Anales RANF

Simposium 6: NEW GENETIC TOOLS FOR UNDERSTANDING CELL-SPECIFIC PURINOCEPTOR FUNCTION IN HEALTH AND DISEASES Chairs : Annette Nicke (Munich, Germany) Content : Alterations of purinergic signals are associated with numerous disorders of cardiac and respiratory function, inflammation, chronic pain syndromes and various CNS diseases including neurodegenerative diseases associated with neuroinflammation. Adenosine and purinergic receptors are expressed in various peripheral cell types as well as in various neuronal and glial cells within CNS, it is thus crucial to decipher the cell-specific function of each receptor in pathological contexts. We will cover in this symposium very recent and ongoing validation of new transgenic animal models and molecular tools useful to better understand P2X and adenosine receptor functions.