Anales RANF

S6-02 A NEW CONDITIONAL MODEL TO STUDY ADENOSINE A2AR DYSFUNCTION IN ALZHEIMER’S DISEASE D. Blum 1 Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc, LabEx DISTALZ, F-59000 Lille, France. Adenosine A 2A receptors (A 2A Rs) are abnormally upregulated in various neurological conditions, notably characterized by cognitive alterations. Beneficial impact of A 2A R blockade towards cognition and pathological impairments observed in such disorders support that the dysregulation of A 2A receptors is instrumental in their pathophysiological development. To address this question, we have developed new transgenic tools to conditionally overexpress A 2A Rs in mice for instance in neurons or astrocytes. In our laboratory, by combining to transgenic models reproducing amyloid and Tau lesions, these new models have been used to uncover the role of A 2A Rs in the development of Alzheimer’s Disease (AD). In the present contribution, we will describe our new genetic models and provide results linking A 2A receptor dysfunctions and synaptic impairments in animal models of AD. Fundings: Fondation pour la Recherche Médicale, Fondation Alzheimer, ANR, Inserm, Région Hauts de France, Université de Lille, Labex DISTALZ