Anales RANF

Simposium 19: IMPACT OF PURINERGIC SIGNALLING IN MULTIPLE SCLEROSIS PATHOLOGY Chairs : Carlos Matute (Leioa, Spain) / María Domercq (Leioa, Spain) Content : Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by massive infiltration of immune cells, demyelination, and axonal loss. However, spontaneous myelin repair can occur during the course of the disease. A major component of this regenerative process is a robust innate immune response consisting of infiltrating macrophages and brain microgliosis. Therefore, specifically targeting myeloid cells could be an attractive therapeutic approach. Purinergic receptors control not only immune cell function together with the activation of microglia and astrocytes, but also neuronal and oligodendroglial survival in the pathology. Our symposium will include four different speakers talking about the role in MS of purinergic receptors, mainly P2X7 and P2X4. Claudia Verderio will focus on how microvesicles released by microglia in response to ATP influence oligodendrocyte progenitor cell function during remyelination. Susana Mato will talk about the role of P2X7 receptor in oligodendrocytes and microglia during primary demyelination. James Wiley will describe the scavenger activity of P2X7 receptors and its impact in MS disease. Finally, Maria Domercq’s talk will be focused on the role of P2X4 modulating microglia/macrophage inflammatory responses and promoting the repair of myelin damage.