Anales RANF

Simposium 20: FIGHTING THE FIRE: NOVEL PURINERGIC APPROACHES TO MANAGE IMMUNE-MEDIATED DISORDERS Chairs : Luca Antonioli (Pisa, Italy) / Carmen Montesinos (Valencia, Spain) Content : Inflammation is a defense reaction aimed at eliminating the harmful agent from the organism and restoring tissue homeostasis. This process involves a series of immunological mechanisms able to modulate the activity of immune cells in order to preserve the integrity of our body. A number of studies revealed the critical role of the purine system (ATP and adenosine, mainly) in the modulation of inflammatory processes. Indeed, ischemia and hypoxic conditions at the inflammation site cause the release of high amounts of ATP, promoting the activation of the immune system through the interaction with purinergic receptors. The present symposium will provide novel evidences about the role of purines in the pathophysiology of the inflammatory process, highlighting its potential as a possible target for the development of innovative strategies useful for the pharmacological treatment of immune-inflammatory disorders.