Anales RANF

Simposium 3: PURINERGIC RECEPTORS AS FUTURE TARGETS IN ALZHEIMER’S DISEASE? Chairs : David Blum (Lille, France) / Annett Halle (Bonn, Germany) Content : Alzheimer’s Disease is a major health concern with no treatment available to significantly slow down or halt cognitive symptoms. Facing approaches which target neuropathological lesions and that have not proven efficiency yet, it is mandatory to develop alternative strategies. Purine homeostasis is disrupted in Alzheimer’s Disease involving immune and plasticity dysfunctions which favor the development of cognitive deficits. In the present symposium, speakers will give new insights into the role of purinergic signaling in thepathophysiological development of Alzheimer’s Disease and discuss the therapeutic perspectives.