Anales RANF

Simposium 21: TEACHING CAFFEINE NEW TRICKS FOR OLD PROBLEMS IN PARKINSON'S DISEASE Chairs : Luisa Lopes (Lisboa, Portugal) / Jiang-Fan Chen (Boston, USA) Content : Caffeine and adenosine receptor ligands have been on trial against motor symptoms in Parkinson's disease with very little efficacy, albeit their demonstrated benefits in epidemiological studies in patients. This hints at a predominant early, non- motor effect of the caffeine analogs that has been poorly discussed. We will cover very recent research and state-of-the-art tools that are providing new clues for these non- motor aspects, namely the effects on protein aggregation and spreading, receptor dimerization and cognition. We hope to contribute to a timely discussion while highlighting novel mechanisms that could be of general interest and applications beyond PD, to the wider neuropurine audience. 1. Jiang-Fan Chen (Boston School of Medicine, Boston, USA) 2. Poul Jensen (Arrhus University, Arrhus, Denmark) 3. Joana Coelho (iMM, Lisboa, Portugal)