Anales RANF

P.79 COLLABORATIVE RESEARCH CENTER SFB 1328: ADENINE NUCLEOTIDES IN IMMUNITY AND INFLAMMATION A. Guse 1 , C. Müller 2 , C. Meier 1 , C. Lohr 1 1 University of Hamburg, Hamburg, Germany; 2 University of Bonn, Bonn, Germany. Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling. Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown. The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti- inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation. Based on the local Research Network “Regulatory Adenine Nucleotides at Membranes” (Landesforschungsförderung Hamburg), the collaborative research center SFB 1328 has been formed, centrally located in Hamburg. National and international experts in the AN research field from Bonn, Genova (Italy), Göttingen und Munich significantly strengthen our initiative. By interdisciplinary integration we will develop an integral view of AN biology and pathophysiology, providing the basis for novel diagnostic methods and innovative treatment strategies, focusing on inflammatory diseases in immune, adipose and nervous systems. The poster will present the aims, structure and job opportunities of the SFB 1328. Funded by the Deutsche Forschungsgemeinschaft.