	20
Simposium 12: GUANINE-BASED PURINES IN HEALTH AND DISEASE	78
S12-01GUANOSINE-INDUCED NEUROPROTECTION: A ROLE FOR ADENOSINE RECEPTOR OLIGOMERS?	79
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
P.36ADENOSINERGIC SYSTEM: NOVEL THERAPEUTIC TARGET FOR RETT SYNDROME	162
S7-01ADENOSINE AT THE CROSS-ROADS OF LUNG FIBROSIS AND PULMONARY HYPERTENSION	54
S10-02P2X7 RECEPTOR IS A KEY REGULATOR OF ATP CONTENT AND IMMUNE INFILTRATION IN THE TUMOR MICROENVIRONMENT	70
P.57ADENOSINE A2B RECEPTORS AND SPHINGOSINE KINASE/SPHINGOSINE 1-PHOSPHATE SIGNALING AXIS CONTROL MATURATION OF OLIGODENDROCYTE PRECURSOR CELLS IN VITRO	183
P8. PURINERGIC SIGNALING IN IMMUNOLOGY AND INFLAMMATIONP.74THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF AR170, A POTENT AND SELECTIVE A3 RECEPTOR AGONIST, IN A RAT MODEL OF COLITIS	200
S11-02THE MOLECULAR DYNAMICS OF ION CONDUCTION IN P2X RECEPTORS	75
P.96PANNEXIN1 KO MICE ARE IRRESPONSIVE TO TENOFOVIR INDUCED BONE LOSS	222
P.100TENOFOVIR CAUSES BONE LOSS VIA DECREASED BONE FORMATION AND INCREASED BONE RESORPTION, WHICH CAN BE COUNTERACTED BY ADENOSINE A2A RECEPTOR IN MICE	226
P.33IDENTIFICATION OF P2X7-DEPENDENT TRANSCRIPTOME AFTER SEIZURES	159
P.40CONTEXT-SPECIFIC SWITCH FROM ANTI- TO PRO-EPILEPTOGENIC FUNCTION OF THE P2Y1 RECEPTOR IN EXPERIMENTAL EPILEPSY	166
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
S16-05THE SELECTIVE STIMULATION OF ADENOSINE A3 RECEPTOR INHIBITS N-TYPE CA2+ CURRENTS IN RAT DORSAL ROOT GANGLION NEURONS	103
P.57ADENOSINE A2B RECEPTORS AND SPHINGOSINE KINASE/SPHINGOSINE 1-PHOSPHATE SIGNALING AXIS CONTROL MATURATION OF OLIGODENDROCYTE PRECURSOR CELLS IN VITRO	183
P.31INHIBITION OF THE DOPAMINE TRANSPORTER AS AN ANIMAL MODEL OF MANIA MODULATES ADENOSINE RECEPTORS AND INFLAMMATORY RESPONSES IN THE BRAIN	157
P2. PHARMACOLOGY AND BIOCHEMISTRY OF P1 RECEPTORSP.092-ARYLADENINE DERIVATIVES AS POTENT SCAFFOLDS FOR A1, A3 AND DUAL A1/A3 ADENOSINE RECEPTOR ANTAGONISTS: SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS	135
P.30NICOTINIC α7 RECEPTOR-INDUCED ADENOSINE RELEASE FROM PERISYNAPTIC SCHWANN CELLS CONTROLS ACETYLCHOLINE SPILLOVER FROM THE RAT MOTOR ENDPLATE	156
P10. PURINERGIC SIGNALING IN RENAL, GASTROINTESTINAL AND MUSCULOSKELETAL SYSTEMP.92ADP-INDUCED P2Y1-MEDIATED OSTEOGENESIS IS DOWNREGULATED BY OVEREXPRESSED P2Y12 AND P2Y13 RECEPTORS IN POSTMENOPAUSAL MESENCHYMAL STEM CELLS	218
P.93ADENOSINE A2A RECEPTOR ACTIVATION PROMOTES FIBROSIS BY FAVORING PANNEXIN-1 OVEREXPRESSION IN HUMAN SUBCUTANEOUS FIBROBLASTS	219
P.94URINARY ATP CONCENTRATION IS RELATED TO DETRUSOR PRESSURE DURING VOIDING	220
P.95β3-ADRENOCEPTOR COUPLING TO EPAC1 AND PKC PROMOTES ADENOSINE RELEASE VIA ENT1 LEADING TO INHIBITION OF CHOLINERGIC NEUROTRANSMISSION IN THE HUMAN BLADDER	221
P.102SIGNIFICANCE OF ADENOSINE A2A RECEPTORS IN THE COMMENSAL-PATHOGEN SWITCH IN THE ELDERLY GUT	228
P.95β3-ADRENOCEPTOR COUPLING TO EPAC1 AND PKC PROMOTES ADENOSINE RELEASE VIA ENT1 LEADING TO INHIBITION OF CHOLINERGIC NEUROTRANSMISSION IN THE HUMAN BLADDER	221
P10. PURINERGIC SIGNALING IN RENAL, GASTROINTESTINAL AND MUSCULOSKELETAL SYSTEMP.92ADP-INDUCED P2Y1-MEDIATED OSTEOGENESIS IS DOWNREGULATED BY OVEREXPRESSED P2Y12 AND P2Y13 RECEPTORS IN POSTMENOPAUSAL MESENCHYMAL STEM CELLS	218
P.93ADENOSINE A2A RECEPTOR ACTIVATION PROMOTES FIBROSIS BY FAVORING PANNEXIN-1 OVEREXPRESSION IN HUMAN SUBCUTANEOUS FIBROBLASTS	219
S20-03ADENOSINE METABOLISM AND RECEPTORS IN OSTEOARTHRITIS: TARGETING A2A RECEPTORS TO REVERSE INFLAMMAGING	122
P.96PANNEXIN1 KO MICE ARE IRRESPONSIVE TO TENOFOVIR INDUCED BONE LOSS	222
P.100TENOFOVIR CAUSES BONE LOSS VIA DECREASED BONE FORMATION AND INCREASED BONE RESORPTION, WHICH CAN BE COUNTERACTED BY ADENOSINE A2A RECEPTOR IN MICE	226
S3-03ATP-DERIVED ADENOSINE CONTROLS SYNAPTIC AND MEMORY DYSFUNCTION IN β-AMYLOID MODELS OF ALZHEIMER’S DISEASE	37
S13-01ATP AS A DANGER SIGNAL IN THE BRAIN	84
Simposium 15: KEY ROLES OF ADENOSINE A2A RECEPTORS THROUGHOUT BRAIN DEVELOPMENT	93
S15-02CORTICAL NEURONAL MIGRATION ENTAILS A2A RECEPTOR-DRIVEN NEURONAL POLARIZATION AND AXON FORMATION	95
P.10PHARMACOLOGICAL BLOCKADE OF ADENOSINE A2A RECEPTORS RECOVERS MOTOR LEARNING AND GRIP STRENGTH DEFICITS IN AN ANGELMAN SYNDROME MOUSE MODEL	136
P.19EXTRACELLULAR NUCLEOTIDE METABOLISM IN THE CONTEXT OF YEAST-HOST INTERACTION	145
P.54ROLE OF ASTROCYTIC ADENOSINE A2A RECEPTORS IN THE FACILITATION OF SYNAPTIC PLASTICITY IN CORTICO-STRIATAL SYNAPSES	180
P.76ADENOSINE A2A RECEPTOR MODULATION OF MICROGLIA MORPHOLOGIC REMODELLING IN EARLY NEURODEVELOPMENT - GENDER BIAS IN PHYSIOLOGY AND PSYCHIATRIC DISORDERS	202
P.102SIGNIFICANCE OF ADENOSINE A2A RECEPTORS IN THE COMMENSAL-PATHOGEN SWITCH IN THE ELDERLY GUT	228
S10-02P2X7 RECEPTOR IS A KEY REGULATOR OF ATP CONTENT AND IMMUNE INFILTRATION IN THE TUMOR MICROENVIRONMENT	70
P8. PURINERGIC SIGNALING IN IMMUNOLOGY AND INFLAMMATIONP.74THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF AR170, A POTENT AND SELECTIVE A3 RECEPTOR AGONIST, IN A RAT MODEL OF COLITIS	200
P.97ADENOSINE A2B RECEPTORS ON ENTERIC GLIA MEDIATE COLONIC DYSMOTILITY ASSOCIATED WITH HIGH FAT DIET-INDUCED OBESITY	223
S12-04CONFLICTING EFFECTS OF GUANOSINE, GUANINE AND THEIR METABOLIZING ENZYMES ON NEUROPROTECTION AND TUMOR CELL PROLIFERATION	82
Simposium 11: STRUCTURAL INSIGHTS INTO LIGAND BINDING AND DYNAMICS OF P2X RECEPTORS	73
S11-04STRUCTURAL INSIGHTS INTO MODIFICATIONS TO THE ATP MOLECULE TUNING ITS AGONIST-TO-ANTAGONIST ACTIVITY AT THE P2X RECEPTORS	77
P8. PURINERGIC SIGNALING IN IMMUNOLOGY AND INFLAMMATIONP.74THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF AR170, A POTENT AND SELECTIVE A3 RECEPTOR AGONIST, IN A RAT MODEL OF COLITIS	200
P.83NEW 4’-TETRAZOLYL ADENOSINE DERIVATIVES AS POTENTIAL AGENTS FOR WOUND HEALING	209
P.47PHYSICAL AND FUNCTIONAL INTERACTION BETWEEN GPR17 AND THE CHEMOKINE RECEPTOR 2: A PROMISING TOOL FOR MANAGING REMYELINATION	173
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
S2-02CROSSROAD BETWEEN BIOACTIVE LIPIDS AND PURINERGIC SIGNALLING IN MACROPHAGES	30
S14-03INVOLVEMENT OF P2X7 RECEPTOR ON THE ALZHEIMER DISEASE PROGRESSION, THERAPEUTIC IMPLICATIONS	91
P.34REGULATION OF THE UBIQUITIN-PROTEASOME SYSTEM BY P2X7 RECEPTOR, RELEVANCE ON NEUROLOGICAL PATHOLOGIES.	160
P.38CONTROL OF THE BLOOD-BRAIN BARRIER INTEGRITY DURING SEIZURES VIA THE ATP-GATED P2X7 RECEPTOR	164
P.40CONTEXT-SPECIFIC SWITCH FROM ANTI- TO PRO-EPILEPTOGENIC FUNCTION OF THE P2Y1 RECEPTOR IN EXPERIMENTAL EPILEPSY	166
de Diego A.	234
P.16DESIGN, SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF NOVEL P2X7R ANTAGONISTS POTENTIALLY TARGETING THE CNS	142
de Leo G.	234
P.50A POSSIBLE IMPLICATION OF THE ATP-GATED P2X7 RECEPTOR ON STATUS EPILEPTICUS-INDUCED ABERRANT NEUROGENESIS	176
de los Ríos C.	234
P.16DESIGN, SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF NOVEL P2X7R ANTAGONISTS POTENTIALLY TARGETING THE CNS	142
de Marchi E.	234
S10-02P2X7 RECEPTOR IS A KEY REGULATOR OF ATP CONTENT AND IMMUNE INFILTRATION IN THE TUMOR MICROENVIRONMENT	70
P.73P2X7 RECEPTOR INFLUENCES METASTATIC POTENTIAL AND VESICULAR RELEASE IN MELANOMA	199
de Pascual R	234
P.16DESIGN, SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF NOVEL P2X7R ANTAGONISTS POTENTIALLY TARGETING THE CNS	142
de Sá A.	234
P.10PHARMACOLOGICAL BLOCKADE OF ADENOSINE A2A RECEPTORS RECOVERS MOTOR LEARNING AND GRIP STRENGTH DEFICITS IN AN ANGELMAN SYNDROME MOUSE MODEL	136
Delarasse C.	234
P.62BENEFICIAL EFFECTS OF P2X7R DEFICIENCY IN A MOUSE MODEL OF TAUOPATHY	188
Delatour B.	234
P.62BENEFICIAL EFFECTS OF P2X7R DEFICIENCY IN A MOUSE MODEL OF TAUOPATHY	188
Deleau A.	234
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Delekate A	234
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
Delicado E.	234
Simposium 2: NEW INSIGHTS INTO PURINERGIC SIGNALING	28
S2-04CROSS-TALK BETWEEN P2 RECEPTORS AND TYROSINE KINASE RECEPTORS IN CEREBELLAR ASTROCYTES	32
S5-03LIVE IMAGING AND SINGLE CELL TRACKING REVEALS CELL DYNAMICS FROM EARLY CEREBELLAR NEURAL STEM CELLS. ROLE OF VNUT IN THEIR LINEAGE PROGRESSION.	47
S10-04REGULATION OF P2X7 RECEPTOR GENE EXPRESSION IN NEUROBLASTOMA CELLS	72
P5. VESICULAR AND MEMBRANE TRANSPORTERSP.28ANALYSIS OF THE EXPRESION AND FUNCTION OF VNUT IN POSTNATAL CEREBELLUM	154
P.53P2X7 RECEPTOR REGULATES THE INDUCIBLE NUCLEAR DUAL-SPECIFICITY PHOSPHATASE 1 IN RAT CEREBELLAR ASTROCYTES	179
P.59P2X7 AND BDNF RECEPTORS CONVERGE TO SHAPE ERK SIGNALLING IN NEURONS THROUGH THE MODULATION OF ERK-DIRECTED PROTEIN PHOSPHATASES	185
P.71INHIBITION OF DUAL-SPECIFICITY PHOSPHATASES PROMOTES P2X7 RECEPTOR EXPRESSION IN NEUROBLASTOMA CELLS IN A p38-DEPENDENT MANNER	197
Deluc T.	234
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Dempsey E.	234
S7-04EXTRACELLULAR ATP REGULATES ANGIOGENIC RESPONSES IN VASA VASORUM ENDOTHELIAL CELLS VIA THE ACTIVATION OF PI3K-AKT-mTOR SIGNALING AXIS AND C-JUN, FOXO3A, AND C-MYC TRANSCRIPTION FACTORS	57
Dénes A.	234
P.49CONTRIBUTION OF P2Y12 RECEPTORS TO ANIMAL MODEL OF NTG-INDUCED MIGRAINE-ASSOCIATED PAIN	175
Dentler H.	235
P.08POINT MUTATIONS IN P2X7 RECEPTORS	134
Dettori I.	235
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
P.57ADENOSINE A2B RECEPTORS AND SPHINGOSINE KINASE/SPHINGOSINE 1-PHOSPHATE SIGNALING AXIS CONTROL MATURATION OF OLIGODENDROCYTE PRECURSOR CELLS IN VITRO	183
P.65PROTECTIVE EFFECT OF THE ADENOSINE A2B RECEPTOR AGONIST, BAY60-6583, IN A RAT MODEL OF TRANSIENT CEREBRAL ISCHEMIA.	191
Deussing J.M.	235
S14-04VALIDATING P2X7R AS RISK FACTOR FOR MOOD DISORDERS	92
Di Cesare L.	235
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
P8. PURINERGIC SIGNALING IN IMMUNOLOGY AND INFLAMMATIONP.74THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF AR170, A POTENT AND SELECTIVE A3 RECEPTOR AGONIST, IN A RAT MODEL OF COLITIS	200
Di Iorio P.	235
S4-01INFLUENCE OF DIFFERENT PURINE RECEPTORS ON THE DIFFERENTIATION POTENTIAL OR MALIGNANCY OF NORMAL OR CANCEROUS MESENCHYMAL STEM CELLS, RESPECTIVELY	40
S12-04CONFLICTING EFFECTS OF GUANOSINE, GUANINE AND THEIR METABOLIZING ENZYMES ON NEUROPROTECTION AND TUMOR CELL PROLIFERATION	82
P.02P2X7 RECEPTOR ACTIVATION INCREASESMESENCHYMAL TRANSDIFFERENTIATION AND INVASIVENESS OF GLIOBLASTOMA-DERIVED STEM-LIKE CELLS	128
P.15P2X7 RECEPTOR MODULATES THE OSTEOGENIC DIFFERENTIATION OF STROMAL STEM CELLS FROM HUMAN ADIPOSE TISSUE	141
P.42INVESTIGATING THE ROLE OF GUANOSINE IN HUMAN NEUROBLASTOMA CELL DIFFERENTIATION.	168
Di Virgilio F.	235
S10-02P2X7 RECEPTOR IS A KEY REGULATOR OF ATP CONTENT AND IMMUNE INFILTRATION IN THE TUMOR MICROENVIRONMENT	70
P.60MITOCHONDRIA ARE A KEY TARGET OF AMYLOID β-DEPENDENT DAMAGE IN MOUSE MICROGLIAL CELLS: ROLE OF THE P2X7 RECEPTOR AND PROTECTION BY NIMODIPINE.	186
P.73P2X7 RECEPTOR INFLUENCES METASTATIC POTENTIAL AND VESICULAR RELEASE IN MELANOMA	199
P.80INVESTIGATION ON THE ROLE OF THE P2X7R-NLRP3-IL-1β AXIS IN THE PATHOGENESIS OF HIDRADENITIS SUPPURATIVA	206
P.85THE P2X7 RECEPTOR IS SHED INTO CIRCULATION AND CORRELATES WITH C-REACTIVE PROTEIN LEVELS	211
Dias R.	235
P.51FACILITATION OF SYNAPTIC, BUT NOT EXTRASYNAPTIC, NMDA CURRENTS IN CA1 PYRAMIDAL NEURONS BY ADENOSINE A2AR IN YOUNG ADULT RATS.	177
Díaz J.	235
P.46AGE-RELATED NUCLEAR TRANSLOCATION OF P2X6 SUBUNIT MODIFIES SPLICING ACTIVITY INTERACTING WITH SPLICING FACTOR 3A1	172
Diaz M.	235
Simposium 14: P2X7: A COMMON TARGET FOR BRAIN DISEASES?	88
S14-03INVOLVEMENT OF P2X7 RECEPTOR ON THE ALZHEIMER DISEASE PROGRESSION, THERAPEUTIC IMPLICATIONS	91
P.34REGULATION OF THE UBIQUITIN-PROTEASOME SYSTEM BY P2X7 RECEPTOR, RELEVANCE ON NEUROLOGICAL PATHOLOGIES.	160
P.45ARE micro-RNAs THERAPEUTIC TARGETS FOR SPINAL CORD INJURY EXCITOTOXICITY? microRNA-135a-5p REDUCES P2X7-DEPENDENT RISE IN INTRACELLULAR CALCIUM AND PROTECTS AGAINST EXCITOTOXICITY.	171
P.46AGE-RELATED NUCLEAR TRANSLOCATION OF P2X6 SUBUNIT MODIFIES SPLICING ACTIVITY INTERACTING WITH SPLICING FACTOR 3A1	172
DiLauro C.	235
S14-03INVOLVEMENT OF P2X7 RECEPTOR ON THE ALZHEIMER DISEASE PROGRESSION, THERAPEUTIC IMPLICATIONS	91
P.34REGULATION OF THE UBIQUITIN-PROTEASOME SYSTEM BY P2X7 RECEPTOR, RELEVANCE ON NEUROLOGICAL PATHOLOGIES.	160
Ding Z.	235
P9. PURINERGIC SIGNALING IN THE CARDIOVASCULAR SYSTEMP.86REGULATION OF IL-6 FORMATION IN THE HEART BY CD73-DERIVED ADENOSINE	212
P.90PURINE METABOLISM IN CARDIAC FIBROBLASTS AND EPICARDIUM-DERIVED CELLS, SIMULTANEOUSLY ISOLATED FROM THE INFARCTED MOUSE HEART	216
P.91IMPACT OF CD73-DERIVED ADENOSINE ON THE CELL-TYPE SPECIFIC CYTOKINE RESPONSE IN THE INFARCTED MURINE HEART	217
Diógenes M.	235
P.36ADENOSINERGIC SYSTEM: NOVEL THERAPEUTIC TARGET FOR RETT SYNDROME	162
Dobelmann C.	235
P.24URIDINE- AND CYTIDINE-BASED ECTO-5ꞌ-NUCLEOTIDASE-INHIBITORS: A NOVEL CLASS OF HIGHLY ACTIVE AND SELECTIVE CD73-INHIBITORS	150
Dolezel P.	235
P.72EFFECT OF WEAK BASE DRUGS ON LYSOSOMAL CAPACITY OF CANCER CELLS: POSSIBLE INVOLVEMENT OF P2X4 RECEPTOR.	198
Domercq M.	235
Simposium 19: IMPACT OF PURINERGIC SIGNALLING IN MULTIPLE SCLEROSIS PATHOLOGY	114
S19-04P2X4 RECEPTOR CONTROLS MICROGLIA ACTIVATION AND FAVOURS REMYELINATION IN AUTOIMMUNE ENCEPHALITIS	118
Donoso F.	235
P.88POLYPHENOLS INCREASE ATP RELEASE AND NO PRODUCTION BY SEPARATE MECHANISMS IN MESENTERIC ENDOTHELIAL CELL CULTURES.	214
Donoso M.	235
P.88POLYPHENOLS INCREASE ATP RELEASE AND NO PRODUCTION BY SEPARATE MECHANISMS IN MESENTERIC ENDOTHELIAL CELL CULTURES.	214
Doudnikoff E.	235
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Drummond R.	235
P.17CHARACTERISATION OF P2Y2 RECEPTORS IN HUMAN VASCULAR ENDOTHELIAL CELLS USING AR-C118925XX, A POTENT AND SELECTIVE P2Y2 ANTAGONIST	143
Duarte J.	235
P.76ADENOSINE A2A RECEPTOR MODULATION OF MICROGLIA MORPHOLOGIC REMODELLING IN EARLY NEURODEVELOPMENT - GENDER BIAS IN PHYSIOLOGY AND PSYCHIATRIC DISORDERS	202
Duarte S.	235
P.36ADENOSINERGIC SYSTEM: NOVEL THERAPEUTIC TARGET FOR RETT SYNDROME	162
Dumoulin M.	235
P.63NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES MEMORY DEFICITS IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE.	189
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Duncker D.	235
P.89THE ACTIVATION OF ADENOSINE A2A BUT NOT A2B RECEPTORS IS INVOLVED IN URIDINE ADENOSINE TETRAPHOSPHATE-MEDIATED CORONARY SMOOTH MUSCLE RELAXATION	215
Duroux R.	235
S12-01GUANOSINE-INDUCED NEUROPROTECTION: A ROLE FOR ADENOSINE RECEPTOR OLIGOMERS?	79
Dutar P.	235
P.62BENEFICIAL EFFECTS OF P2X7R DEFICIENCY IN A MOUSE MODEL OF TAUOPATHY	188
Eberini I.	235
P.47PHYSICAL AND FUNCTIONAL INTERACTION BETWEEN GPR17 AND THE CHEMOKINE RECEPTOR 2: A PROMISING TOOL FOR MANAGING REMYELINATION	173
Eddarkaoui S.	235
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Egea J.	235
P.16DESIGN, SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF NOVEL P2X7R ANTAGONISTS POTENTIALLY TARGETING THE CNS	142
El-Naggar H.	235
P.67BLOOD PURINE CONCENTRATION AS A NOVEL DIAGNOSTIC FOR SEIZURES AND EPILEPSY	193
Eltzschig H.	235
S7-01ADENOSINE AT THE CROSS-ROADS OF LUNG FIBROSIS AND PULMONARY HYPERTENSION	54
Engel T.	235
Simposium 14: P2X7: A COMMON TARGET FOR BRAIN DISEASES?	88
S14-01TARGETING OF ATP-GATED P2 RECEPTORS AS NOVEL TREATMENT FOR DRUG-REFRACTORY EPILEPSY	89
S14-02BAC TRANSGENIC MOUSE MODELS TO STUDY P2X7 EXPRESSION AND INTERACTIONS	90
P.32COMPARISON OF P2X7 PROTEIN EXPRESSION IN TWO BAC-TRANSGENIC REPORTER MOUSE MODELS	158
P.33IDENTIFICATION OF P2X7-DEPENDENT TRANSCRIPTOME AFTER SEIZURES	159
P.35THE CONTRIBUTION OF THE P2X7R TO DRUG REFRACTORY STATUS EPILEPTICUS	161
P.37THE P2X7 RECEPTOR’S CONTRIBUTION TO NEONATAL SEIZURES AND THE DEVELOPMENT OF CHRONIC EPILEPSY AND NEURO-COGNITIVE DEFICITS.	163
P.38CONTROL OF THE BLOOD-BRAIN BARRIER INTEGRITY DURING SEIZURES VIA THE ATP-GATED P2X7 RECEPTOR	164
P.40CONTEXT-SPECIFIC SWITCH FROM ANTI- TO PRO-EPILEPTOGENIC FUNCTION OF THE P2Y1 RECEPTOR IN EXPERIMENTAL EPILEPSY	166
P.50A POSSIBLE IMPLICATION OF THE ATP-GATED P2X7 RECEPTOR ON STATUS EPILEPTICUS-INDUCED ABERRANT NEUROGENESIS	176
P.67BLOOD PURINE CONCENTRATION AS A NOVEL DIAGNOSTIC FOR SEIZURES AND EPILEPSY	193
Engelowski E.	235
P9. PURINERGIC SIGNALING IN THE CARDIOVASCULAR SYSTEMP.86REGULATION OF IL-6 FORMATION IN THE HEART BY CD73-DERIVED ADENOSINE	212
Esplugues J.	235
S2-05DRUG-INDUCED CARDIOVASCULAR TOXICITY MEDIATED BY P2X7 RECEPTORS: THE EXAMPLE OF ABACAVIR	33
Evans R.	235
P.05UNCOVERING ‘HIDDEN’ CONFORMATIONS OF ATP-GATED P2X RECEPTORS USING BIOCHEMICAL AND BIOINFORMATICS METHODS	131
Fabbretti E.	235
S1-02THE ASIC3/P2X3 COGNATE RECEPTOR SENSES ACIDIC AND PURINERGIC PAIN IN A NOVEL MANNER	25
Fabbrizio P.	235
S20-04TARGETING P2X7 IN AMYOTROPHIC LATERAL SCLEROSIS: WHERE AND WHEN?	123
Failli P.	235
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
Faivre E.	235
P.63NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES MEMORY DEFICITS IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE.	189
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Falzoni S.	235
P.60MITOCHONDRIA ARE A KEY TARGET OF AMYLOID β-DEPENDENT DAMAGE IN MOUSE MICROGLIAL CELLS: ROLE OF THE P2X7 RECEPTOR AND PROTECTION BY NIMODIPINE.	186
Fernández V.	235
S12-01GUANOSINE-INDUCED NEUROPROTECTION: A ROLE FOR ADENOSINE RECEPTOR OLIGOMERS?	79
Ferraro L.	235
S9-03ADENOSINE HETERORECEPTOR COMPLEXES IN THE BASAL GANGLIA ARE IMPLICATED IN PARKINSON DISEASE AND ITS TREATMENT	66
Ferreira F.	235
S15-01ADENOSINE A2A RECEPTORS AND BDNF: AN INTIMATE INTERACTION REGULATING POSTNATAL HIPPOCAMPAL NEUROGENESIS	94
P.103POSTNATAL SUBVENTRICULAR ZONE NEUROGENESIS: ADENOSINE A2A RECEPTORS AS REGULATORS OF BRAIN-DERIVED NEUROTROPHIC FACTOR	229
Ferreira S.	235
S3-03ATP-DERIVED ADENOSINE CONTROLS SYNAPTIC AND MEMORY DYSFUNCTION IN β-AMYLOID MODELS OF ALZHEIMER’S DISEASE	37
S15-02CORTICAL NEURONAL MIGRATION ENTAILS A2A RECEPTOR-DRIVEN NEURONAL POLARIZATION AND AXON FORMATION	95
Ferreirinha F.	235
P.93ADENOSINE A2A RECEPTOR ACTIVATION PROMOTES FIBROSIS BY FAVORING PANNEXIN-1 OVEREXPRESSION IN HUMAN SUBCUTANEOUS FIBROBLASTS	219
P.95β3-ADRENOCEPTOR COUPLING TO EPAC1 AND PKC PROMOTES ADENOSINE RELEASE VIA ENT1 LEADING TO INHIBITION OF CHOLINERGIC NEUROTRANSMISSION IN THE HUMAN BLADDER	221
Ferreiro C.	235
P.58ADENOSINE A2A RECEPTOR ANTAGONISTS POTENTIATE CANNABINOID SIGNALING IN MICROGLIA	184
Ferrer A.	235
S1-01OVEREXPRESSION OF P2X3 AND P2X7 RECEPTORS AND TRPV1 CHANNELS IN ADRENOMEDULLARY CHROMAFFIN CELLS IN A RAT MODEL OF NEUROPATHIC PAIN	24
Fiedler W.	235
P7. PURINERGIC SIGNALING IN THE TUMORGROWTH ANDMETASTASISP.68CHARACTIZATION OF CD39 EXPRESSION ON T CELLS IN ACUTE MYELOID LEUKEMIA	194
Filipello F.	235
P.55MICROGLIA VERSUS MACROPHAGE EFFECTS ON OLIGODENDROCYTE PRECURSOR CELLS: ROLE OF EXTRACELLULAR VESICLES	181
Fischer B.	235
Simposium 18: MEDICINAL CHEMISTRY OF PURINE TARGETS	109
S18-01A QUEST FOR A DISEASE MODIFYING DRUG FOR THE TREATMENT OF OSTEOARTHRITIS-RELATED CALCIUM PYROPHOSPHATE DEPOSITION DISEASE	110
P.07DEVELOPMENT OF NPP1 INHIBITORS AS POTENTIAL DRUGS FOR THE TREATMENT OF OSTEOARTHRITIS/CPPD DISEASE	133
Fliegert R.	235
P4. ECTONUCLEOTIDASESP.18T CELL-DERIVED EXOSOMAL CD73 MEDIATES IMMUNE SUPPRESSION	144
Fontaine B.	235
P.62BENEFICIAL EFFECTS OF P2X7R DEFICIENCY IN A MOUSE MODEL OF TAUOPATHY	188
Fornai M.	235
P8. PURINERGIC SIGNALING IN IMMUNOLOGY AND INFLAMMATIONP.74THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF AR170, A POTENT AND SELECTIVE A3 RECEPTOR AGONIST, IN A RAT MODEL OF COLITIS	200
P.97ADENOSINE A2B RECEPTORS ON ENTERIC GLIA MEDIATE COLONIC DYSMOTILITY ASSOCIATED WITH HIGH FAT DIET-INDUCED OBESITY	223
Fournier I.	235
P.63NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES MEMORY DEFICITS IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE.	189
Fragoso M.	235
S7-04EXTRACELLULAR ATP REGULATES ANGIOGENIC RESPONSES IN VASA VASORUM ENDOTHELIAL CELLS VIA THE ACTIVATION OF PI3K-AKT-mTOR SIGNALING AXIS AND C-JUN, FOXO3A, AND C-MYC TRANSCRIPTION FACTORS	57
Franco R.	235
Simposium 9: ADENOSINE-RECEPTOR CONTAINING COMPLEXES. FROM MOLECULAR DYNAMICS AND PHARMACOLOGY TO METABOLISM	63
S9-02ROLE OF ADENOSINE IN METABOLISM	65
S9-03ADENOSINE HETERORECEPTOR COMPLEXES IN THE BASAL GANGLIA ARE IMPLICATED IN PARKINSON DISEASE AND ITS TREATMENT	66
S9-04ADENOSINE A2A RECEPTOR ACTIVATION ATTENUATE NMDA RECEPTOR FUNCTION IN ALZHEIMER DISEASE	67
P.58ADENOSINE A2A RECEPTOR ANTAGONISTS POTENTIATE CANNABINOID SIGNALING IN MICROGLIA	184
P11. PURINERGIC SIGNALING INOTHER FUNCTIONSP.101HETERODIMERIZATION OF ADENOSINE RECEPTORS IN BROWN ADIPOSE TISSUE	227
Freire M.	235
P.11A2B ANTAGONIST AS ANTIMETASTATIC AGENTS: DESIGN, SYNTHESIS AND OPTIMIZATION OF NOVEL CHEMOTYPES	137
Freitas R.	235
P10. PURINERGIC SIGNALING IN RENAL, GASTROINTESTINAL AND MUSCULOSKELETAL SYSTEMP.92ADP-INDUCED P2Y1-MEDIATED OSTEOGENESIS IS DOWNREGULATED BY OVEREXPRESSED P2Y12 AND P2Y13 RECEPTORS IN POSTMENOPAUSAL MESENCHYMAL STEM CELLS	218
Fromont G.	235
S10-01THE ROLE OF THE P2X4 RECEPTOR IN BREAST CANCER	69
Fuchs C	235
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING.	213
Fuhrmann M.	235
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
Fumagalli M.	235
S16-01EFFECTS OF ATP-INDUCED MICROGLIAL EXTRACELLULAR VESICLES ON OLIGODENDROCYTE PROGENITORS IN CEREBRAL ISCHEMIA	99
S16-04ACTIVATED MICROGLIA REGULATE THE RESPONSE OF OLIGODENDROCYTE PROGENITORS EXPRESSING THE P2Y-LIKE RECEPTOR GPR17 FOLLOWING CEREBRAL ISCHEMIA	102
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
P.55MICROGLIA VERSUS MACROPHAGE EFFECTS ON OLIGODENDROCYTE PRECURSOR CELLS: ROLE OF EXTRACELLULAR VESICLES	181
Fusco I.	235
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
S16-05THE SELECTIVE STIMULATION OF ADENOSINE A3 RECEPTOR INHIBITS N-TYPE CA2+ CURRENTS IN RAT DORSAL ROOT GANGLION NEURONS	103
P.57ADENOSINE A2B RECEPTORS AND SPHINGOSINE KINASE/SPHINGOSINE 1-PHOSPHATE SIGNALING AXIS CONTROL MATURATION OF OLIGODENDROCYTE PRECURSOR CELLS IN VITRO	183
Fuxe K.	235
Simposium 9: ADENOSINE-RECEPTOR CONTAINING COMPLEXES. FROM MOLECULAR DYNAMICS AND PHARMACOLOGY TO METABOLISM	63
S9-03ADENOSINE HETERORECEPTOR COMPLEXES IN THE BASAL GANGLIA ARE IMPLICATED IN PARKINSON DISEASE AND ITS TREATMENT	66
P.58ADENOSINE A2A RECEPTOR ANTAGONISTS POTENTIATE CANNABINOID SIGNALING IN MICROGLIA	184
Gabrielli M.	235
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
P.55MICROGLIA VERSUS MACROPHAGE EFFECTS ON OLIGODENDROCYTE PRECURSOR CELLS: ROLE OF EXTRACELLULAR VESICLES	181
Gampe K.	235
P.64THE ADP RECEPTOR P2Y13 IS SELECTIVELY EXPRESSED IN BRAIN MICROGLIA AND CONSTITUTIVELY ATTENUATES HIPPOCAMPAL NEUROGENESIS	190
García A.	235
P.16DESIGN, SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF NOVEL P2X7R ANTAGONISTS POTENTIALLY TARGETING THE CNS	142
P.48P2X7 RECEPTOR ANTAGONISM WITH JNJ-47965567 REDUCED BODY WEIGHT LOSS AND DELAYED DISEASE ONSET IN FEMALE AMYOTROPHIC LATERAL SCLEROSIS SOD1G93A MICE	174
García C.	235
P.11A2B ANTAGONIST AS ANTIMETASTATIC AGENTS: DESIGN, SYNTHESIS AND OPTIMIZATION OF NOVEL CHEMOTYPES	137
Garcia de Paco E	235
S3-01INVOLVEMENT OF PURINERGIC P2X4 RECEPTORS IN ALZHEIMER DISEASE	35
García E.	235
P.16DESIGN, SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF NOVEL P2X7R ANTAGONISTS POTENTIALLY TARGETING THE CNS	142
Garcia Gil M.	235
S12-03IMPACT OF IMP-GMP SPECIFIC 5'-NUCLEOTIDASE ON METABOLIC REGULATION AND DRUG RESISTANCE IN TUMORS	81
García J.	235
P.88POLYPHENOLS INCREASE ATP RELEASE AND NO PRODUCTION BY SEPARATE MECHANISMS IN MESENTERIC ENDOTHELIAL CELL CULTURES.	214
García M.	235
S2-02CROSSROAD BETWEEN BIOACTIVE LIPIDS AND PURINERGIC SIGNALLING IN MACROPHAGES	30
García X.	235
P.11A2B ANTAGONIST AS ANTIMETASTATIC AGENTS: DESIGN, SYNTHESIS AND OPTIMIZATION OF NOVEL CHEMOTYPES	137
Garlanda C.	235
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
Gaspar R.	235
P.76ADENOSINE A2A RECEPTOR MODULATION OF MICROGLIA MORPHOLOGIC REMODELLING IN EARLY NEURODEVELOPMENT - GENDER BIAS IN PHYSIOLOGY AND PSYCHIATRIC DISORDERS	202
Gaviano L.	235
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
P.57ADENOSINE A2B RECEPTORS AND SPHINGOSINE KINASE/SPHINGOSINE 1-PHOSPHATE SIGNALING AXIS CONTROL MATURATION OF OLIGODENDROCYTE PRECURSOR CELLS IN VITRO	183
P.65PROTECTIVE EFFECT OF THE ADENOSINE A2B RECEPTOR AGONIST, BAY60-6583, IN A RAT MODEL OF TRANSIENT CEREBRAL ISCHEMIA.	191
Gejo J.	235
S19-04P2X4 RECEPTOR CONTROLS MICROGLIA ACTIVATION AND FAVOURS REMYELINATION IN AUTOIMMUNE ENCEPHALITIS	118
Gelosa P.	235
S16-01EFFECTS OF ATP-INDUCED MICROGLIAL EXTRACELLULAR VESICLES ON OLIGODENDROCYTE PROGENITORS IN CEREBRAL ISCHEMIA	99
S16-04ACTIVATED MICROGLIA REGULATE THE RESPONSE OF OLIGODENDROCYTE PROGENITORS EXPRESSING THE P2Y-LIKE RECEPTOR GPR17 FOLLOWING CEREBRAL ISCHEMIA	102
Gendron F.	235
S18-01A QUEST FOR A DISEASE MODIFYING DRUG FOR THE TREATMENT OF OSTEOARTHRITIS-RELATED CALCIUM PYROPHOSPHATE DEPOSITION DISEASE	110
Georges F.	235
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Gerasimovskaya E.	235
Simposium 7: PURINES AND PURINERGIC RECEPTORS IN VASCULAR INJURY, CANCER, AND INFLAMMATION	53
S7-04EXTRACELLULAR ATP REGULATES ANGIOGENIC RESPONSES IN VASA VASORUM ENDOTHELIAL CELLS VIA THE ACTIVATION OF PI3K-AKT-mTOR SIGNALING AXIS AND C-JUN, FOXO3A, AND C-MYC TRANSCRIPTION FACTORS	57
Ghelardini C.	235
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
P8. PURINERGIC SIGNALING IN IMMUNOLOGY AND INFLAMMATIONP.74THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF AR170, A POTENT AND SELECTIVE A3 RECEPTOR AGONIST, IN A RAT MODEL OF COLITIS	200
Giacomelli C.	235
P.70EXTRACELLULAR ADENOSINE PROMOTES GLIOBLASTOMA INVASIVENESS THROUGH THE MODULATION OF MESENCHYMAL STEM CELL SECRETOME	196
Gil J.	235
S2-04CROSS-TALK BETWEEN P2 RECEPTORS AND TYROSINE KINASE RECEPTORS IN CEREBELLAR ASTROCYTES	32
P5. VESICULAR AND MEMBRANE TRANSPORTERSP.28ANALYSIS OF THE EXPRESION AND FUNCTION OF VNUT IN POSTNATAL CEREBELLUM	154
P.53P2X7 RECEPTOR REGULATES THE INDUCIBLE NUCLEAR DUAL-SPECIFICITY PHOSPHATASE 1 IN RAT CEREBELLAR ASTROCYTES	179
P.59P2X7 AND BDNF RECEPTORS CONVERGE TO SHAPE ERK SIGNALLING IN NEURONS THROUGH THE MODULATION OF ERK-DIRECTED PROTEIN PHOSPHATASES	185
Giovannini M.	235
P.65PROTECTIVE EFFECT OF THE ADENOSINE A2B RECEPTOR AGONIST, BAY60-6583, IN A RAT MODEL OF TRANSIENT CEREBRAL ISCHEMIA.	191
Giron M.	235
P.97ADENOSINE A2B RECEPTORS ON ENTERIC GLIA MEDIATE COLONIC DYSMOTILITY ASSOCIATED WITH HIGH FAT DIET-INDUCED OBESITY	223
Giuliani A.	235
P.60MITOCHONDRIA ARE A KEY TARGET OF AMYLOID β-DEPENDENT DAMAGE IN MOUSE MICROGLIAL CELLS: ROLE OF THE P2X7 RECEPTOR AND PROTECTION BY NIMODIPINE.	186
P.80INVESTIGATION ON THE ROLE OF THE P2X7R-NLRP3-IL-1β AXIS IN THE PATHOGENESIS OF HIDRADENITIS SUPPURATIVA	206
P.85THE P2X7 RECEPTOR IS SHED INTO CIRCULATION AND CORRELATES WITH C-REACTIVE PROTEIN LEVELS	211
Giuliani P.	235
S4-01INFLUENCE OF DIFFERENT PURINE RECEPTORS ON THE DIFFERENTIATION POTENTIAL OR MALIGNANCY OF NORMAL OR CANCEROUS MESENCHYMAL STEM CELLS, RESPECTIVELY	40
S12-04CONFLICTING EFFECTS OF GUANOSINE, GUANINE AND THEIR METABOLIZING ENZYMES ON NEUROPROTECTION AND TUMOR CELL PROLIFERATION	82
P.02P2X7 RECEPTOR ACTIVATION INCREASESMESENCHYMAL TRANSDIFFERENTIATION AND INVASIVENESS OF GLIOBLASTOMA-DERIVED STEM-LIKE CELLS	128
P.15P2X7 RECEPTOR MODULATES THE OSTEOGENIC DIFFERENTIATION OF STROMAL STEM CELLS FROM HUMAN ADIPOSE TISSUE	141
P.42INVESTIGATING THE ROLE OF GUANOSINE IN HUMAN NEUROBLASTOMA CELL DIFFERENTIATION.	168
Giussani P.	235
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
Gnad T.	235
S9-02ROLE OF ADENOSINE IN METABOLISM	65
P11. PURINERGIC SIGNALING INOTHER FUNCTIONSP.101HETERODIMERIZATION OF ADENOSINE RECEPTORS IN BROWN ADIPOSE TISSUE	227
Gölöncsér F.	236
S8-02MODULATION OF P2X7 RECEPTOR ACTIVITY BY EXTRACELLULAR ZN2+: IMPLICATIONS FOR MOOD DISORDERS	60
P.49CONTRIBUTION OF P2Y12 RECEPTORS TO ANIMAL MODEL OF NTG-INDUCED MIGRAINE-ASSOCIATED PAIN	175
Gomes C.	236
S15-03Catarina Gomes (ICBR, Coimbra, Portugal) Adenosine A2A receptor modulation of microglia morphologic remodeling in early neurodevelopment - gender bias in physiology and psychiatric disorders.	96
P.76ADENOSINE A2A RECEPTOR MODULATION OF MICROGLIA MORPHOLOGIC REMODELLING IN EARLY NEURODEVELOPMENT - GENDER BIAS IN PHYSIOLOGY AND PSYCHIATRIC DISORDERS	202
Gomes J.	236
S16-03ROLE OF ASTROCYTIC ADENOSINE ON THE MODULATION OF SYNAPTIC PLASTICITY BY BDNF	101
Gomes R.	236
P.36ADENOSINERGIC SYSTEM: NOVEL THERAPEUTIC TARGET FOR RETT SYNDROME	162
Gomez R.	236
S5-03LIVE IMAGING AND SINGLE CELL TRACKING REVEALS CELL DYNAMICS FROM EARLY CEREBELLAR NEURAL STEM CELLS. ROLE OF VNUT IN THEIR LINEAGE PROGRESSION.	47
Simposium 10: PURINERGIC RECEPTORS AND CANCER	68
S10-04REGULATION OF P2X7 RECEPTOR GENE EXPRESSION IN NEUROBLASTOMA CELLS	72
P.25ECTO-NUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE (E-NPP) ACTIVITY IN NEURO-2A NEUROBLASTOMA CELLS	151
P6. PURINERGIC SIGNALING IN NERVOUS SYSTEMP.29ANATOMIC STUDY OF THE CENTRAL NERVOUS SYSTEM DEVELOPMENT EMPLOYING THE MOUSE STRAIN P2rx7-EGFP.	155
P.46AGE-RELATED NUCLEAR TRANSLOCATION OF P2X6 SUBUNIT MODIFIES SPLICING ACTIVITY INTERACTING WITH SPLICING FACTOR 3A1	172
P.59P2X7 AND BDNF RECEPTORS CONVERGE TO SHAPE ERK SIGNALLING IN NEURONS THROUGH THE MODULATION OF ERK-DIRECTED PROTEIN PHOSPHATASES	185
P.71INHIBITION OF DUAL-SPECIFICITY PHOSPHATASES PROMOTES P2X7 RECEPTOR EXPRESSION IN NEUROBLASTOMA CELLS IN A p38-DEPENDENT MANNER	197
Gomez V.	236
P.63NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES MEMORY DEFICITS IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE.	189
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Gonçalves F.	236
S3-03ATP-DERIVED ADENOSINE CONTROLS SYNAPTIC AND MEMORY DYSFUNCTION IN β-AMYLOID MODELS OF ALZHEIMER’S DISEASE	37
P.10PHARMACOLOGICAL BLOCKADE OF ADENOSINE A2A RECEPTORS RECOVERS MOTOR LEARNING AND GRIP STRENGTH DEFICITS IN AN ANGELMAN SYNDROME MOUSE MODEL	136
Gonçalves M.	236
P.31INHIBITION OF THE DOPAMINE TRANSPORTER AS AN ANIMAL MODEL OF MANIA MODULATES ADENOSINE RECEPTORS AND INFLAMMATORY RESPONSES IN THE BRAIN	157
Gonçalves N.	236
S3-03ATP-DERIVED ADENOSINE CONTROLS SYNAPTIC AND MEMORY DYSFUNCTION IN β-AMYLOID MODELS OF ALZHEIMER’S DISEASE	37
S15-02CORTICAL NEURONAL MIGRATION ENTAILS A2A RECEPTOR-DRIVEN NEURONAL POLARIZATION AND AXON FORMATION	95
P.54ROLE OF ASTROCYTIC ADENOSINE A2A RECEPTORS IN THE FACILITATION OF SYNAPTIC PLASTICITY IN CORTICO-STRIATAL SYNAPSES	180
Gonçalves T.	236
P.19EXTRACELLULAR NUCLEOTIDE METABOLISM IN THE CONTEXT OF YEAST-HOST INTERACTION	145
P.102SIGNIFICANCE OF ADENOSINE A2A RECEPTORS IN THE COMMENSAL-PATHOGEN SWITCH IN THE ELDERLY GUT	228
Gratal P.	236
P.100TENOFOVIR CAUSES BONE LOSS VIA DECREASED BONE FORMATION AND INCREASED BONE RESORPTION, WHICH CAN BE COUNTERACTED BY ADENOSINE A2A RECEPTOR IN MICE	226
Grillari J.	236
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING.	213
Grutter T.	236
S8-01PERMEATION MECHANISMS OF LARGE CATIONS IN ATP-GATED P2X RECEPTORS	59
Grygorczyk R.	236
S17-01ATP RELEASE FROM MAST CELLS BY ACUPUNCTURE STIMULI	105
Gu B.	236
S19-03THE P2X7 RECEPTOR HAS A SCAVENGER ROLE IN THE CENTRAL NERVOUS SYSTEM WHICH IS LITTLE AFFECTED BY ANTAGONISTS OF P2X7 PORE FUNCTION	117
Gualerzi A.	236
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
Gualix J.	236
S1-01OVEREXPRESSION OF P2X3 AND P2X7 RECEPTORS AND TRPV1 CHANNELS IN ADRENOMEDULLARY CHROMAFFIN CELLS IN A RAT MODEL OF NEUROPATHIC PAIN	24
P.25ECTO-NUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE (E-NPP) ACTIVITY IN NEURO-2A NEUROBLASTOMA CELLS	151
P.71INHIBITION OF DUAL-SPECIFICITY PHOSPHATASES PROMOTES P2X7 RECEPTOR EXPRESSION IN NEUROBLASTOMA CELLS IN A p38-DEPENDENT MANNER	197
Guibon R.	236
S10-01THE ROLE OF THE P2X4 RECEPTOR IN BREAST CANCER	69
Guixà R.	236
S2-03ADENOSINE RECEPTORS AS A PRIMARY TARGET FOR RESVERATROL: FROM ANTITUMORAL TO NEUROPROTECTION ACTION	31
Guse A.	236
P.79COLLABORATIVE RESEARCH CENTER SFB 1328: ADENINE NUCLEOTIDES IN IMMUNITY AND INFLAMMATION	205
Gutiérrez de Terán H	236
S18-02INTEGRATED APPROACHES TO MODEL THE CONFORMATIONAL EQUILIBRIUM AND THE LIGAND OPTIMIZATION ON ADENOSINE RECEPTORS	111
P.11A2B ANTAGONIST AS ANTIMETASTATIC AGENTS: DESIGN, SYNTHESIS AND OPTIMIZATION OF NOVEL CHEMOTYPES	137
Haag F.	236
P3. PHARMACOLOGY AND BIOCHEMISTRY OF P2 RECEPTORSP.14FLUORESCENT SENSORS FOR THE IMAGING OF ATP AT CELL SURFACES	140
P7. PURINERGIC SIGNALING IN THE TUMORGROWTH ANDMETASTASISP.68CHARACTIZATION OF CD39 EXPRESSION ON T CELLS IN ACUTE MYELOID LEUKEMIA	194
P.77INTERACTION OF P2X7 WITH THE ER STRESS/UNFOLDED PROTEIN RESPONSE PATHWAYS	203
Halle A.	236
Simposium 3: PURINERGIC RECEPTORS AS FUTURE TARGETS IN ALZHEIMER’S DISEASE?	34
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
S3-04PURINERGIC SIGNALING SHAPES MICROGLIAL FUNCTIONS IN ALZHEIMER’S DISEASE	38
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Hamdane M.	236
P.63NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES MEMORY DEFICITS IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE.	189
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Hansen J.	236
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
S3-04PURINERGIC SIGNALING SHAPES MICROGLIAL FUNCTIONS IN ALZHEIMER’S DISEASE	38
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS	192
Harms T.	236
P.12DEVELOPMENT OF A LIVE CELL NANOBRET BINDING ASSAY FOR ADENOSINE A2B RECEPTORS	138
Harter P.	236
P.20P.A METABOLIC IMMUNE CHECKPOINT: ADENOSINE IN BRAIN METASTASES TUMOR MICROENVIRONMENT	146
Haufs S.	236
P.104ROLE OF ADENOSINE IN ADIPOSE TISSUE FIBROSIS	230
Hausmann R.	236
Simposium 11: STRUCTURAL INSIGHTS INTO LIGAND BINDING AND DYNAMICS OF P2X RECEPTORS	73
S11-02THE MOLECULAR DYNAMICS OF ION CONDUCTION IN P2X RECEPTORS	75
Hector J.	236
S6-03IN-SITU CROSS-LINKING OF P2X7 COMPLEXES TO IDENTIFY PROTEIN-PROTEIN INTERACTIONS	51
S14-02BAC TRANSGENIC MOUSE MODELS TO STUDY P2X7 EXPRESSION AND INTERACTIONS	90
Heisig F.	236
P.12DEVELOPMENT OF A LIVE CELL NANOBRET BINDING ASSAY FOR ADENOSINE A2B RECEPTORS	138
Heitman L.	236
P.13SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 3’-DEOXY-(N)-METHANOCARBA-BASED ADENOSINE RECEPTOR LIGANDS	139
Hemshall D.	236
P.67BLOOD PURINE CONCENTRATION AS A NOVEL DIAGNOSTIC FOR SEIZURES AND EPILEPSY	193
Henneberger C.	236
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
Henriques C.	236
P.76ADENOSINE A2A RECEPTOR MODULATION OF MICROGLIA MORPHOLOGIC REMODELLING IN EARLY NEURODEVELOPMENT - GENDER BIAS IN PHYSIOLOGY AND PSYCHIATRIC DISORDERS	202
Henseler A.	236
P9. PURINERGIC SIGNALING IN THE CARDIOVASCULAR SYSTEMP.86REGULATION OF IL-6 FORMATION IN THE HEART BY CD73-DERIVED ADENOSINE	212
P.91IMPACT OF CD73-DERIVED ADENOSINE ON THE CELL-TYPE SPECIFIC CYTOKINE RESPONSE IN THE INFARCTED MURINE HEART	217
Henshall D.	236
P.37THE P2X7 RECEPTOR’S CONTRIBUTION TO NEONATAL SEIZURES AND THE DEVELOPMENT OF CHRONIC EPILEPSY AND NEURO-COGNITIVE DEFICITS.	163
P.40CONTEXT-SPECIFIC SWITCH FROM ANTI- TO PRO-EPILEPTOGENIC FUNCTION OF THE P2Y1 RECEPTOR IN EXPERIMENTAL EPILEPSY	166
Heredero H.	236
S10-03ROLE OF PURINERGIC SIGNALIN IN PANCREATIC CANCER	71
Herman de Sousa C.	236
P.93ADENOSINE A2A RECEPTOR ACTIVATION PROMOTES FIBROSIS BY FAVORING PANNEXIN-1 OVEREXPRESSION IN HUMAN SUBCUTANEOUS FIBROBLASTS	219
Herrero G.	236
P.100TENOFOVIR CAUSES BONE LOSS VIA DECREASED BONE FORMATION AND INCREASED BONE RESORPTION, WHICH CAN BE COUNTERACTED BY ADENOSINE A2A RECEPTOR IN MICE	226
Hesse J.	236
P.26MONO-ADP-RIBOSYLATION OF CD73 – A NEW LEVEL OF PURI-NERGIC CONTROL	152
P.90PURINE METABOLISM IN CARDIAC FIBROBLASTS AND EPICARDIUM-DERIVED CELLS, SIMULTANEOUSLY ISOLATED FROM THE INFARCTED MOUSE HEART	216
Hinz S.	236
P.12DEVELOPMENT OF A LIVE CELL NANOBRET BINDING ASSAY FOR ADENOSINE A2B RECEPTORS	138
Hockemeyer J.	236
P.12DEVELOPMENT OF A LIVE CELL NANOBRET BINDING ASSAY FOR ADENOSINE A2B RECEPTORS	138
Hoffmann C.	236
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING.	213
Holger S.	236
P.23DEVELOPMENT OF A HIGH-THROUGHPUT SCREENING ASSAY FOR THE IDENTIFICATION AND CHARACTERIZATION OF NUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE 4 (NPP4) INHIBITORS	149
Holnthoner W.	236
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING.	213
Hu W.	236
S17-03PURINERGIC SIGNALING IN INFLAMMATORY BOWEL DISEASE AND IT’S ROLE IN THE EFFECT OF ACUPUNCTURE AND MOXIBUSTION	107
Hua J.	236
S3-01INVOLVEMENT OF PURINERGIC P2X4 RECEPTORS IN ALZHEIMER DISEASE	35
Huang L.	236
S1-02THE ASIC3/P2X3 COGNATE RECEPTOR SENSES ACIDIC AND PURINERGIC PAIN IN A NOVEL MANNER	25
S8-02MODULATION OF P2X7 RECEPTOR ACTIVITY BY EXTRACELLULAR ZN2+: IMPLICATIONS FOR MOOD DISORDERS	60
P.43INVOLVEMENT OF P2X7RS IN EXCITATORY NEUROTRANSMISSION IN THE MOUSE DENTATE GYRUS GRANULE CELLS	169
Huang M.	236
S17-01ATP RELEASE FROM MAST CELLS BY ACUPUNCTURE STIMULI	105
Huidobro J.	236
P.06ALFAXOLONE-INDUCED P2X4R ALLOSTERIC AGONISM CONFIRMED BY MOLECULAR DYNAMIC CALCULATIONS	132
Ialenti A.	236
P.81ROLE OF CD73 IN THE DEVELOPMENT OF MURINE ALLERGIC ASTHMA	207
Idzko M.	236
S20-05Marco Idzko (Division of Pulmonology, Department of Medicine II, Medical University of Vienna, Vienna, Austria)	124
Illes P.	236
Simposium 1: NOVEL INSIGHTS INTO P2X3 AND A3 RECEPTOR CONTRIBUTION TO PAIN STATES	23
S1-02THE ASIC3/P2X3 COGNATE RECEPTOR SENSES ACIDIC AND PURINERGIC PAIN IN A NOVEL MANNER	25
Imhof A.	236
S6-03IN-SITU CROSS-LINKING OF P2X7 COMPLEXES TO IDENTIFY PROTEIN-PROTEIN INTERACTIONS	51
Jacobson K.	236
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
S12-01GUANOSINE-INDUCED NEUROPROTECTION: A ROLE FOR ADENOSINE RECEPTOR OLIGOMERS?	79
S16-05THE SELECTIVE STIMULATION OF ADENOSINE A3 RECEPTOR INHIBITS N-TYPE CA2+ CURRENTS IN RAT DORSAL ROOT GANGLION NEURONS	103
P.13SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 3’-DEOXY-(N)-METHANOCARBA-BASED ADENOSINE RECEPTOR LIGANDS	139
P.24URIDINE- AND CYTIDINE-BASED ECTO-5ꞌ-NUCLEOTIDASE-INHIBITORS: A NOVEL CLASS OF HIGHLY ACTIVE AND SELECTIVE CD73-INHIBITORS	150
Jaén R.	236
S2-02CROSSROAD BETWEEN BIOACTIVE LIPIDS AND PURINERGIC SIGNALLING IN MACROPHAGES	30
Jain S.	236
P.24URIDINE- AND CYTIDINE-BASED ECTO-5ꞌ-NUCLEOTIDASE-INHIBITORS: A NOVEL CLASS OF HIGHLY ACTIVE AND SELECTIVE CD73-INHIBITORS	150
Jalkanen S.	236
S12-02EXTRA- AND INTRACELLULAR METABOLISM OF ADENOSINE IN CANCER AND INFLAMMATION	80
Jaradat A.	236
P.03IDENTIFYING REGIONS OF P2X7 RECEPTOR INTRACELLULAR DOMAINS INVOLVED IN DOWNSTREAM SIGNALING	129
Javed S.	236
P.77INTERACTION OF P2X7 WITH THE ER STRESS/UNFOLDED PROTEIN RESPONSE PATHWAYS	203
Jesus J.	236
S16-03ROLE OF ASTROCYTIC ADENOSINE ON THE MODULATION OF SYNAPTIC PLASTICITY BY BDNF	101
Jiang L.H.	236
Simposium 4: HOW PURINERGIC SIGNALING INFLUENCES THE ACTIVITY OF HUMAN MESENCHYMAL STROMAL/STEM CELLS	39
S4-03ATP-INDUCED CALCIUM SIGNALLING IN MESENCHYMAL STEM CELL FUNCTIONS	42
Jiao T.	236
P.89THE ACTIVATION OF ADENOSINE A2A BUT NOT A2B RECEPTORS IS INVOLVED IN URIDINE ADENOSINE TETRAPHOSPHATE-MEDIATED CORONARY SMOOTH MUSCLE RELAXATION	215
Jiménez E.	236
S1-01OVEREXPRESSION OF P2X3 AND P2X7 RECEPTORS AND TRPV1 CHANNELS IN ADRENOMEDULLARY CHROMAFFIN CELLS IN A RAT MODEL OF NEUROPATHIC PAIN	24
S5-01MODULATION OF NEURONAL GLYCINE TRANSPORT BY P2Y AND P2X RECEPTORS	45
P.33IDENTIFICATION OF P2X7-DEPENDENT TRANSCRIPTOME AFTER SEIZURES	159
P.37THE P2X7 RECEPTOR’S CONTRIBUTION TO NEONATAL SEIZURES AND THE DEVELOPMENT OF CHRONIC EPILEPSY AND NEURO-COGNITIVE DEFICITS.	163
Jiménez J.	236
P.58ADENOSINE A2A RECEPTOR ANTAGONISTS POTENTIATE CANNABINOID SIGNALING IN MICROGLIA	184
Jindrichova M.	236
P1. STRUCTURE OF PURINE RECEPTORS AND ECTONUCLEOTIDASESP.01IDENTIFICATION OF P2X7 RECEPTOR EXTRACELLULAR VESTIBULE RESIDUES CONTRIBUTING TO RECEPTOR STRUCTURE AND CHANNEL GATING	127
Jordheim L.P.	236
S12-03IMPACT OF IMP-GMP SPECIFIC 5'-NUCLEOTIDASE ON METABOLIC REGULATION AND DRUG RESISTANCE IN TUMORS	81
Jovanovic S.	236
P.56PARACRINE SIGNALING VIA P2X2/3R IS REQUIRED FOR FUNCTIONAL DEVELOPMENT OF A CENTRAL AUDITORY SYNAPSE	182
Junger W.	236
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING.	213
Junker A.	236
S18-04Anna Junker (Germany) P2 receptor ligands, PET tracers	113
P.13SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 3’-DEOXY-(N)-METHANOCARBA-BASED ADENOSINE RECEPTOR LIGANDS	139
P.24URIDINE- AND CYTIDINE-BASED ECTO-5ꞌ-NUCLEOTIDASE-INHIBITORS: A NOVEL CLASS OF HIGHLY ACTIVE AND SELECTIVE CD73-INHIBITORS	150
Karmouty H.	236
S7-01ADENOSINE AT THE CROSS-ROADS OF LUNG FIBROSIS AND PULMONARY HYPERTENSION	54
Karoor V.	236
S7-04EXTRACELLULAR ATP REGULATES ANGIOGENIC RESPONSES IN VASA VASORUM ENDOTHELIAL CELLS VIA THE ACTIVATION OF PI3K-AKT-mTOR SIGNALING AXIS AND C-JUN, FOXO3A, AND C-MYC TRANSCRIPTION FACTORS	57
Kaschubowski K.	236
P3. PHARMACOLOGY AND BIOCHEMISTRY OF P2 RECEPTORSP.14FLUORESCENT SENSORS FOR THE IMAGING OF ATP AT CELL SURFACES	140
Kasper M.	236
P.105P2X7R INDIRECTLY REGULATES THE JAM-A PROTEIN CONTENT VIA MODULATION OF THE GSK-3β AND PKC-β1	231
Kazuhide I.	236
CPL-02PURINERGIC SIGNALING IN MICROGLIAL FUNCTIONS	17
Keller A.	236
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
Kennedy C.	236
P.17CHARACTERISATION OF P2Y2 RECEPTORS IN HUMAN VASCULAR ENDOTHELIAL CELLS USING AR-C118925XX, A POTENT AND SELECTIVE P2Y2 ANTAGONIST	143
Keppler K.	236
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
Kerlero de Rosbo N.	236
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
Klapperstück M.	236
P.08POINT MUTATIONS IN P2X7 RECEPTORS	134
P.84INTERACTION OF THE SPHINGOSINE-1-PHOSPHATE PATHWAY WITH PURINERGIC RECEPTORS	210
Kless A.	236
S8-04STRUCTURE-FUNCTION RELATIONSHIP OF P2X7 RECEPTORS	62
Koch F.	236
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
S6-04IMMUNE CELLS FROM P2X4KO MICE EXHIBIT ALTERED P2X7 EXPRESSION AND FUNCTION	52
P3. PHARMACOLOGY AND BIOCHEMISTRY OF P2 RECEPTORSP.14FLUORESCENT SENSORS FOR THE IMAGING OF ATP AT CELL SURFACES	140
P.77INTERACTION OF P2X7 WITH THE ER STRESS/UNFOLDED PROTEIN RESPONSE PATHWAYS	203
Kock M.	236
P.13SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 3’-DEOXY-(N)-METHANOCARBA-BASED ADENOSINE RECEPTOR LIGANDS	139
Köfalvi A.	236
P.39ADENOSINE-MEDIATED CONTROL OF SYNAPTIC AND BEHAVIOURAL ACTIONS OF CANNABINOIDS	165
Komarova S.	236
P.99ROLE OF UDP-GLUCOSE RECEPTOR P2Y14 IN OSTEOBLASTS	225
Kopp R.	236
S6-03IN-SITU CROSS-LINKING OF P2X7 COMPLEXES TO IDENTIFY PROTEIN-PROTEIN INTERACTIONS	51
S14-02BAC TRANSGENIC MOUSE MODELS TO STUDY P2X7 EXPRESSION AND INTERACTIONS	90
P.32COMPARISON OF P2X7 PROTEIN EXPRESSION IN TWO BAC-TRANSGENIC REPORTER MOUSE MODELS	158
Kovacs G.	236
S8-02MODULATION OF P2X7 RECEPTOR ACTIVITY BY EXTRACELLULAR ZN2+: IMPLICATIONS FOR MOOD DISORDERS	60
Kozlov S.	237
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS	192
Krüge U.	237
S17-02THE ROLE OF PURINE RECEPTOR IN THE TREATMENT OF DEPRESSION BY taVNS	106
Labuda K.	237
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING.	213
Lacey A.	237
P.67BLOOD PURINE CONCENTRATION AS A NOVEL DIAGNOSTIC FOR SEIZURES AND EPILEPSY	193
Lalo U.	237
S13-02ATP IN ASTROGLIAL CONTROL OF SYNAPTIC PLASTICITY IN AGEING AND AD	85
Lambertucci C.	237
S11-04STRUCTURAL INSIGHTS INTO MODIFICATIONS TO THE ATP MOLECULE TUNING ITS AGONIST-TO-ANTAGONIST ACTIVITY AT THE P2X RECEPTORS	77
P8. PURINERGIC SIGNALING IN IMMUNOLOGY AND INFLAMMATIONP.74THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF AR170, A POTENT AND SELECTIVE A3 RECEPTOR AGONIST, IN A RAT MODEL OF COLITIS	200
P.83NEW 4’-TETRAZOLYL ADENOSINE DERIVATIVES AS POTENTIAL AGENTS FOR WOUND HEALING	209
Lana D.	237
P.65PROTECTIVE EFFECT OF THE ADENOSINE A2B RECEPTOR AGONIST, BAY60-6583, IN A RAT MODEL OF TRANSIENT CEREBRAL ISCHEMIA.	191
Landrieu I.	237
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Lanznaster D.	237
S12-01GUANOSINE-INDUCED NEUROPROTECTION: A ROLE FOR ADENOSINE RECEPTOR OLIGOMERS?	79
Lapel M.	237
S7-04EXTRACELLULAR ATP REGULATES ANGIOGENIC RESPONSES IN VASA VASORUM ENDOTHELIAL CELLS VIA THE ACTIVATION OF PI3K-AKT-mTOR SIGNALING AXIS AND C-JUN, FOXO3A, AND C-MYC TRANSCRIPTION FACTORS	57
Largo R.	237
P.100TENOFOVIR CAUSES BONE LOSS VIA DECREASED BONE FORMATION AND INCREASED BONE RESORPTION, WHICH CAN BE COUNTERACTED BY ADENOSINE A2A RECEPTOR IN MICE	226
Larrañaga A.	237
P.96PANNEXIN1 KO MICE ARE IRRESPONSIVE TO TENOFOVIR INDUCED BONE LOSS	222
P.100TENOFOVIR CAUSES BONE LOSS VIA DECREASED BONE FORMATION AND INCREASED BONE RESORPTION, WHICH CAN BE COUNTERACTED BY ADENOSINE A2A RECEPTOR IN MICE	226
Latapiat V.	237
P.06ALFAXOLONE-INDUCED P2X4R ALLOSTERIC AGONISM CONFIRMED BY MOLECULAR DYNAMIC CALCULATIONS	132
Laubach A.	237
P3. PHARMACOLOGY AND BIOCHEMISTRY OF P2 RECEPTORSP.14FLUORESCENT SENSORS FOR THE IMAGING OF ATP AT CELL SURFACES	140
Le Gras S.	237
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Le Pape A.	237
S10-01THE ROLE OF THE P2X4 RECEPTOR IN BREAST CANCER	69
Lede V.	237
P.98RENAL PAPILLA EXPRESSES HIGH LEVELS OF THE UDP-GLUCOSE RECEPTOR P2RY14	224
Lee S.	237
S3-04PURINERGIC SIGNALING SHAPES MICROGLIAL FUNCTIONS IN ALZHEIMER’S DISEASE	38
P.07DEVELOPMENT OF NPP1 INHIBITORS AS POTENTIAL DRUGS FOR THE TREATMENT OF OSTEOARTHRITIS/CPPD DISEASE	133
Lee S.Y.	237
P.23DEVELOPMENT OF A HIGH-THROUGHPUT SCREENING ASSAY FOR THE IDENTIFICATION AND CHARACTERIZATION OF NUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE 4 (NPP4) INHIBITORS	149
P.27SYNTHESIS OF FLUORESCENCE-LABELED AMP AND ADENOSINE DERIVATIVES AS TOOLS FOR MONITORING CD73 ACTIVITY	153
Lemos C.	237
S3-03ATP-DERIVED ADENOSINE CONTROLS SYNAPTIC AND MEMORY DYSFUNCTION IN β-AMYLOID MODELS OF ALZHEIMER’S DISEASE	37
Lerondel S.	237
S10-01THE ROLE OF THE P2X4 RECEPTOR IN BREAST CANCER	69
Levi S.	237
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Simposium 15: KEY ROLES OF ADENOSINE A2A RECEPTORS THROUGHOUT BRAIN DEVELOPMENT	93
S15-04A2AR SIGNALLING REGULATES SYNAPTOGENESIS IN THE DEVELOPING BRAIN	97
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Li Sihui.	237
S17-03PURINERGIC SIGNALING IN INFLAMMATORY BOWEL DISEASE AND IT’S ROLE IN THE EFFECT OF ACUPUNCTURE AND MOXIBUSTION	107
Li Shaoyuan.	237
P.75P2X7R PLAY AN IMPORTANT ROLE IN ANTIDEPRESSANT EFFECT OF TAVNS	201
Lillo A.	237
S9-04ADENOSINE A2A RECEPTOR ACTIVATION ATTENUATE NMDA RECEPTOR FUNCTION IN ALZHEIMER DISEASE	67
P.58ADENOSINE A2A RECEPTOR ANTAGONISTS POTENTIATE CANNABINOID SIGNALING IN MICROGLIA	184
Limongelli V.	237
S9-01UNRAVELING THE GPCR DIMERIZATION BY SECOND TIMESCALE FREE-ENERGY CALCULATIONS	64
Liu R.	237
P.13SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 3’-DEOXY-(N)-METHANOCARBA-BASED ADENOSINE RECEPTOR LIGANDS	139
Liu Y.	237
P.75P2X7R PLAY AN IMPORTANT ROLE IN ANTIDEPRESSANT EFFECT OF TAVNS	201
Llamas P.	237
P.100TENOFOVIR CAUSES BONE LOSS VIA DECREASED BONE FORMATION AND INCREASED BONE RESORPTION, WHICH CAN BE COUNTERACTED BY ADENOSINE A2A RECEPTOR IN MICE	226
Lohr C.	237
P.79COLLABORATIVE RESEARCH CENTER SFB 1328: ADENINE NUCLEOTIDES IN IMMUNITY AND INFLAMMATION	205
Lombardi M.	237
S16-01EFFECTS OF ATP-INDUCED MICROGLIAL EXTRACELLULAR VESICLES ON OLIGODENDROCYTE PROGENITORS IN CEREBRAL ISCHEMIA	99
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
P.55MICROGLIA VERSUS MACROPHAGE EFFECTS ON OLIGODENDROCYTE PRECURSOR CELLS: ROLE OF EXTRACELLULAR VESICLES	181
Lopes A.	237
P.94URINARY ATP CONCENTRATION IS RELATED TO DETRUSOR PRESSURE DURING VOIDING	220
Lopes J.	237
S3-03ATP-DERIVED ADENOSINE CONTROLS SYNAPTIC AND MEMORY DYSFUNCTION IN β-AMYLOID MODELS OF ALZHEIMER’S DISEASE	37
P.10PHARMACOLOGICAL BLOCKADE OF ADENOSINE A2A RECEPTORS RECOVERS MOTOR LEARNING AND GRIP STRENGTH DEFICITS IN AN ANGELMAN SYNDROME MOUSE MODEL	136
Lopes L.	237
Simposium 21: TEACHING CAFFEINE NEW TRICKS FOR OLD PROBLEMS IN PARKINSON'S DISEASE	125
Lopes L.V.	237
P.36ADENOSINERGIC SYSTEM: NOVEL THERAPEUTIC TARGET FOR RETT SYNDROME	162
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Lopez B.	237
Simposium 5: MEMBRANE TRANSPORTERS AND PURINERGIC SIGNALLING	44
S5-01MODULATION OF NEURONAL GLYCINE TRANSPORT BY P2Y AND P2X RECEPTORS	45
Lopez G.	237
S15-02CORTICAL NEURONAL MIGRATION ENTAILS A2A RECEPTOR-DRIVEN NEURONAL POLARIZATION AND AXON FORMATION	95
Lopez V.	237
P.22INVESTIGATION OF HEPARIN-INDUCED ECTONUCLEOTIDASE-INHIBITION TO COUNTERACT ADENOSINE-MEDIATED IMMUNOSUPPRESSION IN THE TUMOR MICROENVIRONMENT	148
P.23DEVELOPMENT OF A HIGH-THROUGHPUT SCREENING ASSAY FOR THE IDENTIFICATION AND CHARACTERIZATION OF NUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE 4 (NPP4) INHIBITORS	149
Losenkova K.	237
S12-02EXTRA- AND INTRACELLULAR METABOLISM OF ADENOSINE IN CANCER AND INFLAMMATION	80
Loza M.	237
P2. PHARMACOLOGY AND BIOCHEMISTRY OF P1 RECEPTORSP.092-ARYLADENINE DERIVATIVES AS POTENT SCAFFOLDS FOR A1, A3 AND DUAL A1/A3 ADENOSINE RECEPTOR ANTAGONISTS: SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS	135
P.11A2B ANTAGONIST AS ANTIMETASTATIC AGENTS: DESIGN, SYNTHESIS AND OPTIMIZATION OF NOVEL CHEMOTYPES	137
Lucarini E.	237
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
P8. PURINERGIC SIGNALING IN IMMUNOLOGY AND INFLAMMATIONP.74THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF AR170, A POTENT AND SELECTIVE A3 RECEPTOR AGONIST, IN A RAT MODEL OF COLITIS	200
Lukowiak M.	237
S6-04IMMUNE CELLS FROM P2X4KO MICE EXHIBIT ALTERED P2X7 EXPRESSION AND FUNCTION	52
Lumei H.	237
S1-02THE ASIC3/P2X3 COGNATE RECEPTOR SENSES ACIDIC AND PURINERGIC PAIN IN A NOVEL MANNER	25
S8-02MODULATION OF P2X7 RECEPTOR ACTIVITY BY EXTRACELLULAR ZN2+: IMPLICATIONS FOR MOOD DISORDERS	60
P.43INVOLVEMENT OF P2X7RS IN EXCITATORY NEUROTRANSMISSION IN THE MOUSE DENTATE GYRUS GRANULE CELLS	169
Luo X.	237
P.07DEVELOPMENT OF NPP1 INHIBITORS AS POTENTIAL DRUGS FOR THE TREATMENT OF OSTEOARTHRITIS/CPPD DISEASE	133
Luongo L.	237
S1-04TARGETING ADENOSINE RECEPTORS TO TREAT NEUROPATHIC PAIN	27
Machtens J.	237
S11-02THE MOLECULAR DYNAMICS OF ION CONDUCTION IN P2X RECEPTORS	75
Madonna G.	237
P.21ANALYSIS OF CD73 IN SERUM OF CANCER PATIENTS AND HEALTHY DONORS	147
Magalhães M.	237
P.93ADENOSINE A2A RECEPTOR ACTIVATION PROMOTES FIBROSIS BY FAVORING PANNEXIN-1 OVEREXPRESSION IN HUMAN SUBCUTANEOUS FIBROBLASTS	219
P.95β3-ADRENOCEPTOR COUPLING TO EPAC1 AND PKC PROMOTES ADENOSINE RELEASE VIA ENT1 LEADING TO INHIBITION OF CHOLINERGIC NEUROTRANSMISSION IN THE HUMAN BLADDER	221
Magni L.	237
S10-03ROLE OF PURINERGIC SIGNALIN IN PANCREATIC CANCER	71
Magnus T.	237
S6-04IMMUNE CELLS FROM P2X4KO MICE EXHIBIT ALTERED P2X7 EXPRESSION AND FUNCTION	52
Majellaro M.	237
P.11A2B ANTAGONIST AS ANTIMETASTATIC AGENTS: DESIGN, SYNTHESIS AND OPTIMIZATION OF NOVEL CHEMOTYPES	137
Manfredini M.	237
P.80INVESTIGATION ON THE ROLE OF THE P2X7R-NLRP3-IL-1β AXIS IN THE PATHOGENESIS OF HIDRADENITIS SUPPURATIVA	206
Marco M.	237
P.78ADENOSINE A2B RECEPTOR ACTIVATION IMPROVES EPIDERMAL BARRIER INTEGRITY DAMPENED BY INFLAMMATION	204
P.82THERAPEUTIC POTENTIAL OF ADENOSINE IN INFLAMMATORY SKIN DISEASES	208
Mariggiò M.	237
P.15P2X7 RECEPTOR MODULATES THE OSTEOGENIC DIFFERENTIATION OF STROMAL STEM CELLS FROM HUMAN ADIPOSE TISSUE	141
Marín A.	237
P.78ADENOSINE A2B RECEPTOR ACTIVATION IMPROVES EPIDERMAL BARRIER INTEGRITY DAMPENED BY INFLAMMATION	204
P.82THERAPEUTIC POTENTIAL OF ADENOSINE IN INFLAMMATORY SKIN DISEASES	208
Marinhas J.	237
P10. PURINERGIC SIGNALING IN RENAL, GASTROINTESTINAL AND MUSCULOSKELETAL SYSTEMP.92ADP-INDUCED P2Y1-MEDIATED OSTEOGENESIS IS DOWNREGULATED BY OVEREXPRESSED P2Y12 AND P2Y13 RECEPTORS IN POSTMENOPAUSAL MESENCHYMAL STEM CELLS	218
Marková V.	237
S12-01GUANOSINE-INDUCED NEUROPROTECTION: A ROLE FOR ADENOSINE RECEPTOR OLIGOMERS?	79
Markwardt F.	237
S8-04STRUCTURE-FUNCTION RELATIONSHIP OF P2X7 RECEPTORS	62
P.08POINT MUTATIONS IN P2X7 RECEPTORS	134
P.84INTERACTION OF THE SPHINGOSINE-1-PHOSPHATE PATHWAY WITH PURINERGIC RECEPTORS	210
Marques J.M.	237
S15-02CORTICAL NEURONAL MIGRATION ENTAILS A2A RECEPTOR-DRIVEN NEURONAL POLARIZATION AND AXON FORMATION	95
Marques X.	237
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Martin A.	237
S19-04P2X4 RECEPTOR CONTROLS MICROGLIA ACTIVATION AND FAVOURS REMYELINATION IN AUTOIMMUNE ENCEPHALITIS	118
Martin E.	237
P.62BENEFICIAL EFFECTS OF P2X7R DEFICIENCY IN A MOUSE MODEL OF TAUOPATHY	188
Martín M.	237
S2-03ADENOSINE RECEPTORS AS A PRIMARY TARGET FOR RESVERATROL: FROM ANTITUMORAL TO NEUROPROTECTION ACTION	31
P.69RESVERATROL ACTS THROUGH ADENOSINE RECEPTORS IN TUMORAL CELL LINES	195
Martinez A.	237
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Martinez C.	237
S14-03INVOLVEMENT OF P2X7 RECEPTOR ON THE ALZHEIMER DISEASE PROGRESSION, THERAPEUTIC IMPLICATIONS	91
P.34REGULATION OF THE UBIQUITIN-PROTEASOME SYSTEM BY P2X7 RECEPTOR, RELEVANCE ON NEUROLOGICAL PATHOLOGIES.	160
Martinez M.	237
S2-05DRUG-INDUCED CARDIOVASCULAR TOXICITY MEDIATED BY P2X7 RECEPTORS: THE EXAMPLE OF ABACAVIR	33
Martini C.	237
P.47PHYSICAL AND FUNCTIONAL INTERACTION BETWEEN GPR17 AND THE CHEMOKINE RECEPTOR 2: A PROMISING TOOL FOR MANAGING REMYELINATION	173
P.70EXTRACELLULAR ADENOSINE PROMOTES GLIOBLASTOMA INVASIVENESS THROUGH THE MODULATION OF MESENCHYMAL STEM CELL SECRETOME	196
Marucci G.	237
S11-04STRUCTURAL INSIGHTS INTO MODIFICATIONS TO THE ATP MOLECULE TUNING ITS AGONIST-TO-ANTAGONIST ACTIVITY AT THE P2X RECEPTORS	77
P.83NEW 4’-TETRAZOLYL ADENOSINE DERIVATIVES AS POTENTIAL AGENTS FOR WOUND HEALING	209
Massari C.	237
S12-01GUANOSINE-INDUCED NEUROPROTECTION: A ROLE FOR ADENOSINE RECEPTOR OLIGOMERS?	79
Mateus M.	237
P.76ADENOSINE A2A RECEPTOR MODULATION OF MICROGLIA MORPHOLOGIC REMODELLING IN EARLY NEURODEVELOPMENT - GENDER BIAS IN PHYSIOLOGY AND PSYCHIATRIC DISORDERS	202
Mato S.	237
S19-02ADDRESSING THE ROLE OF P2X7 RECEPTORS IN PRIMARY DEMYELINATION AND REMYELINATION	116
Matute C.	237
Simposium 19: IMPACT OF PURINERGIC SIGNALLING IN MULTIPLE SCLEROSIS PATHOLOGY	114
S19-04P2X4 RECEPTOR CONTROLS MICROGLIA ACTIVATION AND FAVOURS REMYELINATION IN AUTOIMMUNE ENCEPHALITIS	118
Maza R.	237
P.45ARE micro-RNAs THERAPEUTIC TARGETS FOR SPINAL CORD INJURY EXCITOTOXICITY? microRNA-135a-5p REDUCES P2X7-DEPENDENT RISE IN INTRACELLULAR CALCIUM AND PROTECTS AGAINST EXCITOTOXICITY.	171
McIntosh J.M.	237
S1-01OVEREXPRESSION OF P2X3 AND P2X7 RECEPTORS AND TRPV1 CHANNELS IN ADRENOMEDULLARY CHROMAFFIN CELLS IN A RAT MODEL OF NEUROPATHIC PAIN	24
Mediero A	237
P.96PANNEXIN1 KO MICE ARE IRRESPONSIVE TO TENOFOVIR INDUCED BONE LOSS	222
P.100TENOFOVIR CAUSES BONE LOSS VIA DECREASED BONE FORMATION AND INCREASED BONE RESORPTION, WHICH CAN BE COUNTERACTED BY ADENOSINE A2A RECEPTOR IN MICE	226
Meier C.	237
P3. PHARMACOLOGY AND BIOCHEMISTRY OF P2 RECEPTORSP.14FLUORESCENT SENSORS FOR THE IMAGING OF ATP AT CELL SURFACES	140
P.79COLLABORATIVE RESEARCH CENTER SFB 1328: ADENINE NUCLEOTIDES IN IMMUNITY AND INFLAMMATION	205
Menendez A.	237
S5-03LIVE IMAGING AND SINGLE CELL TRACKING REVEALS CELL DYNAMICS FROM EARLY CEREBELLAR NEURAL STEM CELLS. ROLE OF VNUT IN THEIR LINEAGE PROGRESSION.	47
P5. VESICULAR AND MEMBRANE TRANSPORTERSP.28ANALYSIS OF THE EXPRESION AND FUNCTION OF VNUT IN POSTNATAL CEREBELLUM	154
Mériaux C.	237
P.63NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES MEMORY DEFICITS IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE.	189
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS	192
Merkus D.	237
P.89THE ACTIVATION OF ADENOSINE A2A BUT NOT A2B RECEPTORS IS INVOLVED IN URIDINE ADENOSINE TETRAPHOSPHATE-MEDIATED CORONARY SMOOTH MUSCLE RELAXATION	215
Mertens T.	237
S7-01ADENOSINE AT THE CROSS-ROADS OF LUNG FIBROSIS AND PULMONARY HYPERTENSION	54
Mestre A.	237
P.19EXTRACELLULAR NUCLEOTIDE METABOLISM IN THE CONTEXT OF YEAST-HOST INTERACTION	145
Meyer J.	237
P.19EXTRACELLULAR NUCLEOTIDE METABOLISM IN THE CONTEXT OF YEAST-HOST INTERACTION	145
Mikolajewicz N.	237
P.99ROLE OF UDP-GLUCOSE RECEPTOR P2Y14 IN OSTEOBLASTS	225
Milenkovic I.	237
P.56PARACRINE SIGNALING VIA P2X2/3R IS REQUIRED FOR FUNCTIONAL DEVELOPMENT OF A CENTRAL AUDITORY SYNAPSE	182
Mira H.	237
S15-01ADENOSINE A2A RECEPTORS AND BDNF: AN INTIMATE INTERACTION REGULATING POSTNATAL HIPPOCAMPAL NEUROGENESIS	94
P.103POSTNATAL SUBVENTRICULAR ZONE NEUROGENESIS: ADENOSINE A2A RECEPTORS AS REGULATORS OF BRAIN-DERIVED NEUROTROPHIC FACTOR	229
Miranda C.	237
P.36ADENOSINERGIC SYSTEM: NOVEL THERAPEUTIC TARGET FOR RETT SYNDROME	162
Miranda I.	237
P.102SIGNIFICANCE OF ADENOSINE A2A RECEPTORS IN THE COMMENSAL-PATHOGEN SWITCH IN THE ELDERLY GUT	228
Miras M.T.	237
S1-01OVEREXPRESSION OF P2X3 AND P2X7 RECEPTORS AND TRPV1 CHANNELS IN ADRENOMEDULLARY CHROMAFFIN CELLS IN A RAT MODEL OF NEUROPATHIC PAIN	24
S2-04CROSS-TALK BETWEEN P2 RECEPTORS AND TYROSINE KINASE RECEPTORS IN CEREBELLAR ASTROCYTES	32
S5-03LIVE IMAGING AND SINGLE CELL TRACKING REVEALS CELL DYNAMICS FROM EARLY CEREBELLAR NEURAL STEM CELLS. ROLE OF VNUT IN THEIR LINEAGE PROGRESSION.	47
S10-04REGULATION OF P2X7 RECEPTOR GENE EXPRESSION IN NEUROBLASTOMA CELLS	72
P.25ECTO-NUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE (E-NPP) ACTIVITY IN NEURO-2A NEUROBLASTOMA CELLS	151
P5. VESICULAR AND MEMBRANE TRANSPORTERSP.28ANALYSIS OF THE EXPRESION AND FUNCTION OF VNUT IN POSTNATAL CEREBELLUM	154
P6. PURINERGIC SIGNALING IN NERVOUS SYSTEMP.29ANATOMIC STUDY OF THE CENTRAL NERVOUS SYSTEM DEVELOPMENT EMPLOYING THE MOUSE STRAIN P2rx7-EGFP.	155
P.46AGE-RELATED NUCLEAR TRANSLOCATION OF P2X6 SUBUNIT MODIFIES SPLICING ACTIVITY INTERACTING WITH SPLICING FACTOR 3A1	172
P.53P2X7 RECEPTOR REGULATES THE INDUCIBLE NUCLEAR DUAL-SPECIFICITY PHOSPHATASE 1 IN RAT CEREBELLAR ASTROCYTES	179
P.59P2X7 AND BDNF RECEPTORS CONVERGE TO SHAPE ERK SIGNALLING IN NEURONS THROUGH THE MODULATION OF ERK-DIRECTED PROTEIN PHOSPHATASES	185
P.71INHIBITION OF DUAL-SPECIFICITY PHOSPHATASES PROMOTES P2X7 RECEPTOR EXPRESSION IN NEUROBLASTOMA CELLS IN A p38-DEPENDENT MANNER	197
Mirza S.	237
S18-01A QUEST FOR A DISEASE MODIFYING DRUG FOR THE TREATMENT OF OSTEOARTHRITIS-RELATED CALCIUM PYROPHOSPHATE DEPOSITION DISEASE	110
P.07DEVELOPMENT OF NPP1 INHIBITORS AS POTENTIAL DRUGS FOR THE TREATMENT OF OSTEOARTHRITIS/CPPD DISEASE	133
Mittrücker H.	237
P4. ECTONUCLEOTIDASESP.18T CELL-DERIVED EXOSOMAL CD73 MEDIATES IMMUNE SUPPRESSION	144
Mlejnek P.	237
P.72EFFECT OF WEAK BASE DRUGS ON LYSOSOMAL CAPACITY OF CANCER CELLS: POSSIBLE INVOLVEMENT OF P2X4 RECEPTOR.	198
Mokdad A.	238
P1. STRUCTURE OF PURINE RECEPTORS AND ECTONUCLEOTIDASESP.01IDENTIFICATION OF P2X7 RECEPTOR EXTRACELLULAR VESTIBULE RESIDUES CONTRIBUTING TO RECEPTOR STRUCTURE AND CHANNEL GATING	127
Montenegro F.	238
P.06ALFAXOLONE-INDUCED P2X4R ALLOSTERIC AGONISM CONFIRMED BY MOLECULAR DYNAMIC CALCULATIONS	132
Montesinos C.	238
Simposium 20: FIGHTING THE FIRE: NOVEL PURINERGIC APPROACHES TO MANAGE IMMUNE-MEDIATED DISORDERS	119
Montesinos M.	238
P.78ADENOSINE A2B RECEPTOR ACTIVATION IMPROVES EPIDERMAL BARRIER INTEGRITY DAMPENED BY INFLAMMATION	204
P.82THERAPEUTIC POTENTIAL OF ADENOSINE IN INFLAMMATORY SKIN DISEASES	208
Montilla A.	238
S19-04P2X4 RECEPTOR CONTROLS MICROGLIA ACTIVATION AND FAVOURS REMYELINATION IN AUTOIMMUNE ENCEPHALITIS	118
Morabito C.	238
P.15P2X7 RECEPTOR MODULATES THE OSTEOGENIC DIFFERENTIATION OF STROMAL STEM CELLS FROM HUMAN ADIPOSE TISSUE	141
Moreira S.	238
P.95β3-ADRENOCEPTOR COUPLING TO EPAC1 AND PKC PROMOTES ADENOSINE RELEASE VIA ENT1 LEADING TO INHIBITION OF CHOLINERGIC NEUROTRANSMISSION IN THE HUMAN BLADDER	221
Morello S.	238
P.21ANALYSIS OF CD73 IN SERUM OF CANCER PATIENTS AND HEALTHY DONORS	147
P.81ROLE OF CD73 IN THE DEVELOPMENT OF MURINE ALLERGIC ASTHMA	207
Moreno V.	238
S15-02CORTICAL NEURONAL MIGRATION ENTAILS A2A RECEPTOR-DRIVEN NEURONAL POLARIZATION AND AXON FORMATION	95
Morgan J.	238
P.35THE CONTRIBUTION OF THE P2X7R TO DRUG REFRACTORY STATUS EPILEPTICUS	161
Mota M.	238
P.102SIGNIFICANCE OF ADENOSINE A2A RECEPTORS IN THE COMMENSAL-PATHOGEN SWITCH IN THE ELDERLY GUT	228
Mouro F.	238
P.39ADENOSINE-MEDIATED CONTROL OF SYNAPTIC AND BEHAVIOURAL ACTIONS OF CANNABINOIDS	165
P.51FACILITATION OF SYNAPTIC, BUT NOT EXTRASYNAPTIC, NMDA CURRENTS IN CA1 PYRAMIDAL NEURONS BY ADENOSINE A2AR IN YOUNG ADULT RATS.	177
Mühleder S.	238
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING.	213
Müller C.	238
S3-04PURINERGIC SIGNALING SHAPES MICROGLIAL FUNCTIONS IN ALZHEIMER’S DISEASE	38
Simposium 18: MEDICINAL CHEMISTRY OF PURINE TARGETS	109
S18-01A QUEST FOR A DISEASE MODIFYING DRUG FOR THE TREATMENT OF OSTEOARTHRITIS-RELATED CALCIUM PYROPHOSPHATE DEPOSITION DISEASE	110
P.07DEVELOPMENT OF NPP1 INHIBITORS AS POTENTIAL DRUGS FOR THE TREATMENT OF OSTEOARTHRITIS/CPPD DISEASE	133
P.12DEVELOPMENT OF A LIVE CELL NANOBRET BINDING ASSAY FOR ADENOSINE A2B RECEPTORS	138
P4. P18 ECTONUCLEOTIDASESP.18T CELL-DERIVED EXOSOMAL CD73 MEDIATES IMMUNE SUPPRESSION	144
P.22INVESTIGATION OF HEPARIN-INDUCED ECTONUCLEOTIDASE-INHIBITION TO COUNTERACT ADENOSINE-MEDIATED IMMUNOSUPPRESSION IN THE TUMOR MICROENVIRONMENT	148
P.23DEVELOPMENT OF A HIGH-THROUGHPUT SCREENING ASSAY FOR THE IDENTIFICATION AND CHARACTERIZATION OF NUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE 4 (NPP4) INHIBITORS	149
P.24URIDINE- AND CYTIDINE-BASED ECTO-5ꞌ-NUCLEOTIDASE-INHIBITORS: A NOVEL CLASS OF HIGHLY ACTIVE AND SELECTIVE CD73-INHIBITORS	150
P.27SYNTHESIS OF FLUORESCENCE-LABELED AMP AND ADENOSINE DERIVATIVES AS TOOLS FOR MONITORING CD73 ACTIVITY	153
P.39ADENOSINE-MEDIATED CONTROL OF SYNAPTIC AND BEHAVIOURAL ACTIONS OF CANNABINOIDS	165
P.52SYNAPTIC DYSFUNCTIONS AT THE HIPPOCAMPUS OF AN AMYOTROPHIC LATERAL SCLEROSIS MOUSE MODEL (SOD1G93A): REVERSAL BY ADENOSINE A2AR BLOCKADE	178
P.79COLLABORATIVE RESEARCH CENTER SFB 1328: ADENINE NUCLEOTIDES IN IMMUNITY AND INFLAMMATION	205
Muñoz S.	238
P.69RESVERATROL ACTS THROUGH ADENOSINE RECEPTORS IN TUMORAL CELL LINES	195
Muñoz T.	238
P.45ARE micro-RNAs THERAPEUTIC TARGETS FOR SPINAL CORD INJURY EXCITOTOXICITY? microRNA-135a-5p REDUCES P2X7-DEPENDENT RISE IN INTRACELLULAR CALCIUM AND PROTECTS AGAINST EXCITOTOXICITY.	171
Muoboghare M.	238
P.17CHARACTERISATION OF P2Y2 RECEPTORS IN HUMAN VASCULAR ENDOTHELIAL CELLS USING AR-C118925XX, A POTENT AND SELECTIVE P2Y2 ANTAGONIST	143
Murrell R.	238
S10-01THE ROLE OF THE P2X4 RECEPTOR IN BREAST CANCER	69
Mustafa S.	238
P.89THE ACTIVATION OF ADENOSINE A2A BUT NOT A2B RECEPTORS IS INVOLVED IN URIDINE ADENOSINE TETRAPHOSPHATE-MEDIATED CORONARY SMOOTH MUSCLE RELAXATION	215
Mut P.	238
P.61DENDRITIC OUTGROWTH ALTERATIONS DURING THE PATHOGENESIS OF SCHIZOPHRENIA IN GENETIC MOUSE MODELS OF P2X7R	187
Naaldijk Y.	238
P.31INHIBITION OF THE DOPAMINE TRANSPORTER AS AN ANIMAL MODEL OF MANIA MODULATES ADENOSINE RECEPTORS AND INFLAMMATORY RESPONSES IN THE BRAIN	157
Namasivayam V.	238
P.24URIDINE- AND CYTIDINE-BASED ECTO-5ꞌ-NUCLEOTIDASE-INHIBITORS: A NOVEL CLASS OF HIGHLY ACTIVE AND SELECTIVE CD73-INHIBITORS	150
Narros P.	238
P.16DESIGN, SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF NOVEL P2X7R ANTAGONISTS POTENTIALLY TARGETING THE CNS	142
Nassir M.	238
S18-01A QUEST FOR A DISEASE MODIFYING DRUG FOR THE TREATMENT OF OSTEOARTHRITIS-RELATED CALCIUM PYROPHOSPHATE DEPOSITION DISEASE	110
P.07DEVELOPMENT OF NPP1 INHIBITORS AS POTENTIAL DRUGS FOR THE TREATMENT OF OSTEOARTHRITIS/CPPD DISEASE	133
Navarro G.	238
S9-03ADENOSINE HETERORECEPTOR COMPLEXES IN THE BASAL GANGLIA ARE IMPLICATED IN PARKINSON DISEASE AND ITS TREATMENT	66
S9-04ADENOSINE A2A RECEPTOR ACTIVATION ATTENUATE NMDA RECEPTOR FUNCTION IN ALZHEIMER DISEASE	67
P.58ADENOSINE A2A RECEPTOR ANTAGONISTS POTENTIATE CANNABINOID SIGNALING IN MICROGLIA	184
P11. PURINERGIC SIGNALING INOTHER FUNCTIONSP.101HETERODIMERIZATION OF ADENOSINE RECEPTORS IN BROWN ADIPOSE TISSUE	227
Navia M.	238
P.83NEW 4’-TETRAZOLYL ADENOSINE DERIVATIVES AS POTENTIAL AGENTS FOR WOUND HEALING	209
Nerlich J.	238
P.56PARACRINE SIGNALING VIA P2X2/3R IS REQUIRED FOR FUNCTIONAL DEVELOPMENT OF A CENTRAL AUDITORY SYNAPSE	182
NeuroCEB Brain Bank	238
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Ngouadijeu M.	238
P.83NEW 4’-TETRAZOLYL ADENOSINE DERIVATIVES AS POTENTIAL AGENTS FOR WOUND HEALING	209
Nicke A.	238
Simposium 6: NEW GENETIC TOOLS FOR UNDERSTANDING CELL-SPECIFIC PURINOCEPTOR FUNCTION IN HEALTH AND DISEASES	48
S6-03IN-SITU CROSS-LINKING OF P2X7 COMPLEXES TO IDENTIFY PROTEIN-PROTEIN INTERACTIONS	51
S6-04IMMUNE CELLS FROM P2X4KO MICE EXHIBIT ALTERED P2X7 EXPRESSION AND FUNCTION	52
S14-02BAC TRANSGENIC MOUSE MODELS TO STUDY P2X7 EXPRESSION AND INTERACTIONS	90
P.32COMPARISON OF P2X7 PROTEIN EXPRESSION IN TWO BAC-TRANSGENIC REPORTER MOUSE MODELS	158
P.35THE CONTRIBUTION OF THE P2X7R TO DRUG REFRACTORY STATUS EPILEPTICUS	161
Nicole O.	238
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Niemann B.	238
P.104ROLE OF ADENOSINE IN ADIPOSE TISSUE FIBROSIS	230
Niesel K.	238
P.20P.A METABOLIC IMMUNE CHECKPOINT: ADENOSINE IN BRAIN METASTASES TUMOR MICROENVIRONMENT	146
Nieto M.	238
P.45ARE micro-RNAs THERAPEUTIC TARGETS FOR SPINAL CORD INJURY EXCITOTOXICITY? microRNA-135a-5p REDUCES P2X7-DEPENDENT RISE IN INTRACELLULAR CALCIUM AND PROTECTS AGAINST EXCITOTOXICITY.	171
Nijmeh H.	238
S7-04EXTRACELLULAR ATP REGULATES ANGIOGENIC RESPONSES IN VASA VASORUM ENDOTHELIAL CELLS VIA THE ACTIVATION OF PI3K-AKT-mTOR SIGNALING AXIS AND C-JUN, FOXO3A, AND C-MYC TRANSCRIPTION FACTORS	57
Nikiforov M.	238
S7-02GUANOSINE/GUANYLATE-DEPENDENT REGULATION OF SIGNAL TRANSDUCTION IN CANCER CELLS	55
Nikolic L.	238
S16-02ASTROCYTE PURINERGIC SIGNALING ENHANCES EXCITATORY SYNAPTIC TRANSMISSION DURING EPILEPTOGENESIS	100
Nobili P.	238
S16-02ASTROCYTE PURINERGIC SIGNALING ENHANCES EXCITATORY SYNAPTIC TRANSMISSION DURING EPILEPTOGENESIS	100
Norman D.	238
P.67BLOOD PURINE CONCENTRATION AS A NOVEL DIAGNOSTIC FOR SEIZURES AND EPILEPSY	193
Noronha J.	238
P.30NICOTINIC α7 RECEPTOR-INDUCED ADENOSINE RELEASE FROM PERISYNAPTIC SCHWANN CELLS CONTROLS ACETYLCHOLINE SPILLOVER FROM THE RAT MOTOR ENDPLATE	156
P10. PURINERGIC SIGNALING IN RENAL, GASTROINTESTINAL AND MUSCULOSKELETAL SYSTEMP.92ADP-INDUCED P2Y1-MEDIATED OSTEOGENESIS IS DOWNREGULATED BY OVEREXPRESSED P2Y12 AND P2Y13 RECEPTORS IN POSTMENOPAUSAL MESENCHYMAL STEM CELLS	218
Novak I.	238
S10-03ROLE OF PURINERGIC SIGNALIN IN PANCREATIC CANCER	71
Novio S.	238
P.11A2B ANTAGONIST AS ANTIMETASTATIC AGENTS: DESIGN, SYNTHESIS AND OPTIMIZATION OF NOVEL CHEMOTYPES	137
Núñez M.	238
P.11A2B ANTAGONIST AS ANTIMETASTATIC AGENTS: DESIGN, SYNTHESIS AND OPTIMIZATION OF NOVEL CHEMOTYPES	137
Oliveira L.	238
P.30NICOTINIC α7 RECEPTOR-INDUCED ADENOSINE RELEASE FROM PERISYNAPTIC SCHWANN CELLS CONTROLS ACETYLCHOLINE SPILLOVER FROM THE RAT MOTOR ENDPLATE	156
Orioli E.	238
S10-02P2X7 RECEPTOR IS A KEY REGULATOR OF ATP CONTENT AND IMMUNE INFILTRATION IN THE TUMOR MICROENVIRONMENT	70
P.15P2X7 RECEPTOR MODULATES THE OSTEOGENIC DIFFERENTIATION OF STROMAL STEM CELLS FROM HUMAN ADIPOSE TISSUE	141
P.73P2X7 RECEPTOR INFLUENCES METASTATIC POTENTIAL AND VESICULAR RELEASE IN MELANOMA	199
Ortega F.	238
S5-03LIVE IMAGING AND SINGLE CELL TRACKING REVEALS CELL DYNAMICS FROM EARLY CEREBELLAR NEURAL STEM CELLS. ROLE OF VNUT IN THEIR LINEAGE PROGRESSION.	47
S10-04REGULATION OF P2X7 RECEPTOR GENE EXPRESSION IN NEUROBLASTOMA CELLS	72
P.25ECTO-NUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE (E-NPP) ACTIVITY IN NEURO-2A NEUROBLASTOMA CELLS	151
P.28ANALYSIS OF THE EXPRESION AND FUNCTION OF VNUT IN POSTNATAL CEREBELLUM	154
P.29ANATOMIC STUDY OF THE CENTRAL NERVOUS SYSTEM DEVELOPMENT EMPLOYING THE MOUSE STRAIN P2rx7-EGFP.	155
P.71INHIBITION OF DUAL-SPECIFICITY PHOSPHATASES PROMOTES P2X7 RECEPTOR EXPRESSION IN NEUROBLASTOMA CELLS IN A p38-DEPENDENT MANNER	197
Ortega R.	238
S2-05DRUG-INDUCED CARDIOVASCULAR TOXICITY MEDIATED BY P2X7 RECEPTORS: THE EXAMPLE OF ABACAVIR	33
Otrokocsi L.	238
P.44NLRP3 INFLAMMASOME PATHWAY MEDIATES THE EFFECT P2X7 RECEPTOR ACTIVATION IN THE MATERNAL IMMUNE ACTIVATION MODEL OF AUTISM	170
P.49CONTRIBUTION OF P2Y12 RECEPTORS TO ANIMAL MODEL OF NTG-INDUCED MIGRAINE-ASSOCIATED PAIN	175
Owenier C.	238
P.90PURINE METABOLISM IN CARDIAC FIBROBLASTS AND EPICARDIUM-DERIVED CELLS, SIMULTANEOUSLY ISOLATED FROM THE INFARCTED MOUSE HEART	216
Pallas M.	238
S2-03ADENOSINE RECEPTORS AS A PRIMARY TARGET FOR RESVERATROL: FROM ANTITUMORAL TO NEUROPROTECTION ACTION	31
Pallini R.	238
P.02P2X7 RECEPTOR ACTIVATION INCREASESMESENCHYMAL TRANSDIFFERENTIATION AND INVASIVENESS OF GLIOBLASTOMA-DERIVED STEM-LIKE CELLS	128
Palminha C.	238
P.36ADENOSINERGIC SYSTEM: NOVEL THERAPEUTIC TARGET FOR RETT SYNDROME	162
Palomera V.	238
S2-03ADENOSINE RECEPTORS AS A PRIMARY TARGET FOR RESVERATROL: FROM ANTITUMORAL TO NEUROPROTECTION ACTION	31
Paniagua L.	238
S2-04CROSS-TALK BETWEEN P2 RECEPTORS AND TYROSINE KINASE RECEPTORS IN CEREBELLAR ASTROCYTES	32
S5-03LIVE IMAGING AND SINGLE CELL TRACKING REVEALS CELL DYNAMICS FROM EARLY CEREBELLAR NEURAL STEM CELLS. ROLE OF VNUT IN THEIR LINEAGE PROGRESSION.	47
P.28ANALYSIS OF THE EXPRESION AND FUNCTION OF VNUT IN POSTNATAL CEREBELLUM	154
P.53P2X7 RECEPTOR REGULATES THE INDUCIBLE NUCLEAR DUAL-SPECIFICITY PHOSPHATASE 1 IN RAT CEREBELLAR ASTROCYTES	179
Pankratov Y.	238
Simposium 13: ROLE FOR PURINES IN BI-DIRECTIONAL GLIA-NEURON COMMUNICATIONS	83
S13-02ATP IN ASTROGLIAL CONTROL OF SYNAPTIC PLASTICITY IN AGEING AND AD	85
Paramos de Carvalho D.	238
P.93ADENOSINE A2A RECEPTOR ACTIVATION PROMOTES FIBROSIS BY FAVORING PANNEXIN-1 OVEREXPRESSION IN HUMAN SUBCUTANEOUS FIBROBLASTS	219
Parilla M.	238
P.64THE ADP RECEPTOR P2Y13 IS SELECTIVELY EXPRESSED IN BRAIN MICROGLIA AND CONSTITUTIVELY ATTENUATES HIPPOCAMPAL NEUROGENESIS	190
Parolisi R.	238
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
Parravicini C.	238
P.47PHYSICAL AND FUNCTIONAL INTERACTION BETWEEN GPR17 AND THE CHEMOKINE RECEPTOR 2: A PROMISING TOOL FOR MANAGING REMYELINATION	173
Passaro A.	238
P.85THE P2X7 RECEPTOR IS SHED INTO CIRCULATION AND CORRELATES WITH C-REACTIVE PROTEIN LEVELS	211
Pastor M.	238
Simposium 5: MEMBRANE TRANSPORTERS AND PURINERGIC SIGNALLING	44
Pedata F.	238
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
Simposium 16: ROLE OF PURINES IN GLIAL CELL, PROLIFERATION, MATURATION AND CELL-TO-CELL COMMUNICATION IN THE CENTRAL NERVOUS SYSTEM	98
S16-05THE SELECTIVE STIMULATION OF ADENOSINE A3 RECEPTOR INHIBITS N-TYPE CA2+ CURRENTS IN RAT DORSAL ROOT GANGLION NEURONS	103
P.57ADENOSINE A2B RECEPTORS AND SPHINGOSINE KINASE/SPHINGOSINE 1-PHOSPHATE SIGNALING AXIS CONTROL MATURATION OF OLIGODENDROCYTE PRECURSOR CELLS IN VITRO	183
P.65PROTECTIVE EFFECT OF THE ADENOSINE A2B RECEPTOR AGONIST, BAY60-6583, IN A RAT MODEL OF TRANSIENT CEREBRAL ISCHEMIA.	191
Pegoraro A.	238
S10-02P2X7 RECEPTOR IS A KEY REGULATOR OF ATP CONTENT AND IMMUNE INFILTRATION IN THE TUMOR MICROENVIRONMENT	70
P.73P2X7 RECEPTOR INFLUENCES METASTATIC POTENTIAL AND VESICULAR RELEASE IN MELANOMA	199
Peixoto A.	238
P.30NICOTINIC α7 RECEPTOR-INDUCED ADENOSINE RELEASE FROM PERISYNAPTIC SCHWANN CELLS CONTROLS ACETYLCHOLINE SPILLOVER FROM THE RAT MOTOR ENDPLATE	156
Pelegrín P.	238
S20-01P2X7 RECEPTOR EXPRESSION AND FUNCTION IN HUMAN SEPSIS	120
Pellegrini C.	238
P.74THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF AR170, A POTENT AND SELECTIVE A3 RECEPTOR AGONIST, IN A RAT MODEL OF COLITIS	200
P.97ADENOSINE A2B RECEPTORS ON ENTERIC GLIA MEDIATE COLONIC DYSMOTILITY ASSOCIATED WITH HIGH FAT DIET-INDUCED OBESITY	223
Pelletier J.	238
S18-01A QUEST FOR A DISEASE MODIFYING DRUG FOR THE TREATMENT OF OSTEOARTHRITIS-RELATED CALCIUM PYROPHOSPHATE DEPOSITION DISEASE	110
Perez A.	238
S19-04P2X4 RECEPTOR CONTROLS MICROGLIA ACTIVATION AND FAVOURS REMYELINATION IN AUTOIMMUNE ENCEPHALITIS	118
Perez R.	238
CPL-04COMINGS AND GOINGS OF SIGNALLING CASCADES ACTIVATED BY NUCLEOTIDES	19
S2-04CROSS-TALK BETWEEN P2 RECEPTORS AND TYROSINE KINASE RECEPTORS IN CEREBELLAR ASTROCYTES	32
S5-03LIVE IMAGING AND SINGLE CELL TRACKING REVEALS CELL DYNAMICS FROM EARLY CEREBELLAR NEURAL STEM CELLS. ROLE OF VNUT IN THEIR LINEAGE PROGRESSION.	47
S10-04REGULATION OF P2X7 RECEPTOR GENE EXPRESSION IN NEUROBLASTOMA CELLS	72
P.28ANALYSIS OF THE EXPRESION AND FUNCTION OF VNUT IN POSTNATAL CEREBELLUM	154
P.53P2X7 RECEPTOR REGULATES THE INDUCIBLE NUCLEAR DUAL-SPECIFICITY PHOSPHATASE 1 IN RAT CEREBELLAR ASTROCYTES	179
P.59P2X7 AND BDNF RECEPTORS CONVERGE TO SHAPE ERK SIGNALLING IN NEURONS THROUGH THE MODULATION OF ERK-DIRECTED PROTEIN PHOSPHATASES	185
P.71INHIBITION OF DUAL-SPECIFICITY PHOSPHATASES PROMOTES P2X7 RECEPTOR EXPRESSION IN NEUROBLASTOMA CELLS IN A p38-DEPENDENT MANNER	197
Perez S.	238
S5-02ROLE OF CONCENTRATIVE NUCLEOSIDE TRANSPORTERS (CNT) IN ADENOSINE TRANSPORT AND METABOLISM	46
Peter J.	238
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
Petrotto E.	238
S12-03IMPACT OF IMP-GMP SPECIFIC 5'-NUCLEOTIDASE ON METABOLIC REGULATION AND DRUG RESISTANCE IN TUMORS	81
Petzold G.	238
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
S3-04PURINERGIC SIGNALING SHAPES MICROGLIAL FUNCTIONS IN ALZHEIMER’S DISEASE	38
Pfeifer A.	238
S9-02ROLE OF ADENOSINE IN METABOLISM	65
P.101HETERODIMERIZATION OF ADENOSINE RECEPTORS IN BROWN ADIPOSE TISSUE	227
P.104ROLE OF ADENOSINE IN ADIPOSE TISSUE FIBROSIS	230
Pietrobono D.	238
P.47PHYSICAL AND FUNCTIONAL INTERACTION BETWEEN GPR17 AND THE CHEMOKINE RECEPTOR 2: A PROMISING TOOL FOR MANAGING REMYELINATION	173
P.70EXTRACELLULAR ADENOSINE PROMOTES GLIOBLASTOMA INVASIVENESS THROUGH THE MODULATION OF MESENCHYMAL STEM CELL SECRETOME	196
Pietrowski M.	238
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Pilch K.	238
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Pill K.	238
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING.	213
Pinheiro A.	238
P.93ADENOSINE A2A RECEPTOR ACTIVATION PROMOTES FIBROSIS BY FAVORING PANNEXIN-1 OVEREXPRESSION IN HUMAN SUBCUTANEOUS FIBROBLASTS	219
Pinheiro H.	238
P.76ADENOSINE A2A RECEPTOR MODULATION OF MICROGLIA MORPHOLOGIC REMODELLING IN EARLY NEURODEVELOPMENT - GENDER BIAS IN PHYSIOLOGY AND PSYCHIATRIC DISORDERS	202
Pinto A.	238
P.21ANALYSIS OF CD73 IN SERUM OF CANCER PATIENTS AND HEALTHY DONORS	147
Pinto R.	238
P.92ADP-INDUCED P2Y1-MEDIATED OSTEOGENESIS IS DOWNREGULATED BY OVEREXPRESSED P2Y12 AND P2Y13 RECEPTORS IN POSTMENOPAUSAL MESENCHYMAL STEM CELLS	218
Pippel A.	238
S8-04STRUCTURE-FUNCTION RELATIONSHIP OF P2X7 RECEPTORS	62
P.08POINT MUTATIONS IN P2X7 RECEPTORS	134
Pizzicotti S.	238
P.85THE P2X7 RECEPTOR IS SHED INTO CIRCULATION AND CORRELATES WITH C-REACTIVE PROTEIN LEVELS	211
Plate K.	238
P.20P.A METABOLIC IMMUNE CHECKPOINT: ADENOSINE IN BRAIN METASTASES TUMOR MICROENVIRONMENT	146
Plescher M.	238
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
Poll S.	238
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
Popkova J.	239
P.98RENAL PAPILLA EXPRESSES HIGH LEVELS OF THE UDP-GLUCOSE RECEPTOR P2RY14	224
Portararo P.	239
S10-02P2X7 RECEPTOR IS A KEY REGULATOR OF ATP CONTENT AND IMMUNE INFILTRATION IN THE TUMOR MICROENVIRONMENT	70
Pougnet J	239
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Prieto R.	239
P.11A2B ANTAGONIST AS ANTIMETASTATIC AGENTS: DESIGN, SYNTHESIS AND OPTIMIZATION OF NOVEL CHEMOTYPES	137
Prigent A.	239
P.62BENEFICIAL EFFECTS OF P2X7R DEFICIENCY IN A MOUSE MODEL OF TAUOPATHY	188
Priglinger E.	239
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING.	213
Proença M.	239
P.09 2-ARYLADENINE DERIVATIVES AS POTENT SCAFFOLDS FOR A1, A3 AND DUAL A1/A3 ADENOSINE RECEPTOR ANTAGONISTS: SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS	135
Pröll J.	239
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING.	213
Puelles L.	239
P.29ANATOMIC STUDY OF THE CENTRAL NERVOUS SYSTEM DEVELOPMENT EMPLOYING THE MOUSE STRAIN P2rx7-EGFP.	155
Pugliese A.	239
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
S16-05THE SELECTIVE STIMULATION OF ADENOSINE A3 RECEPTOR INHIBITS N-TYPE CA2+ CURRENTS IN RAT DORSAL ROOT GANGLION NEURONS	103
P.57ADENOSINE A2B RECEPTORS AND SPHINGOSINE KINASE/SPHINGOSINE 1-PHOSPHATE SIGNALING AXIS CONTROL MATURATION OF OLIGODENDROCYTE PRECURSOR CELLS IN VITRO	183
Queipo M.	239
S2-04CROSS-TALK BETWEEN P2 RECEPTORS AND TYROSINE KINASE RECEPTORS IN CEREBELLAR ASTROCYTES	32
P.28ANALYSIS OF THE EXPRESION AND FUNCTION OF VNUT IN POSTNATAL CEREBELLUM	154
P.53P2X7 RECEPTOR REGULATES THE INDUCIBLE NUCLEAR DUAL-SPECIFICITY PHOSPHATASE 1 IN RAT CEREBELLAR ASTROCYTES	179
P.59P2X7 AND BDNF RECEPTORS CONVERGE TO SHAPE ERK SIGNALLING IN NEURONS THROUGH THE MODULATION OF ERK-DIRECTED PROTEIN PHOSPHATASES	185
Queiroz F.	239
P.54ROLE OF ASTROCYTIC ADENOSINE A2A RECEPTORS IN THE FACILITATION OF SYNAPTIC PLASTICITY IN CORTICO-STRIATAL SYNAPSES	180
Radulovic T.	239
P.56PARACRINE SIGNALING VIA P2X2/3R IS REQUIRED FOR FUNCTIONAL DEVELOPMENT OF A CENTRAL AUDITORY SYNAPSE	182
Raffaele S.	239
S16-01EFFECTS OF ATP-INDUCED MICROGLIAL EXTRACELLULAR VESICLES ON OLIGODENDROCYTE PROGENITORS IN CEREBRAL ISCHEMIA	99
S16-04ACTIVATED MICROGLIA REGULATE THE RESPONSE OF OLIGODENDROCYTE PROGENITORS EXPRESSING THE P2Y-LIKE RECEPTOR GPR17 FOLLOWING CEREBRAL ISCHEMIA	102
Raïch I.	239
S9-04ADENOSINE A2A RECEPTOR ACTIVATION ATTENUATE NMDA RECEPTOR FUNCTION IN ALZHEIMER DISEASE	67
P.58ADENOSINE A2A RECEPTOR ANTAGONISTS POTENTIATE CANNABINOID SIGNALING IN MICROGLIA	184
Rameshwar P.	239
P.31INHIBITION OF THE DOPAMINE TRANSPORTER AS AN ANIMAL MODEL OF MANIA MODULATES ADENOSINE RECEPTORS AND INFLAMMATORY RESPONSES IN THE BRAIN	157
Ramirez A.	239
S14-02BAC TRANSGENIC MOUSE MODELS TO STUDY P2X7 EXPRESSION AND INTERACTIONS	90
P.32COMPARISON OF P2X7 PROTEIN EXPRESSION IN TWO BAC-TRANSGENIC REPORTER MOUSE MODELS	158
Ramirez M.	239
P.34REGULATION OF THE UBIQUITIN-PROTEASOME SYSTEM BY P2X7 RECEPTOR, RELEVANCE ON NEUROLOGICAL PATHOLOGIES.	160
Rassendren F	239
S3-01INVOLVEMENT OF PURINERGIC P2X4 RECEPTORS IN ALZHEIMER DISEASE	35
S6-04IMMUNE CELLS FROM P2X4KO MICE EXHIBIT ALTERED P2X7 EXPRESSION AND FUNCTION	52
Redl H.	239
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING.	213
Rei N.	239
P.52SYNAPTIC DYSFUNCTIONS AT THE HIPPOCAMPUS OF AN AMYOTROPHIC LATERAL SCLEROSIS MOUSE MODEL (SOD1G93A): REVERSAL BY ADENOSINE A2AR BLOCKADE	178
Reichenbach N.	239
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
S3-04PURINERGIC SIGNALING SHAPES MICROGLIAL FUNCTIONS IN ALZHEIMER’S DISEASE	38
Reigada D.	239
P.45ARE micro-RNAs THERAPEUTIC TARGETS FOR SPINAL CORD INJURY EXCITOTOXICITY? microRNA-135a-5p REDUCES P2X7-DEPENDENT RISE IN INTRACELLULAR CALCIUM AND PROTECTS AGAINST EXCITOTOXICITY.	171
Ren W.J.	239
S17-04PURINERGIC SIGNALLING AND ACUPUNCTURE-INDUCED ANALGESIA	108
Renn C.	239
P.07DEVELOPMENT OF NPP1 INHIBITORS AS POTENTIAL DRUGS FOR THE TREATMENT OF OSTEOARTHRITIS/CPPD DISEASE	133
P.24URIDINE- AND CYTIDINE-BASED ECTO-5ꞌ-NUCLEOTIDASE-INHIBITORS: A NOVEL CLASS OF HIGHLY ACTIVE AND SELECTIVE CD73-INHIBITORS	150
Reyes I.	239
S9-04ADENOSINE A2A RECEPTOR ACTIVATION ATTENUATE NMDA RECEPTOR FUNCTION IN ALZHEIMER DISEASE	67
P.58ADENOSINE A2A RECEPTOR ANTAGONISTS POTENTIATE CANNABINOID SIGNALING IN MICROGLIA	184
Rial D.	239
S3-03ATP-DERIVED ADENOSINE CONTROLS SYNAPTIC AND MEMORY DYSFUNCTION IN β-AMYLOID MODELS OF ALZHEIMER’S DISEASE	37
P.54ROLE OF ASTROCYTIC ADENOSINE A2A RECEPTORS IN THE FACILITATION OF SYNAPTIC PLASTICITY IN CORTICO-STRIATAL SYNAPSES	180
Ribeiro F.	239
S15-01ADENOSINE A2A RECEPTORS AND BDNF: AN INTIMATE INTERACTION REGULATING POSTNATAL HIPPOCAMPAL NEUROGENESIS	94
P.103POSTNATAL SUBVENTRICULAR ZONE NEUROGENESIS: ADENOSINE A2A RECEPTORS AS REGULATORS OF BRAIN-DERIVED NEUROTROPHIC FACTOR	229
Ribeiro J.	239
P.39ADENOSINE-MEDIATED CONTROL OF SYNAPTIC AND BEHAVIOURAL ACTIONS OF CANNABINOIDS	165
P.51FACILITATION OF SYNAPTIC, BUT NOT EXTRASYNAPTIC, NMDA CURRENTS IN CA1 PYRAMIDAL NEURONS BY ADENOSINE A2AR IN YOUNG ADULT RATS.	177
P.52SYNAPTIC DYSFUNCTIONS AT THE HIPPOCAMPUS OF AN AMYOTROPHIC LATERAL SCLEROSIS MOUSE MODEL (SOD1G93A): REVERSAL BY ADENOSINE A2AR BLOCKADE	178
Ribeiro S.	239
P.93ADENOSINE A2A RECEPTOR ACTIVATION PROMOTES FIBROSIS BY FAVORING PANNEXIN-1 OVEREXPRESSION IN HUMAN SUBCUTANEOUS FIBROBLASTS	219
Ricci L.	239
P.02P2X7 RECEPTOR ACTIVATION INCREASESMESENCHYMAL TRANSDIFFERENTIATION AND INVASIVENESS OF GLIOBLASTOMA-DERIVED STEM-LIKE CELLS	128
Ricken A.	239
P.98RENAL PAPILLA EXPRESSES HIGH LEVELS OF THE UDP-GLUCOSE RECEPTOR P2RY14	224
Riemma M.	239
P.81ROLE OF CD73 IN THE DEVELOPMENT OF MURINE ALLERGIC ASTHMA	207
Rissiek A.	239
P.18T CELL-DERIVED EXOSOMAL CD73 MEDIATES IMMUNE SUPPRESSION	144
P.68CHARACTIZATION OF CD39 EXPRESSION ON T CELLS IN ACUTE MYELOID LEUKEMIA	194
Rissiek B.	239
S6-04IMMUNE CELLS FROM P2X4KO MICE EXHIBIT ALTERED P2X7 EXPRESSION AND FUNCTION	52
S14-02BAC TRANSGENIC MOUSE MODELS TO STUDY P2X7 EXPRESSION AND INTERACTIONS	90
S19-04P2X4 RECEPTOR CONTROLS MICROGLIA ACTIVATION AND FAVOURS REMYELINATION IN AUTOIMMUNE ENCEPHALITIS	118
Robaye B.	239
P.64THE ADP RECEPTOR P2Y13 IS SELECTIVELY EXPRESSED IN BRAIN MICROGLIA AND CONSTITUTIVELY ATTENUATES HIPPOCAMPAL NEUROGENESIS	190
Rocha A.	239
P.092-ARYLADENINE DERIVATIVES AS POTENT SCAFFOLDS FOR A1, A3 AND DUAL A1/A3 ADENOSINE RECEPTOR ANTAGONISTS: SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS	135
Rocha J.	239
S15-02CORTICAL NEURONAL MIGRATION ENTAILS A2A RECEPTOR-DRIVEN NEURONAL POLARIZATION AND AXON FORMATION	95
Rödel F.	239
P.20P.A METABOLIC IMMUNE CHECKPOINT: ADENOSINE IN BRAIN METASTASES TUMOR MICROENVIRONMENT	146
Rodrigues A.	239
P.102SIGNIFICANCE OF ADENOSINE A2A RECEPTORS IN THE COMMENSAL-PATHOGEN SWITCH IN THE ELDERLY GUT	228
Rodrigues L.	239
P.19EXTRACELLULAR NUCLEOTIDE METABOLISM IN THE CONTEXT OF YEAST-HOST INTERACTION	145
P.102SIGNIFICANCE OF ADENOSINE A2A RECEPTORS IN THE COMMENSAL-PATHOGEN SWITCH IN THE ELDERLY GUT	228
Rodrigues R.	239
P.103POSTNATAL SUBVENTRICULAR ZONE NEUROGENESIS: ADENOSINE A2A RECEPTORS AS REGULATORS OF BRAIN-DERIVED NEUROTROPHIC FACTOR	229
Rodrigues R.J.	239
S15-02CORTICAL NEURONAL MIGRATION ENTAILS A2A RECEPTOR-DRIVEN NEURONAL POLARIZATION AND AXON FORMATION	95
Rodrigues R.S.	239
S15-01ADENOSINE A2A RECEPTORS AND BDNF: AN INTIMATE INTERACTION REGULATING POSTNATAL HIPPOCAMPAL NEUROGENESIS	94
Rodrigues T.	239
P.36ADENOSINERGIC SYSTEM: NOVEL THERAPEUTIC TARGET FOR RETT SYNDROME	162
Roger S	239
S10-01THE ROLE OF THE P2X4 RECEPTOR IN BREAST CANCER	69
Rolshoven G.	239
P.27SYNTHESIS OF FLUORESCENCE-LABELED AMP AND ADENOSINE DERIVATIVES AS TOOLS FOR MONITORING CD73 ACTIVITY	153
Roman A.	239
P.60MITOCHONDRIA ARE A KEY TARGET OF AMYLOID β-DEPENDENT DAMAGE IN MOUSE MICROGLIAL CELLS: ROLE OF THE P2X7 RECEPTOR AND PROTECTION BY NIMODIPINE.	186
P.85THE P2X7 RECEPTOR IS SHED INTO CIRCULATION AND CORRELATES WITH C-REACTIVE PROTEIN LEVELS	211
Rombo D.	239
P.39ADENOSINE-MEDIATED CONTROL OF SYNAPTIC AND BEHAVIOURAL ACTIONS OF CANNABINOIDS	165
P.51FACILITATION OF SYNAPTIC, BUT NOT EXTRASYNAPTIC, NMDA CURRENTS IN CA1 PYRAMIDAL NEURONS BY ADENOSINE A2AR IN YOUNG ADULT RATS.	177
P.52SYNAPTIC DYSFUNCTIONS AT THE HIPPOCAMPUS OF AN AMYOTROPHIC LATERAL SCLEROSIS MOUSE MODEL (SOD1G93A): REVERSAL BY ADENOSINE A2AR BLOCKADE	178
Rong P.	239
S17-02THE ROLE OF PURINE RECEPTOR IN THE TREATMENT OF DEPRESSION BY taVNS	106
P.75P2X7R PLAY AN IMPORTANT ROLE IN ANTIDEPRESSANT EFFECT OF TAVNS	201
Rosse M.	239
P.26MONO-ADP-RIBOSYLATION OF CD73 – A NEW LEVEL OF PURI-NERGIC CONTROL	152
Roszek K.	239
S4-04EMERGING ROLE OF NUCLEOTIDE-METABOLIZING ENZYMES IN REGULATION OF MESENCHYMAL STEM CELLS FATE	43
Roveri V.	239
P.80INVESTIGATION ON THE ROLE OF THE P2X7R-NLRP3-IL-1β AXIS IN THE PATHOGENESIS OF HIDRADENITIS SUPPURATIVA	206
Roviezzo F.	239
P.81ROLE OF CD73 IN THE DEVELOPMENT OF MURINE ALLERGIC ASTHMA	207
Rubin P.	239
S1-02THE ASIC3/P2X3 COGNATE RECEPTOR SENSES ACIDIC AND PURINERGIC PAIN IN A NOVEL MANNER	25
Ruiz C.	239
P.48P2X7 RECEPTOR ANTAGONISM WITH JNJ-47965567 REDUCED BODY WEIGHT LOSS AND DELAYED DISEASE ONSET IN FEMALE AMYOTROPHIC LATERAL SCLEROSIS SOD1G93A MICE	174
Rupert M.	239
P.01IDENTIFICATION OF P2X7 RECEPTOR EXTRACELLULAR VESTIBULE RESIDUES CONTRIBUTING TO RECEPTOR STRUCTURE AND CHANNEL GATING	127
Russeau M.	239
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Russo T.	239
P.19EXTRACELLULAR NUCLEOTIDE METABOLISM IN THE CONTEXT OF YEAST-HOST INTERACTION	145
Salamero A.	239
P.20P.A METABOLIC IMMUNE CHECKPOINT: ADENOSINE IN BRAIN METASTASES TUMOR MICROENVIRONMENT	146
Saleh N.	239
S2-03ADENOSINE RECEPTORS AS A PRIMARY TARGET FOR RESVERATROL: FROM ANTITUMORAL TO NEUROPROTECTION ACTION	31
Salvemini D.	239
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
S1-04TARGETING ADENOSINE RECEPTORS TO TREAT NEUROPATHIC PAIN	27
Sanchez A.	239
S2-05DRUG-INDUCED CARDIOVASCULAR TOXICITY MEDIATED BY P2X7 RECEPTORS: THE EXAMPLE OF ABACAVIR	33
Sánchez de Medina V.	239
P.58ADENOSINE A2A RECEPTOR ANTAGONISTS POTENTIATE CANNABINOID SIGNALING IN MICROGLIA	184
Sanchez Melgar A.	239
S2-03ADENOSINE RECEPTORS AS A PRIMARY TARGET FOR RESVERATROL: FROM ANTITUMORAL TO NEUROPROTECTION ACTION	31
P.69RESVERATROL ACTS THROUGH ADENOSINE RECEPTORS IN TUMORAL CELL LINES	195
Sanchez de la Muela M.	239
S1-01OVEREXPRESSION OF P2X3 AND P2X7 RECEPTORS AND TRPV1 CHANNELS IN ADRENOMEDULLARY CHROMAFFIN CELLS IN A RAT MODEL OF NEUROPATHIC PAIN	24
Sanchez S.	239
S2-02CROSSROAD BETWEEN BIOACTIVE LIPIDS AND PURINERGIC SIGNALLING IN MACROPHAGES	30
Sangaletti S.	239
S10-02P2X7 RECEPTOR IS A KEY REGULATOR OF ATP CONTENT AND IMMUNE INFILTRATION IN THE TUMOR MICROENVIRONMENT	70
Sangyong L.	239
S3-04PURINERGIC SIGNALING SHAPES MICROGLIAL FUNCTIONS IN ALZHEIMER’S DISEASE	38
P.07DEVELOPMENT OF NPP1 INHIBITORS AS POTENTIAL DRUGS FOR THE TREATMENT OF OSTEOARTHRITIS/CPPD DISEASE	133
Sanz J.	239
P.60MITOCHONDRIA ARE A KEY TARGET OF AMYLOID β-DEPENDENT DAMAGE IN MOUSE MICROGLIAL CELLS: ROLE OF THE P2X7 RECEPTOR AND PROTECTION BY NIMODIPINE.	186
P.85THE P2X7 RECEPTOR IS SHED INTO CIRCULATION AND CORRELATES WITH C-REACTIVE PROTEIN LEVELS	211
Sarti A.	239
P.60MITOCHONDRIA ARE A KEY TARGET OF AMYLOID β-DEPENDENT DAMAGE IN MOUSE MICROGLIAL CELLS: ROLE OF THE P2X7 RECEPTOR AND PROTECTION BY NIMODIPINE.	186
P.85THE P2X7 RECEPTOR IS SHED INTO CIRCULATION AND CORRELATES WITH C-REACTIVE PROTEIN LEVELS	211
Saura C.	239
S9-04ADENOSINE A2A RECEPTOR ACTIVATION ATTENUATE NMDA RECEPTOR FUNCTION IN ALZHEIMER DISEASE	67
P.58ADENOSINE A2A RECEPTOR ANTAGONISTS POTENTIATE CANNABINOID SIGNALING IN MICROGLIA	184
Sazdovitch V.	239
P.62BENEFICIAL EFFECTS OF P2X7R DEFICIENCY IN A MOUSE MODEL OF TAUOPATHY	188
Scalbert N.	239
P.32COMPARISON OF P2X7 PROTEIN EXPRESSION IN TWO BAC-TRANSGENIC REPORTER MOUSE MODELS	158
Scaroni F.	239
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
P.55MICROGLIA VERSUS MACROPHAGE EFFECTS ON OLIGODENDROCYTE PRECURSOR CELLS: ROLE OF EXTRACELLULAR VESICLES	181
Schaack J.	239
S7-04EXTRACELLULAR ATP REGULATES ANGIOGENIC RESPONSES IN VASA VASORUM ENDOTHELIAL CELLS VIA THE ACTIVATION OF PI3K-AKT-mTOR SIGNALING AXIS AND C-JUN, FOXO3A, AND C-MYC TRANSCRIPTION FACTORS	57
Schäkel L.	239
P.27SYNTHESIS OF FLUORESCENCE-LABELED AMP AND ADENOSINE DERIVATIVES AS TOOLS FOR MONITORING CD73 ACTIVITY	153
Scheller J.	239
P.86REGULATION OF IL-6 FORMATION IN THE HEART BY CD73-DERIVED ADENOSINE	212
P.91IMPACT OF CD73-DERIVED ADENOSINE ON THE CELL-TYPE SPECIFIC CYTOKINE RESPONSE IN THE INFARCTED MURINE HEART	217
Schiffmann S.	239
P.54ROLE OF ASTROCYTIC ADENOSINE A2A RECEPTORS IN THE FACILITATION OF SYNAPTIC PLASTICITY IN CORTICO-STRIATAL SYNAPSES	180
Schlesinger M.	239
P.22INVESTIGATION OF HEPARIN-INDUCED ECTONUCLEOTIDASE-INHIBITION TO COUNTERACT ADENOSINE-MEDIATED IMMUNOSUPPRESSION IN THE TUMOR MICROENVIRONMENT	148
Schmalzing G.	239
S8-04STRUCTURE-FUNCTION RELATIONSHIP OF P2X7 RECEPTORS	62
P.08POINT MUTATIONS IN P2X7 RECEPTORS	134
Schmid R.	239
S11-01CONFORMATIONAL CHANGE IN P2XR – INSIGHTS FROM MOLECULAR DYNAMICS SIMULATIONS	74
P.04STRUCTURAL MODELS FOR DICTOSTELIUM DISCOIDEUM P2X RECEPTORS	130
P.05UNCOVERING ‘HIDDEN’ CONFORMATIONS OF ATP-GATED P2X RECEPTORS USING BIOCHEMICAL AND BIOINFORMATICS METHODS	131
Schmidt A.	239
S6-03IN-SITU CROSS-LINKING OF P2X7 COMPLEXES TO IDENTIFY PROTEIN-PROTEIN INTERACTIONS	51
Schneider E.	239
P.18T CELL-DERIVED EXOSOMAL CD73 MEDIATES IMMUNE SUPPRESSION	144
Schöneberg T.	239
P.98RENAL PAPILLA EXPRESSES HIGH LEVELS OF THE UDP-GLUCOSE RECEPTOR P2RY14	224
Schrader J.	239
Simposium 2: NEW INSIGHTS INTO PURINERGIC SIGNALING	28
S2-01Jürgen Schrader (IMC/HH University, Dusseldorf, Germany) CD73-derived adenosine in inflammation: mechanisms and relevance	29
P.26MONO-ADP-RIBOSYLATION OF CD73 – A NEW LEVEL OF PURI-NERGIC CONTROL	152
P.86REGULATION OF IL-6 FORMATION IN THE HEART BY CD73-DERIVED ADENOSINE	212
PURINE METABOLISM IN CARDIAC FIBROBLASTS AND EPICARDIUM-DERIVED CELLS, SIMULTANEOUSLY ISOLATED FROM THE INFARCTED MOUSE HEART	216
P.91IMPACT OF CD73-DERIVED ADENOSINE ON THE CELL-TYPE SPECIFIC CYTOKINE RESPONSE IN THE INFARCTED MURINE HEART	217
Schuh H.	239
P.22INVESTIGATION OF HEPARIN-INDUCED ECTONUCLEOTIDASE-INHIBITION TO COUNTERACT ADENOSINE-MEDIATED IMMUNOSUPPRESSION IN THE TUMOR MICROENVIRONMENT	148
Schulte T.	239
S3-02ROLE OF ASTROGLIAL PURINERGIC TRANSMISSION IN ALZHEIMER’S DISEASE	36
Schulz A.	239
P.98RENAL PAPILLA EXPRESSES HIGH LEVELS OF THE UDP-GLUCOSE RECEPTOR P2RY14	224
Schulz M.	239
P.20P.A METABOLIC IMMUNE CHECKPOINT: ADENOSINE IN BRAIN METASTASES TUMOR MICROENVIRONMENT	146
Schulze M.	239
S4-02ENHANCED OSTEOGENESIS AND ANGIOGENESIS FOR PUTATIVE BONE GRAFTS BY ACTIVATING PURINERGIC RECEPTOR SIGNALING DURING MESENCHYMAL STEM CELL DIFFERENTIATION	41
Schulze J.	239
P.68CHARACTIZATION OF CD39 EXPRESSION ON T CELLS IN ACUTE MYELOID LEUKEMIA	194
Schwarz W.	239
S17-01ATP RELEASE FROM MAST CELLS BY ACUPUNCTURE STIMULI	105
Scortchini M.	240
S16-05THE SELECTIVE STIMULATION OF ADENOSINE A3 RECEPTOR INHIBITS N-TYPE CA2+ CURRENTS IN RAT DORSAL ROOT GANGLION NEURONS	103
Sebastian A.	240
S14-03INVOLVEMENT OF P2X7 RECEPTOR ON THE ALZHEIMER DISEASE PROGRESSION, THERAPEUTIC IMPLICATIONS	91
P.34REGULATION OF THE UBIQUITIN-PROTEASOME SYSTEM BY P2X7 RECEPTOR, RELEVANCE ON NEUROLOGICAL PATHOLOGIES.	160
P.46AGE-RELATED NUCLEAR TRANSLOCATION OF P2X6 SUBUNIT MODIFIES SPLICING ACTIVITY INTERACTING WITH SPLICING FACTOR 3A1	172
Sebastião A.	240
S15-01ADENOSINE A2A RECEPTORS AND BDNF: AN INTIMATE INTERACTION REGULATING POSTNATAL HIPPOCAMPAL NEUROGENESIS	94
Simposium 16: ROLE OF PURINES IN GLIAL CELL, PROLIFERATION, MATURATION AND CELL-TO-CELL COMMUNICATION IN THE CENTRAL NERVOUS SYSTEM	98
S16-03ROLE OF ASTROCYTIC ADENOSINE ON THE MODULATION OF SYNAPTIC PLASTICITY BY BDNF	101
P.36ADENOSINERGIC SYSTEM: NOVEL THERAPEUTIC TARGET FOR RETT SYNDROME	162
P.39ADENOSINE-MEDIATED CONTROL OF SYNAPTIC AND BEHAVIOURAL ACTIONS OF CANNABINOIDS	165
P.51FACILITATION OF SYNAPTIC, BUT NOT EXTRASYNAPTIC, NMDA CURRENTS IN CA1 PYRAMIDAL NEURONS BY ADENOSINE A2AR IN YOUNG ADULT RATS.	177
P.52SYNAPTIC DYSFUNCTIONS AT THE HIPPOCAMPUS OF AN AMYOTROPHIC LATERAL SCLEROSIS MOUSE MODEL (SOD1G93A): REVERSAL BY ADENOSINE A2AR BLOCKADE	178
P.103POSTNATAL SUBVENTRICULAR ZONE NEUROGENESIS: ADENOSINE A2A RECEPTORS AS REGULATORS OF BRAIN-DERIVED NEUROTROPHIC FACTOR	229
Seguela P.	240
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
S8-03IDENTIFICATION OF A NON-COMPETITIVE ANTAGONIST SITE IN P2X RECEPTOR CHANNELS	61
Selent J.	240
S2-03ADENOSINE RECEPTORS AS A PRIMARY TARGET FOR RESVERATROL: FROM ANTITUMORAL TO NEUROPROTECTION ACTION	31
Senderowich H.	240
S18-01A QUEST FOR A DISEASE MODIFYING DRUG FOR THE TREATMENT OF OSTEOARTHRITIS-RELATED CALCIUM PYROPHOSPHATE DEPOSITION DISEASE	110
Sennlaub F.	240
P.62BENEFICIAL EFFECTS OF P2X7R DEFICIENCY IN A MOUSE MODEL OF TAUOPATHY	188
Serpa A.	240
P.39ADENOSINE-MEDIATED CONTROL OF SYNAPTIC AND BEHAVIOURAL ACTIONS OF CANNABINOIDS	165
Sevenich L.	240
P.20P.A METABOLIC IMMUNE CHECKPOINT: ADENOSINE IN BRAIN METASTASES TUMOR MICROENVIRONMENT	146
Sévigny J.	240
S18-01A QUEST FOR A DISEASE MODIFYING DRUG FOR THE TREATMENT OF OSTEOARTHRITIS-RELATED CALCIUM PYROPHOSPHATE DEPOSITION DISEASE	110
Shen W.	240
S16-02ASTROCYTE PURINERGIC SIGNALING ENHANCES EXCITATORY SYNAPTIC TRANSMISSION DURING EPILEPTOGENESIS	100
Shoushrah S.	240
S4-02ENHANCED OSTEOGENESIS AND ANGIOGENESIS FOR PUTATIVE BONE GRAFTS BY ACTIVATING PURINERGIC RECEPTOR SIGNALING DURING MESENCHYMAL STEM CELL DIFFERENTIATION	41
Sickmann A.	240
P.26MONO-ADP-RIBOSYLATION OF CD73 – A NEW LEVEL OF PURI-NERGIC CONTROL	152
Siehs C.	240
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING.	213
Silva A.	240
S3-03ATP-DERIVED ADENOSINE CONTROLS SYNAPTIC AND MEMORY DYSFUNCTION IN β-AMYLOID MODELS OF ALZHEIMER’S DISEASE	37
P.39ADENOSINE-MEDIATED CONTROL OF SYNAPTIC AND BEHAVIOURAL ACTIONS OF CANNABINOIDS	165
Silva C	240
P.88POLYPHENOLS INCREASE ATP RELEASE AND NO PRODUCTION BY SEPARATE MECHANISMS IN MESENTERIC ENDOTHELIAL CELL CULTURES.	214
Silva D.	220
P.94URINARY ATP CONCENTRATION IS RELATED TO DETRUSOR PRESSURE DURING VOIDING	220
P.95β3-ADRENOCEPTOR COUPLING TO EPAC1 AND PKC PROMOTES ADENOSINE RELEASE VIA ENT1 LEADING TO INHIBITION OF CHOLINERGIC NEUROTRANSMISSION IN THE HUMAN BLADDER	221
Silva G.	145
P.19EXTRACELLULAR NUCLEOTIDE METABOLISM IN THE CONTEXT OF YEAST-HOST INTERACTION	145
Silva H.	240
S3-03ATP-DERIVED ADENOSINE CONTROLS SYNAPTIC AND MEMORY DYSFUNCTION IN β-AMYLOID MODELS OF ALZHEIMER’S DISEASE	37
P.10PHARMACOLOGICAL BLOCKADE OF ADENOSINE A2A RECEPTORS RECOVERS MOTOR LEARNING AND GRIP STRENGTH DEFICITS IN AN ANGELMAN SYNDROME MOUSE MODEL	136
P.54ROLE OF ASTROCYTIC ADENOSINE A2A RECEPTORS IN THE FACILITATION OF SYNAPTIC PLASTICITY IN CORTICO-STRIATAL SYNAPSES	180
Silva I.	220
P.94URINARY ATP CONCENTRATION IS RELATED TO DETRUSOR PRESSURE DURING VOIDING	220
P.95β3-ADRENOCEPTOR COUPLING TO EPAC1 AND PKC PROMOTES ADENOSINE RELEASE VIA ENT1 LEADING TO INHIBITION OF CHOLINERGIC NEUROTRANSMISSION IN THE HUMAN BLADDER	221
Silva M.	220
P.94URINARY ATP CONCENTRATION IS RELATED TO DETRUSOR PRESSURE DURING VOIDING	220
P.95β3-ADRENOCEPTOR COUPLING TO EPAC1 AND PKC PROMOTES ADENOSINE RELEASE VIA ENT1 LEADING TO INHIBITION OF CHOLINERGIC NEUROTRANSMISSION IN THE HUMAN BLADDER	221
Simeone E	240
P.21ANALYSIS OF CD73 IN SERUM OF CANCER PATIENTS AND HEALTHY DONORS	147
Šimková T.	240
S12-01GUANOSINE-INDUCED NEUROPROTECTION: A ROLE FOR ADENOSINE RECEPTOR OLIGOMERS?	79
Sironi L.	240
S16-01EFFECTS OF ATP-INDUCED MICROGLIAL EXTRACELLULAR VESICLES ON OLIGODENDROCYTE PROGENITORS IN CEREBRAL ISCHEMIA	99
S16-04ACTIVATED MICROGLIA REGULATE THE RESPONSE OF OLIGODENDROCYTE PROGENITORS EXPRESSING THE P2Y-LIKE RECEPTOR GPR17 FOLLOWING CEREBRAL ISCHEMIA	102
Skoupa N.	240
P.72EFFECT OF WEAK BASE DRUGS ON LYSOSOMAL CAPACITY OF CANCER CELLS: POSSIBLE INVOLVEMENT OF P2X4 RECEPTOR	198
Slezak P.	240
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING.	213
Smith J.	240
P.37THE P2X7 RECEPTOR’S CONTRIBUTION TO NEONATAL SEIZURES AND THE DEVELOPMENT OF CHRONIC EPILEPSY AND NEURO-COGNITIVE DEFICITS.	163
P.38CONTROL OF THE BLOOD-BRAIN BARRIER INTEGRITY DURING SEIZURES VIA THE ATP-GATED P2X7 RECEPTOR	164
Soares R.	240
S15-01ADENOSINE A2A RECEPTORS AND BDNF: AN INTIMATE INTERACTION REGULATING POSTNATAL HIPPOCAMPAL NEUROGENESIS	94
P.103POSTNATAL SUBVENTRICULAR ZONE NEUROGENESIS: ADENOSINE A2A RECEPTORS AS REGULATORS OF BRAIN-DERIVED NEUROTROPHIC FACTOR	229
Solá S.	240
P.103POSTNATAL SUBVENTRICULAR ZONE NEUROGENESIS: ADENOSINE A2A RECEPTORS AS REGULATORS OF BRAIN-DERIVED NEUROTROPHIC FACTOR	229
Solar V.	240
S1-01OVEREXPRESSION OF P2X3 AND P2X7 RECEPTORS AND TRPV1 CHANNELS IN ADRENOMEDULLARY CHROMAFFIN CELLS IN A RAT MODEL OF NEUROPATHIC PAIN	24
Sotelo E.	240
S18-03EVOLUTIONARY APPROACHES FOR ADENOSINE RECEPTORS MODULATION	112
P.11A2B ANTAGONIST AS ANTIMETASTATIC AGENTS: DESIGN, SYNTHESIS AND OPTIMIZATION OF NOVEL CHEMOTYPES	137
Soto A.	240
P.45ARE micro-RNAs THERAPEUTIC TARGETS FOR SPINAL CORD INJURY EXCITOTOXICITY? microRNA-135a-5p REDUCES P2X7-DEPENDENT RISE IN INTRACELLULAR CALCIUM AND PROTECTS AGAINST EXCITOTOXICITY.	171
Soto M.	240
P.45ARE micro-RNAs THERAPEUTIC TARGETS FOR SPINAL CORD INJURY EXCITOTOXICITY? microRNA-135a-5p REDUCES P2X7-DEPENDENT RISE IN INTRACELLULAR CALCIUM AND PROTECTS AGAINST EXCITOTOXICITY.	171
Sperlagh B.	240
Simposium 8: NEW INSIGHTS IN P2X RECEPTOR STRUCTURE-FUNCTION	58
S8-02MODULATION OF P2X7 RECEPTOR ACTIVITY BY EXTRACELLULAR ZN2+: IMPLICATIONS FOR MOOD DISORDERS	60
P.41THE EFFECT OF P2X7 RECEPTOR DEFICIENCY ON C-FOS ACTIVATION IN AN ACUTE PCP INDUCED SCHIZOPHRENIA MODEL IN MICE	167
P.43INVOLVEMENT OF P2X7RS IN EXCITATORY NEUROTRANSMISSION IN THE MOUSE DENTATE GYRUS GRANULE CELLS	169
P.44NLRP3 INFLAMMASOME PATHWAY MEDIATES THE EFFECT P2X7 RECEPTOR ACTIVATION IN THE MATERNAL IMMUNE ACTIVATION MODEL OF AUTISM	170
P.49CONTRIBUTION OF P2Y12 RECEPTORS TO ANIMAL MODEL OF NTG-INDUCED MIGRAINE-ASSOCIATED PAIN	175
P.61DENDRITIC OUTGROWTH ALTERATIONS DURING THE PATHOGENESIS OF SCHIZOPHRENIA IN GENETIC MOUSE MODELS OF P2X7R	187
Spina A.	240
P.80INVESTIGATION ON THE ROLE OF THE P2X7R-NLRP3-IL-1β AXIS IN THE PATHOGENESIS OF HIDRADENITIS SUPPURATIVA	206
Spinaci A.	240
P.83NEW 4’-TETRAZOLYL ADENOSINE DERIVATIVES AS POTENTIAL AGENTS FOR WOUND HEALING	209
Stavros A.	240
P.04STRUCTURAL MODELS FOR DICTOSTELIUM DISCOIDEUM P2X RECEPTORS	130
Stavrou A.	240
P.05UNCOVERING ‘HIDDEN’ CONFORMATIONS OF ATP-GATED P2X RECEPTORS USING BIOCHEMICAL AND BIOINFORMATICS METHODS	131
Steckel B.	240
P.26MONO-ADP-RIBOSYLATION OF CD73 – A NEW LEVEL OF PURI-NERGIC CONTROL	152
Stefani J.	240
P.64THE ADP RECEPTOR P2Y13 IS SELECTIVELY EXPRESSED IN BRAIN MICROGLIA AND CONSTITUTIVELY ATTENUATES HIPPOCAMPAL NEUROGENESIS	190
Stein A.	240
P.105P2X7R INDIRECTLY REGULATES THE JAM-A PROTEIN CONTENT VIA MODULATION OF THE GSK-3β AND PKC-β1	231
Stein S.	240
P.20P.A METABOLIC IMMUNE CHECKPOINT: ADENOSINE IN BRAIN METASTASES TUMOR MICROENVIRONMENT	146
Stenmark K.	240
S7-04EXTRACELLULAR ATP REGULATES ANGIOGENIC RESPONSES IN VASA VASORUM ENDOTHELIAL CELLS VIA THE ACTIVATION OF PI3K-AKT-mTOR SIGNALING AXIS AND C-JUN, FOXO3A, AND C-MYC TRANSCRIPTION FACTORS	57
Stephan G.	240
S1-02THE ASIC3/P2X3 COGNATE RECEPTOR SENSES ACIDIC AND PURINERGIC PAIN IN A NOVEL MANNER	25
Stolz M.	240
S8-04STRUCTURE-FUNCTION RELATIONSHIP OF P2X7 RECEPTORS	62
Strassheim D.	240
S7-04EXTRACELLULAR ATP REGULATES ANGIOGENIC RESPONSES IN VASA VASORUM ENDOTHELIAL CELLS VIA THE ACTIVATION OF PI3K-AKT-mTOR SIGNALING AXIS AND C-JUN, FOXO3A, AND C-MYC TRANSCRIPTION FACTORS	57
Sträter N.	240
P.26MONO-ADP-RIBOSYLATION OF CD73 – A NEW LEVEL OF PURI-NERGIC CONTROL	152
Sullivan T.	240
S7-04EXTRACELLULAR ATP REGULATES ANGIOGENIC RESPONSES IN VASA VASORUM ENDOTHELIAL CELLS VIA THE ACTIVATION OF PI3K-AKT-mTOR SIGNALING AXIS AND C-JUN, FOXO3A, AND C-MYC TRANSCRIPTION FACTORS	57
Sun C.	240
P.89THE ACTIVATION OF ADENOSINE A2A BUT NOT A2B RECEPTORS IS INVOLVED IN URIDINE ADENOSINE TETRAPHOSPHATE-MEDIATED CORONARY SMOOTH MUSCLE RELAXATION	215
Szabó D.	240
P.44NLRP3 INFLAMMASOME PATHWAY MEDIATES THE EFFECT P2X7 RECEPTOR ACTIVATION IN THE MATERNAL IMMUNE ACTIVATION MODEL OF AUTISM	170
Szwarc D.	240
P.87THE ENDOTHELIAL P2Y2 RECEPTOR MODULATES SPROUTING.	213
Tang Y.	240
S1-02THE ASIC3/P2X3 COGNATE RECEPTOR SENSES ACIDIC AND PURINERGIC PAIN IN A NOVEL MANNER	25
Simposium 17: ACUPUNCTURE AND PURINERGIC MECHANISM	104
S17-04PURINERGIC SIGNALLING AND ACUPUNCTURE-INDUCED ANALGESIA	108
Tasca C.	240
S12-01GUANOSINE-INDUCED NEUROPROTECTION: A ROLE FOR ADENOSINE RECEPTOR OLIGOMERS?	79
Temido M.	240
P.66NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES TAU PATHOLOGY-ASSOCIATED MEMORY DEFICITS .	192
Terencio M.	240
P.78ADENOSINE A2B RECEPTOR ACTIVATION IMPROVES EPIDERMAL BARRIER INTEGRITY DAMPENED BY INFLAMMATION	204
P.82THERAPEUTIC POTENTIAL OF ADENOSINE IN INFLAMMATORY SKIN DISEASES	208
Therrien E.	240
S8-03IDENTIFICATION OF A NON-COMPETITIVE ANTAGONIST SITE IN P2X RECEPTOR CHANNELS	61
Tobiasch E.	240
S4-02ENHANCED OSTEOGENESIS AND ANGIOGENESIS FOR PUTATIVE BONE GRAFTS BY ACTIVATING PURINERGIC RECEPTOR SIGNALING DURING MESENCHYMAL STEM CELL DIFFERENTIATION	41
Tolosa E.	240
P.18T CELL-DERIVED EXOSOMAL CD73 MEDIATES IMMUNE SUPPRESSION	144
Tomé A.	240
S3-03ATP-DERIVED ADENOSINE CONTROLS SYNAPTIC AND MEMORY DYSFUNCTION IN β-AMYLOID MODELS OF ALZHEIMER’S DISEASE	37
P.10PHARMACOLOGICAL BLOCKADE OF ADENOSINE A2A RECEPTORS RECOVERS MOTOR LEARNING AND GRIP STRENGTH DEFICITS IN AN ANGELMAN SYNDROME MOUSE MODEL	136
P.54ROLE OF ASTROCYTIC ADENOSINE A2A RECEPTORS IN THE FACILITATION OF SYNAPTIC PLASTICITY IN CORTICO-STRIATAL SYNAPSES	180
Tonegato M.	240
P.60MITOCHONDRIA ARE A KEY TARGET OF AMYLOID β-DEPENDENT DAMAGE IN MOUSE MICROGLIAL CELLS: ROLE OF THE P2X7 RECEPTOR AND PROTECTION BY NIMODIPINE.	186
P.85THE P2X7 RECEPTOR IS SHED INTO CIRCULATION AND CORRELATES WITH C-REACTIVE PROTEIN LEVELS	211
Tosh D.	240
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
Toulme E.	240
S6-01INCREASED SURFACE P2X4 RECEPTOR EXPRESSION LEADS TO SYNAPTIC PLASTICITY AND LEARNING DEFICITS IN NON-INTERNALIZED P2X4MCHERRYIN KNOCKIN MICE	49
Tozzi M.G	240
S12-03IMPACT OF IMP-GMP SPECIFIC 5'-NUCLEOTIDASE ON METABOLIC REGULATION AND DRUG RESISTANCE IN TUMORS	81
Trincavelli M.	240
P.47PHYSICAL AND FUNCTIONAL INTERACTION BETWEEN GPR17 AND THE CHEMOKINE RECEPTOR 2: A PROMISING TOOL FOR MANAGING REMYELINATION	173
P.70EXTRACELLULAR ADENOSINE PROMOTES GLIOBLASTOMA INVASIVENESS THROUGH THE MODULATION OF MESENCHYMAL STEM CELL SECRETOME	196
Tschesnokowa O.	240
P.64THE ADP RECEPTOR P2Y13 IS SELECTIVELY EXPRESSED IN BRAIN MICROGLIA AND CONSTITUTIVELY ATTENUATES HIPPOCAMPAL NEUROGENESIS	190
Turiello R.	240
P.21ANALYSIS OF CD73 IN SERUM OF CANCER PATIENTS AND HEALTHY DONORS	147
Tvrdonova V.	240
P.01IDENTIFICATION OF P2X7 RECEPTOR EXTRACELLULAR VESTIBULE RESIDUES CONTRIBUTING TO RECEPTOR STRUCTURE AND CHANNEL GATING	127
Uccelli A.	240
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
Ugolini F.	240
P.65PROTECTIVE EFFECT OF THE ADENOSINE A2B RECEPTOR AGONIST, BAY60-6583, IN A RAT MODEL OF TRANSIENT CEREBRAL ISCHEMIA.	191
Ulmann L.	240
S3-01INVOLVEMENT OF PURINERGIC P2X4 RECEPTORS IN ALZHEIMER DISEASE	35
S16-02ASTROCYTE PURINERGIC SIGNALING ENHANCES EXCITATORY SYNAPTIC TRANSMISSION DURING EPILEPTOGENESIS	100
Ulrich H.	240
P.31INHIBITION OF THE DOPAMINE TRANSPORTER AS AN ANIMAL MODEL OF MANIA MODULATES ADENOSINE RECEPTORS AND INFLAMMATORY RESPONSES IN THE BRAIN	157
Vaz S.	240
S16-03ROLE OF ASTROCYTIC ADENOSINE ON THE MODULATION OF SYNAPTIC PLASTICITY BY BDNF	101
P.52SYNAPTIC DYSFUNCTIONS AT THE HIPPOCAMPUS OF AN AMYOTROPHIC LATERAL SCLEROSIS MOUSE MODEL (SOD1G93A): REVERSAL BY ADENOSINE A2AR BLOCKADE	178
P.103POSTNATAL SUBVENTRICULAR ZONE NEUROGENESIS: ADENOSINE A2A RECEPTORS AS REGULATORS OF BRAIN-DERIVED NEUROTROPHIC FACTOR	229
Verderio C.	240
S16-01EFFECTS OF ATP-INDUCED MICROGLIAL EXTRACELLULAR VESICLES ON OLIGODENDROCYTE PROGENITORS IN CEREBRAL ISCHEMIA	99
S16-04ACTIVATED MICROGLIA REGULATE THE RESPONSE OF OLIGODENDROCYTE PROGENITORS EXPRESSING THE P2Y-LIKE RECEPTOR GPR17 FOLLOWING CEREBRAL ISCHEMIA	102
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
P.55MICROGLIA VERSUS MACROPHAGE EFFECTS ON OLIGODENDROCYTE PRECURSOR CELLS: ROLE OF EXTRACELLULAR VESICLES	181
Verin A.	240
Simposium 7: PURINES AND PURINERGIC RECEPTORS IN VASCULAR INJURY, CANCER, AND INFLAMMATION	53
S7-03DISSECTING THE MECHANISMS OF VASCULAR BARRIER STRENGTHENING IN ACUTE LUNG INJURY: NOVEL MECHANISMS FOR EXTRACELLULAR PURINES	56
Verkhratsky A.	240
Simposium 13: ROLE FOR PURINES IN BI-DIRECTIONAL GLIA-NEURON COMMUNICATIONS	83
Viani P.	240
S19-01DETRIMENTAL AND PROTECTIVE ACTION OF MICROGLIAL EXTRACELLULAR VESICLES ON MYELIN LESIONS: ASTROCYTE INVOLVEMENT IN REMYELINATION FAILURE	115
Vieira C.	240
P.92ADP-INDUCED P2Y1-MEDIATED OSTEOGENESIS IS DOWNREGULATED BY OVEREXPRESSED P2Y12 AND P2Y13 RECEPTORS IN POSTMENOPAUSAL MESENCHYMAL STEM CELLS	218
P.95β3-ADRENOCEPTOR COUPLING TO EPAC1 AND PKC PROMOTES ADENOSINE RELEASE VIA ENT1 LEADING TO INHIBITION OF CHOLINERGIC NEUROTRANSMISSION IN THE HUMAN BLADDER	221
Vielmuth C.	240
P.12DEVELOPMENT OF A LIVE CELL NANOBRET BINDING ASSAY FOR ADENOSINE A2B RECEPTORS	138
Villarejo L.	240
S5-01MODULATION OF NEURONAL GLYCINE TRANSPORT BY P2Y AND P2X RECEPTORS	45
Virenque A.	240
S16-02ASTROCYTE PURINERGIC SIGNALING ENHANCES EXCITATORY SYNAPTIC TRANSMISSION DURING EPILEPTOGENESIS	100
Volonté C.	240
S20-04TARGETING P2X7 IN AMYOTROPHIC LATERAL SCLEROSIS: WHERE AND WHEN?	123
Volpini R.	240
S11-04STRUCTURAL INSIGHTS INTO MODIFICATIONS TO THE ATP MOLECULE TUNING ITS AGONIST-TO-ANTAGONIST ACTIVITY AT THE P2X RECEPTORS	77
P.74THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF AR170, A POTENT AND SELECTIVE A3 RECEPTOR AGONIST, IN A RAT MODEL OF COLITIS	200
P.83NEW 4’-TETRAZOLYL ADENOSINE DERIVATIVES AS POTENTIAL AGENTS FOR WOUND HEALING	209
Vona A.	240
S1-03MOLECULAR MECHANISMS FOR A3 ADENOSINE RECEPTOR-MEDIATED PAIN CONTROL: AN IN VITRO STUDY ON DORSAL ROOT GANGLION NEURON EXCITABILITY	26
Vultaggio V.	240
P.60MITOCHONDRIA ARE A KEY TARGET OF AMYLOID β-DEPENDENT DAMAGE IN MOUSE MICROGLIAL CELLS: ROLE OF THE P2X7 RECEPTOR AND PROTECTION BY NIMODIPINE	186
P.85THE P2X7 RECEPTOR IS SHED INTO CIRCULATION AND CORRELATES WITH C-REACTIVE PROTEIN LEVELS	211
Wang L.	240
S17-01ATP RELEASE FROM MAST CELLS BY ACUPUNCTURE STIMULI	105
Wang Y.	240
S17-02THE ROLE OF PURINE RECEPTOR IN THE TREATMENT OF DEPRESSION BY taVNS	106
P.75P2X7R PLAY AN IMPORTANT ROLE IN ANTIDEPRESSANT EFFECT OF TAVNS	201
Wellbrock J.	240
P.68CHARACTIZATION OF CD39 EXPRESSION ON T CELLS IN ACUTE MYELOID LEUKEMIA	194
Weng T.	240
S7-01ADENOSINE AT THE CROSS-ROADS OF LUNG FIBROSIS AND PULMONARY HYPERTENSION	54
Wesslau K.	240
P.105P2X7R INDIRECTLY REGULATES THE JAM-A PROTEIN CONTENT VIA MODULATION OF THE GSK-3β AND PKC-β1	231
Weston P.	241
S7-04EXTRACELLULAR ATP REGULATES ANGIOGENIC RESPONSES IN VASA VASORUM ENDOTHELIAL CELLS VIA THE ACTIVATION OF PI3K-AKT-mTOR SIGNALING AXIS AND C-JUN, FOXO3A, AND C-MYC TRANSCRIPTION FACTORS	57
Wilder T.	241
P.100TENOFOVIR CAUSES BONE LOSS VIA DECREASED BONE FORMATION AND INCREASED BONE RESORPTION, WHICH CAN BE COUNTERACTED BY ADENOSINE A2A RECEPTOR IN MICE	226
Wildner N.	241
P.68CHARACTIZATION OF CD39 EXPRESSION ON T CELLS IN ACUTE MYELOID LEUKEMIA	194
Wiley J.	241
S19-03THE P2X7 RECEPTOR HAS A SCAVENGER ROLE IN THE CENTRAL NERVOUS SYSTEM WHICH IS LITTLE AFFECTED BY ANTAGONISTS OF P2X7 PORE FUNCTION	117
Winter K.	241
P.98RENAL PAPILLA EXPRESSES HIGH LEVELS OF THE UDP-GLUCOSE RECEPTOR P2RY14	224
Winzer R.	241
P.18T CELL-DERIVED EXOSOMAL CD73 MEDIATES IMMUNE SUPPRESSION	144
Wisztorski M.	241
P.63NEURONAL ADENOSINE A2A RECEPTOR OVEREXPRESSION EXACERBATES MEMORY DEFICITS IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE.	189
Wu Q.	241
S17-03PURINERGIC SIGNALING IN INFLAMMATORY BOWEL DISEASE AND IT’S ROLE IN THE EFFECT OF ACUPUNCTURE AND MOXIBUSTION	107
Wujak M.	241
S4-04EMERGING ROLE OF NUCLEOTIDE-METABOLIZING ENZYMES IN REGULATION OF MESENCHYMAL STEM CELLS FATE	43
Xapelli S.	241
S15-01ADENOSINE A2A RECEPTORS AND BDNF: AN INTIMATE INTERACTION REGULATING POSTNATAL HIPPOCAMPAL NEUROGENESIS	94
P.36ADENOSINERGIC SYSTEM: NOVEL THERAPEUTIC TARGET FOR RETT SYNDROME	162
P.103POSTNATAL SUBVENTRICULAR ZONE NEUROGENESIS: ADENOSINE A2A RECEPTORS AS REGULATORS OF BRAIN-DERIVED NEUROTROPHIC FACTOR	229
Xia Y.	241
S7-01ADENOSINE AT THE CROSS-ROADS OF LUNG FIBROSIS AND PULMONARY HYPERTENSION	54
Xu X.	241
S15-02CORTICAL NEURONAL MIGRATION ENTAILS A2A RECEPTOR-DRIVEN NEURONAL POLARIZATION AND AXON FORMATION	95
Yegutkin G.	241
S12-02EXTRA- AND INTRACELLULAR METABOLISM OF ADENOSINE IN CANCER AND INFLAMMATION	80
Yin Yan Hai	241
S17-04PURINERGIC SIGNALLING AND ACUPUNCTURE-INDUCED ANALGESIA	108
Ying Z.	241
S1-02THE ASIC3/P2X3 COGNATE RECEPTOR SENSES ACIDIC AND PURINERGIC PAIN IN A NOVEL MANNER	25
S17-04PURINERGIC SIGNALLING AND ACUPUNCTURE-INDUCED ANALGESIA	108
Yong Tang	241
S1-02THE ASIC3/P2X3 COGNATE RECEPTOR SENSES ACIDIC AND PURINERGIC PAIN IN A NOVEL MANNER	25
Simposium 17: ACUPUNCTURE AND PURINERGIC MECHANISM	104
S17-04PURINERGIC SIGNALLING AND ACUPUNCTURE-INDUCED ANALGESIA	108
Young M.	241
S11-03THE MOLECULAR DETERMINANTS OF SMALL-MOLECULE BINDING AT P2X RECEPTORS	76
P.03IDENTIFYING REGIONS OF P2X7 RECEPTOR INTRACELLULAR DOMAINS INVOLVED IN DOWNSTREAM SIGNALING	129
Zabala A.	241
S19-04P2X4 RECEPTOR CONTROLS MICROGLIA ACTIVATION AND FAVOURS REMYELINATION IN AUTOIMMUNE ENCEPHALITIS	118
Zahiri D.	241
P.84INTERACTION OF THE SPHINGOSINE-1-PHOSPHATE PATHWAY WITH PURINERGIC RECEPTORS	210
Zemkova H.	241
P.01IDENTIFICATION OF P2X7 RECEPTOR EXTRACELLULAR VESTIBULE RESIDUES CONTRIBUTING TO RECEPTOR STRUCTURE AND CHANNEL GATING	127
Zhang Y.	241
S17-04PURINERGIC SIGNALLING AND ACUPUNCTURE-INDUCED ANALGESIA	108
P.75P2X7R PLAY AN IMPORTANT ROLE IN ANTIDEPRESSANT EFFECT OF TAVNS	201
Zhao Y.	241
S17-04PURINERGIC SIGNALLING AND ACUPUNCTURE-INDUCED ANALGESIA	108
Zhou Z.	241
P.89THE ACTIVATION OF ADENOSINE A2A BUT NOT A2B RECEPTORS IS INVOLVED IN URIDINE ADENOSINE TETRAPHOSPHATE-MEDIATED CORONARY SMOOTH MUSCLE RELAXATION	215
Ziberi S.	241
S4-01INFLUENCE OF DIFFERENT PURINE RECEPTORS ON THE DIFFERENTIATION POTENTIAL OR MALIGNANCY OF NORMAL OR CANCEROUS MESENCHYMAL STEM CELLS, RESPECTIVELY	40
P.02P2X7 RECEPTOR ACTIVATION INCREASESMESENCHYMAL TRANSDIFFERENTIATION AND INVASIVENESS OF GLIOBLASTOMA-DERIVED STEM-LIKE CELLS	128
P.15P2X7 RECEPTOR MODULATES THE OSTEOGENIC DIFFERENTIATION OF STROMAL STEM CELLS FROM HUMAN ADIPOSE TISSUE	141
P.42INVESTIGATING THE ROLE OF GUANOSINE IN HUMAN NEUROBLASTOMA CELL DIFFERENTIATION.	168
Zimmermann H.	241
P.64THE ADP RECEPTOR P2Y13 IS SELECTIVELY EXPRESSED IN BRAIN MICROGLIA AND CONSTITUTIVELY ATTENUATES HIPPOCAMPAL NEUROGENESIS	190
Zinke J.	241
P.20P.A METABOLIC IMMUNE CHECKPOINT: ADENOSINE IN BRAIN METASTASES TUMOR MICROENVIRONMENT	146
Zipfel N.	241
S8-04STRUCTURE-FUNCTION RELATIONSHIP OF P2X7 RECEPTORS	62
Zoppas E.	241
P.80INVESTIGATION ON THE ROLE OF THE P2X7R-NLRP3-IL-1β AXIS IN THE PATHOGENESIS OF HIDRADENITIS SUPPURATIVA	206
Zuccarini M.	241
S4-01INFLUENCE OF DIFFERENT PURINE RECEPTORS ON THE DIFFERENTIATION POTENTIAL OR MALIGNANCY OF NORMAL OR CANCEROUS MESENCHYMAL STEM CELLS, RESPECTIVELY	40
S12-04CONFLICTING EFFECTS OF GUANOSINE, GUANINE AND THEIR METABOLIZING ENZYMES ON NEUROPROTECTION AND TUMOR CELL PROLIFERATION	82
P.02P2X7 RECEPTOR ACTIVATION INCREASESMESENCHYMAL TRANSDIFFERENTIATION AND INVASIVENESS OF GLIOBLASTOMA-DERIVED STEM-LIKE CELLS	128
P.15P2X7 RECEPTOR MODULATES THE OSTEOGENIC DIFFERENTIATION OF STROMAL STEM CELLS FROM HUMAN ADIPOSE TISSUE	141
P.42INVESTIGATING THE ROLE OF GUANOSINE IN HUMAN NEUROBLASTOMA CELL DIFFERENTIATION.	168

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