Anales RANF

Simposium 15: KEY ROLES OF ADENOSINE A2A RECEPTORS THROUGHOUT BRAIN DEVELOPMENT Chairs : Rodrigo A. Cunha (Coimbra, Portugal) / Sabine Levi (Paris, France) Content : Purinergic signaling mediated by ATP and adenosine plays an essential role in the nervous system where it mediates fast neurotransmission and neuromodulation. This symposium will highlight recent and important discoveries regarding the contribution of the adenosine signaling pathway in brain development. We have gathered four speakers who will present evidences that Adenosine A 2A receptors govern neurogenesis, neuronal migration, axon formation and outgrowth, maintenance of newly formed synapses, and microglia morphology and function. Alterations in adenosine signaling during the critical period of development may lead to epilepsy, cognitive deficits and adult mood disorders.